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Periprocedural cerebrovascular complications and 30-day outcomes of endovascular treatment for intracranial vertebral artery dissecting aneurysms
CONCLUSIONS: Hyperlipidemia, IS history, and SAH were independent predictors for overall periprocedural cerebrovascular complications of endovascular treatment for IVADAs, but aneurysmal height was an independent protective factor. SAH and preprocedural mRS score > 2 were independent risk factors for perforator occlusion stroke. Preprocedural mRS score > 2 and periprocedural complications were independent risk factors for 30-day unfavorable clinical outcomes.PMID:36401540 | DOI:10.3171/2022.10.JNS221953
Source: Journal of Neurosurgery - November 19, 2022 Category: Neurosurgery Authors: Jiangli Han Fei Liu Jigang Chen Xin Tong Mingyang Han Fei Peng Hao Niu Lang Liu Aihua Liu Source Type: research

Intra-arterial injection of mesenchymal stem cells to accelerate neointima formation after endovascular stenting in a rabbit model
CONCLUSIONS: The intra-arterial injection of MSCs after endovascular stenting accelerated early neointima formation but had no effect on thrombus formation in this study. Larger studies are required to verify these findings and determine the durability and mechanism of this effect.PMID:35090127 | DOI:10.3171/2021.11.JNS212372
Source: Journal of Neurosurgery - January 28, 2022 Category: Neurosurgery Authors: Kapilan Panchendrabose Sandeep Muram Brooke L Belanger Muneer Eesa Mohammed A Almekhlafi Mayank Goyal John H Wong Arindom Sen Bijoy K Menon Bryan Har Alim P Mitha Source Type: research

Mechanical thrombectomy and intravascular imaging for cerebral venous sinus thrombosis: a preclinical model.
CONCLUSIONS: The authors describe a preclinical model to assess endovascular techniques and devices for the treatment of CVST. Repurposed devices from arterial stroke may not perform as expected, given the unique features of venous sinus thrombosis. Residual bridging cortical vein thrombus and residual sinus thrombus, visualized on intravascular OCT, may be present despite complete sinus recanalization on angiography, and this may be the etiology of the poor clinical outcome despite technical success. In the setting of bridging cortical vein thrombus after successful sinus thrombectomy, direct chemical thrombolysis may be ...
Source: Journal of Neurosurgery - October 30, 2020 Category: Neurosurgery Authors: Pasarikovski CR, Ku JC, Keith J, Ramjist J, Dobashi Y, Priola SM, da Costa L, Kumar A, Yang VXD Tags: J Neurosurg Source Type: research

Analysis of human emboli and thrombectomy forces in large-vessel occlusion stroke.
CONCLUSIONS: Current thrombectomy devices remove emboli mostly by applying linear tensile forces, under which emboli elongate until dissociation. Embolus resistance to dissociation is determined by embolus strength, which significantly correlates with composition and varies within and among patients and within the same thrombus. The dynamic intravascular weakening of emboli during removal may lead to iatrogenic embolization. PMID: 32109875 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 27, 2020 Category: Neurosurgery Authors: Liu Y, Zheng Y, Reddy AS, Gebrezgiabhier D, Davis E, Cockrum J, Gemmete JJ, Chaudhary N, Griauzde JM, Pandey AS, Shih AJ, Savastano LE Tags: J Neurosurg Source Type: research

Outcomes after coverage of lenticulostriate vessels by flow diverters: a multicenter experience.
CONCLUSIONSThe use and versatility of flow diversion is increasing, and safety data are continuing to accumulate. Here, the authors provide early data on the safety of covering lenticulostriate vessels with flow diverters. The authors concluded that the coverage of these perforators does not routinely lead to clinically significant ischemia when dual antiplatelet therapy is continued for 6 months. Further evaluation is needed in larger cohorts and with imaging follow-up as experience develops in using these devices in more distal circulation. PMID: 30641842 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 11, 2019 Category: Neurosurgery Authors: Wagner KM, Srinivasan VM, Srivatsan A, Ghali MGZ, Thomas AJ, Enriquez-Marulanda A, Alturki AY, Ogilvy CS, Mokin M, Kuhn AL, Puri A, Grandhi R, Chen S, Johnson J, Kan P Tags: J Neurosurg Source Type: research

Combined interventional and surgical treatment of tandem middle cerebral artery embolus and internal carotid artery occlusion: case report.
Abstract Tandem internal carotid artery (ICA) origin occlusion and middle cerebral artery (MCA) thromboembolism is a life-threatening condition with poor neurological outcome. The authors report on a patient presenting with acute ischemic stroke from a tandem ICA and MCA occlusion with penumbra. Emergency MCA mechanical thrombectomy was performed through percutaneous cervical ICA access due to the inability to cross the cervical carotid occlusion. Emergency carotid endarterectomy to reperfuse the poorly collateralized hemisphere and repair the ICA access site was performed 2 hours after completion of tissue plasmi...
Source: Journal of Neurosurgery - November 17, 2017 Category: Neurosurgery Authors: Frenkel MB, Renfrow JJ, Singh J, Garg N, Wolfe SQ Tags: J Neurosurg Source Type: research

Body habitus, serum albumin, and the outcomes after craniotomy for tumor: a National Surgical Quality Improvement Program analysis.
CONCLUSIONS In this National Surgical Quality Improvement Program analysis evaluating patients who underwent craniotomy for tumor, body habitus was not associated with differential mortality or neurological complications. However, obese patients had increased odds of a major perioperative complication, primarily due to higher rates of venous thromboembolic events and surgical site infections. Preoperative hypoalbuminemia was associated with increased odds of mortality and a nonroutine hospital discharge, suggesting that serum albumin may have utility in stratifying risk preoperatively in patients undergoing craniotomy. ...
Source: Journal of Neurosurgery - May 19, 2016 Category: Neurosurgery Authors: Dasenbrock HH, Liu KX, Chavakula V, Devine CA, Gormley WB, Claus EB, Smith TR, Dunn IF Tags: J Neurosurg Source Type: research

Submaximal angioplasty for symptomatic intracranial atherosclerosis: a prospective Phase I study.
CONCLUSIONS This study demonstrates the safety of the submaximal angioplasty technique, with no permanent periprocedural complications in 24 treated patients. PMID: 26745485 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 8, 2016 Category: Neurosurgery Authors: Dumont TM, Sonig A, Mokin M, Eller JL, Sorkin GC, Snyder KV, Nelson Hopkins L, Levy EI, Siddiqui AH Tags: J Neurosurg Source Type: research

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