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Cerebrovascular Complications of COVID-19 and COVID-19 Vaccination
Circ Res. 2022 Apr 15;130(8):1187-1203. doi: 10.1161/CIRCRESAHA.122.319954. Epub 2022 Apr 14.ABSTRACTThe risk of stroke and cerebrovascular disease complicating infection with SARS-CoV-2 has been extensively reported since the onset of the pandemic. The striking efforts of many scientists in cooperation with regulators and governments worldwide have rapidly brought the development of a large landscape of vaccines against SARS-CoV-2. The novel DNA and mRNA vaccines have offered great flexibility in terms of antigen production and led to an unprecedented rapidity in effective and safe vaccine production. However, as mass vac...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Manuela De Michele Joshua Kahan Irene Berto Oscar G Schiavo Marta Iacobucci Danilo Toni Alexander E Merkler Source Type: research

The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
Abstract The recent emergence of SARS-CoV-2 and the ensuing global pandemic has presented a health emergency of unprecedented magnitude. Recent clinical data has highlighted that COVID-19 is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease and stroke. Importantly, thrombotic complications are markers of severe COVID-19 and are associated with multi-organ failure and increased mortality. The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 is due to the ability of SARS-CoV-2 to invade endo¬...
Source: Circulation Research - June 25, 2020 Category: Cardiology Authors: McFadyen JD, Stevens H, Peter K Tags: Circ Res Source Type: research