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Improvement in Cognitive Function and Reducing the Risk of Developing Cardiovascular Events/ Stroke in Homocysteinemia
A patient presenting with recurrent stroke and angina was diagnosed with homocysteinemia. Elevated homocysteine levels increase the risk of atherosclerosis and venous thrombosis, which can lead to strokes, and cardiovascular events, while significantly impacting an individual's brain function, including the onset of depression/psychosis.
Source: Journal of Clinical Lipidology - July 1, 2023 Category: Lipidology Authors: Kirollos Gabrah, Mirra Srinivasan, Hadia Arzoun, Siji Thomas, Barry Tedder Tags: Genetic Disorders Source Type: research

Association between lipoprotein(a) and thromboembolism in patients with non-valvular atrial fibrillation: a cross-sectional study
Lipoprotein(a) [Lp(a)] is a recognized risk factor for ischemic stroke (IS); however, its role in thromboembolism in patients with non-valvular atrial fibrillation (NVAF) remains controversial. We aimed to ass...
Source: Lipids in Health and Disease - August 25, 2022 Category: Lipidology Authors: Jie Song, Xiaoxue Zhang, Meng Wei, Yakun Bo, Xianhui Zhou and Baopeng Tang Tags: Research Source Type: research

JCL Roundtable: Global Think Tank on Lipoprotein(a)
Lipoprotein(a) operates in causal pathways to promote atherosclerosis, arterial thrombosis, and aortic stenosis. It has been associated with rare cases of nonatherosclerotic arterial thrombotic stroke at any age. Inherited variation of lipoprotein(a) levels substantially increases cardiovascular risk in 20% of people worldwide. Recent progress in identifying the risk associated with lipoprotein(a) and in pursuing effective treatment has led to a recent Global Think Tank including representatives from the European Atherosclerosis Society, American Heart Association, Preventive Cardiovascular Nurses Association, National Lip...
Source: Journal of Clinical Lipidology - May 1, 2021 Category: Lipidology Authors: Lisa L. Maher, S. Lale Tokg özoğlu, Eduardo J. Sanchez, James A. Underberg, John R. Guyton Source Type: research

Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients
Specific clinical risk factors may contribute to improving or worsening neurological functions in acute ischemic stroke (AIS) patients pre-treated with a combined cholesterol reducer and recombinant tissue pla...
Source: Lipids in Health and Disease - May 6, 2020 Category: Lipidology Authors: Nicolas Poupore, Dan Strat, Tristan Mackey, Katherine Brown, Ashley Snell and Thomas I. Nathaniel Tags: Research Source Type: research

Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids
Publication date: November 2018Source: Prostaglandins & Other Lipid Mediators, Volume 139Author(s): Reheman Adili, Megan Hawley, Michael HolinstatAbstractThrombosis is the most common underlying pathology responsible for morbidity and mortality in cardiovascular disease (CVD). Platelet adhesion, activation, and aggregation play central roles in hemostasis; however, the same process may also cause thrombosis and vessel occlusion at the site of ruptured atherosclerotic lesions leading to heart attack and stroke. ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) are an essential component of the platelet phospholipid membrane...
Source: Prostaglandins and Other Lipid Mediators - October 4, 2018 Category: Lipidology Source Type: research

Optimized Extraction of 2‐Arachidonyl Glycerol and Anandamide from Aortic Tissue and Plasma for Quantification by LC‐MS/MS
In this study, we investigated several sample preparation options for the LC‐MS quantification of AEA and 2‐AG from plasma and aortic tissue. The extractions considered included liquid‐liquid (LLE), solid‐phase (SPE), and supported‐liquid (SLE). Some extraction protocols yielded high analyte recovery and prevention of 1‐AG/2‐AG isomerization. Our results indicate that a liquid‐liquid extraction using toluene yields the highest recovery for both analytes, coupled with low ionization suppression in the mass spectrometer. This extraction and corresponding LC‐MS/MS assay provides a simple, high throughput mec...
Source: European Journal of Lipid Science and Technology - June 23, 2015 Category: Lipidology Authors: Christopher Garst, Makenzie Fulmer, Doug Thewke, Stacy Brown Tags: Short Communication Source Type: research