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Source: Circulation Research
Condition: Thrombosis

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Total 26 results found since Jan 2013.

A Critical Role for ERO1 α in Arterial Thrombosis and Ischemic Stroke
CONCLUSIONS: Our results suggest that ERO1α acts as a thiol oxidase for Ca2+ signaling molecules, STIM1 and SERCA2, and enhances cytosolic Ca2+ levels, promoting platelet activation and aggregation. Our study provides evidence that ERO1α may be a potential target to reduce thrombotic events.PMID:37132383 | DOI:10.1161/CIRCRESAHA.122.322473
Source: Circulation Research - May 3, 2023 Category: Cardiology Authors: Vishwanath Jha Bei Xiong Tripti Kumari Gavriel Brown Jinzhi Wang Kyungho Kim Jingu Lee Nathan Asquith John Gallagher Lillian Asherman Taylor Lambert Yanyan Bai Xiaoping Du Jeong-Ki Min Rajan Sah Ali Javaheri Babak Razani Jin-Moo Lee Joseph E Italiano Jaeh Source Type: research

Platelets at the Vessel Wall in Non-Thrombotic Disease
Circ Res. 2023 Mar 17;132(6):775-790. doi: 10.1161/CIRCRESAHA.122.321566. Epub 2023 Mar 16.ABSTRACTPlatelets are small, anucleate entities that bud from megakaryocytes in the bone marrow. Among circulating cells, platelets are the most abundant cell, traditionally involved in regulating the balance between thrombosis (the terminal event of platelet activation) and hemostasis (a protective response to tissue injury). Although platelets lack the precise cellular control offered by nucleate cells, they are in fact very dynamic cells, enriched in preformed RNA that allows them the capability of de novo protein synthesis which ...
Source: Circulation Research - March 17, 2023 Category: Cardiology Authors: Anu Aggarwal Courtney L Jennings Emily Manning Scott J Cameron Source Type: research

Advances in Acute Ischemic Stroke Therapy
Circ Res. 2022 Apr 15;130(8):1230-1251. doi: 10.1161/CIRCRESAHA.121.319948. Epub 2022 Apr 14.ABSTRACTThe treatment of acute ischemic stroke continues to advance. The mainstay of treatment remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later treatment with alteplase is beneficial in patients selected with advanced imaging techniques. Tenecteplase has been evaluated as an alternative thrombolytic drug and evidence suggests that it is as least as effective as alteplase and may lyse large vessel clots more effectively. Endovascular therapy with mechanical thrombectomy has now been shown to be...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Yunyun Xiong Ajay K Wakhloo Marc Fisher Source Type: research

Cerebrovascular Complications of COVID-19 and COVID-19 Vaccination
Circ Res. 2022 Apr 15;130(8):1187-1203. doi: 10.1161/CIRCRESAHA.122.319954. Epub 2022 Apr 14.ABSTRACTThe risk of stroke and cerebrovascular disease complicating infection with SARS-CoV-2 has been extensively reported since the onset of the pandemic. The striking efforts of many scientists in cooperation with regulators and governments worldwide have rapidly brought the development of a large landscape of vaccines against SARS-CoV-2. The novel DNA and mRNA vaccines have offered great flexibility in terms of antigen production and led to an unprecedented rapidity in effective and safe vaccine production. However, as mass vac...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Manuela De Michele Joshua Kahan Irene Berto Oscar G Schiavo Marta Iacobucci Danilo Toni Alexander E Merkler Source Type: research

Epidemiology of Peripheral Artery Disease and Polyvascular Disease
Circ Res. 2021 Jun 11;128(12):1818-1832. doi: 10.1161/CIRCRESAHA.121.318535. Epub 2021 Jun 10.ABSTRACTAtherosclerotic lower extremity peripheral artery disease (PAD) is increasingly recognized as an important cause of cardiovascular morbidity and mortality that affects >230 million people worldwide. Traditional cardiovascular risk factors, including advanced age, smoking, and diabetes, are strongly linked to an increase risk of PAD. Although PAD has been historically underappreciated compared with coronary artery disease and stroke, greater attention on PAD in recent years has led to important new epidemiological insigh...
Source: Circulation Research - June 10, 2021 Category: Cardiology Authors: Aaron W Aday Kunihiro Matsushita Source Type: research

tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke.
Conclusions: Our findings suggest that immune invasion of the neurovascular unit represents a previously unrecognized mechanism underlying tPA-mediated brain hemorrhage, which can be overcome by precise immune modulation during thrombolytic therapy. PMID: 33070717 [PubMed - as supplied by publisher]
Source: Circulation Research - October 19, 2020 Category: Cardiology Authors: Shi K, Zou M, Jia DM, Shi S, Yang X, Liu Q, Dong J, Sheth KN, Wang X, Shi FD Tags: Circ Res Source Type: research

The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
Abstract The recent emergence of SARS-CoV-2 and the ensuing global pandemic has presented a health emergency of unprecedented magnitude. Recent clinical data has highlighted that COVID-19 is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease and stroke. Importantly, thrombotic complications are markers of severe COVID-19 and are associated with multi-organ failure and increased mortality. The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 is due to the ability of SARS-CoV-2 to invade endo¬...
Source: Circulation Research - June 25, 2020 Category: Cardiology Authors: McFadyen JD, Stevens H, Peter K Tags: Circ Res Source Type: research

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