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Condition: Thrombosis
Management: WHO

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Total 37 results found since Jan 2013.

Signal for Thrombosis with Eltrombopag and Romiplostim: A Disproportionality Analysis of Spontaneous Reports Within VigiBase ®
Conclusion This study suggests the presence of a signal for an increased risk of thrombosis with eltrombopag compared with romiplostim. These results must be confirmed and quantified by large aetiological pharmacoepidemiological studies.
Source: Drug Safety - September 4, 2015 Category: Drugs & Pharmacology Source Type: research

HRT increases ovarian cancer risk by small amount
Conclusion This systematic review and meta-analysis showed that ovarian cancer risk was significantly increased in current HRT users, even in those with less than five years of HRT use (the average was three years). In ex-users, risks decreased the longer ago HRT use had stopped, but risks during the first few years after stopping remained significant. Furthermore, about a decade after stopping, long-duration hormone therapy use (average nine years of HRT use), there still seemed to be a small excess risk. The review has a few limitations, however. The main one is that the review was heavily influenced by just two of t...
Source: NHS News Feed - February 13, 2015 Category: Consumer Health News Tags: Cancer Medication Older people Source Type: news

Stroke in Children with Human Immunodeficiency Virus in Botswana: A Report of Six Cases (P4.303)
CONCLUSIONS: The risk of stroke appears to be increased in children with HIV, though further controlled studies are necessary to further investigate this. Etiologies for stroke in children with HIV includes HIV vasculopathy, HIV cardiomyopathy, and opportunistic infections. Evaluation should include head imaging with vascular imaging, MRI with MRA if possible, and CT. The utility of lumbar puncture and hypercoaguability workup in this population needs to be investigated further. Given the difficulties of monitoring anticoagulation in this setting, low dose aspirin is a reasonable first line treatment.Disclosure: Dr. Khuran...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khurana, E., Bearden, D. Tags: NeuroAIDS Source Type: research

Targeting Platelet G Protein‐Coupled Receptors for Antithrombotic Therapy
Abstract Platelets are small anucleated cells produced by bone marrow megakaryocytes that circulate in the blood as sentinels of vascular integrity. They play a pivotal role in the regulation of vascular homeostasis through adhesion to the injured vessel wall, aggregation, propagation of coagulation, and thrombus formation. Furthermore, platelets are also involved in fibrinolysis and the repair of the blood vessel wall, restoring blood flow and vascular integrity. Under pathophysiological conditions such as atherosclerosis, inappropriate platelet aggregation and clot formation can cause vascular occlusions, resultin...
Source: Drug Development Research - October 21, 2013 Category: Drugs & Pharmacology Authors: Knut Fälker, Marc Nazare, Peter Wonerow, Detlef H. Kozian Tags: Research Overview Source Type: research

Reply
We appreciate the interest that Drs Aznar and Cerdá have expressed in our Clinical Opinion piece. We did not intend to minimize the importance of factor V Leiden as a risk factor for venous thromboembolism (VTE) in women taking combined oral contraceptives (COCs). However, we primarily addressed the risks of myocardial infarction (MI) and ischemic stroke (IS), which are arterial thrombotic events, with COCs. Accordingly, we cited some well-established risk factors for MI and IS, and we suggested that tools such as the Framingham risk calculator may be helpful adjuncts to American College of Obstetricians and Gynecologists...
Source: American Journal of Obstetrics and Gynecology - March 1, 2013 Category: OBGYN Authors: Christopher R. McCartney, Jennifer P. Beller Tags: Letters to the Editors Source Type: research

Determinants of early case‐fatality among stroke patients in Maputo, Mozambique and impact of in‐hospital complications
The burden of stroke is increasing in developing countries that struggle to manage it efficiently. We identified determinants of early case‐fatality among stroke patients in Maputo, Mozambique, to assess the impact of in‐hospital complications. Patients admitted to any hospital in Maputo with a new stroke event were prospectively registered (n = 651) according to the World Health Organization's STEPwise approach, in 2005–2006. We assessed the determinants of in‐hospital and 28‐day fatality, independently of age, gender and education, and computed population attributable fractions. In‐hospital mortality was ...
Source: International Journal of Stroke - January 1, 2013 Category: Neurology Authors: Joana Gomes, Albertino Damasceno, Carla Carrilho, Vitória Lobo, Hélder Lopes, Tavares Madede, Pius Pravinrai, Carla Silva‐Matos, Domingos Diogo, Ana Azevedo, Nuno Lunet Tags: Panorama Source Type: research

Functional Recovery at 3 Months in Stroke Patients Not Receiving Thrombolytic Therapy: The Comparison Between Patients Arriving Earlier and Later Than 4.5 Hours
Conclusion: Stroke patients arriving at the hospital within and after 4.5 hours of the onset who did not receive the rtPA did not have significant differences in the functional outcomes and quality of life at 3 months. However, the eligibility for rtPA is not known before arriving at the hospital so that the necessity of seeking medical treatment as quickly as possible is still warranted. Increasing effective public awareness regarding stroke risk factors and care should be implemented.
Source: Journal of Stroke and Cerebrovascular Diseases - November 30, 2012 Category: Neurology Authors: Sujittra Duangjit, Weerasak Muangpaisan, Wattanachai Chotinaiwattarakul, Pornpatr Dharmasaroja Tags: Original Articles Source Type: research