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Microfluidic emulation of mechanical circulatory support device shear-mediated platelet activation.
Abstract Thrombosis of ventricular assist devices (VADs) compromises their performance, with associated risks of systemic embolization, stroke, pump stop and possible death. Anti-thrombotic (AT) drugs, utilized to limit thrombosis, are largely dosed empirically, with limited testing of their efficacy. Further, such testing, if performed, typically examines efficacy under static conditions, which is not reflective of actual shear-mediated flow. Here we adopted our previously developed Device Thrombogenicity Emulation methodology to design microfluidic platforms able to emulate representative shear stress profiles o...
Source: Biomedical Microdevices - November 21, 2015 Category: Biomedical Engineering Authors: Dimasi A, Rasponi M, Sheriff J, Chiu WC, Bluestein D, Tran PL, Slepian MJ, Redaelli A Tags: Biomed Microdevices Source Type: research