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Cerebral edema in acute stroke: Effect of thrombolytic treatment
Cerebral edema (CED) is a common complication of ischemic stroke in Intensive Care Unit. Although frequently observed in patients undergoing intravenous thrombolytic (IVT) treatment, the pathogenic role of recombinant tissue plasminogen activator (rtPA) in CED induction has not yet been definitively clarified. The aim of our study is to verify the relationship between CED and rtPA in patients affected by acute ischemic stroke, without reperfusion signs, evaluating the CED growth rate in the first week after stroke onset.
Source: Journal of the Neurological Sciences - February 22, 2022 Category: Neurology Authors: Giovanni Frisullo, Simone Bellavia, Irene Scala, Pierandrea Rizzo, Aldobrando Broccolini, Valerio Brunetti, Maria Pepe, Fabio Pilato, Roberta Morosetti, Giacomo Della Marca, Paolo Calabresi Source Type: research

Clot evaluation and distal embolization risk during mechanical thrombectomy in anterior circulation stroke
Clot features along with patients' clinical features may influence thrombus compactness predisposing at distal embolization during thrombectomy. The aim of this study was to evaluate thrombus features assessed by radiological and histopathological analysis along with patient-related features to predict distal embolization during thrombectomy.
Source: Journal of the Neurological Sciences - December 13, 2021 Category: Neurology Authors: Fabio Pilato, Iacopo Valente, Rosalinda Calandrelli, Andrea Alexandre, Vincenzo Arena, Marco Dell'Aquila, Aldobrando Broccolini, Giacomo Della Marca, Roberta Morosetti, Giovanni Frisullo, Valerio Brunetti, Marisa Distefano, Alessandro Pedicelli, Cesare Co Source Type: research

Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series
We present a series of CVST cases with SARS-CoV-2 infection.Methods In a multinational retrospective study, we collected all cases of CVST in SARS-CoV-2 infected patients admitted to nine tertiary stroke centers from the beginning of the pandemic to June 30th, 2020. We compared the demographics, clinical and radiological characteristics, risk factors, and outcome of these patients with a control group of non-SARS-CoV-2 infected CVST patients in the same seasonal period of the years 2012 –2016 from the country where the majority of cases were recruited.
Source: Journal of the Neurological Sciences - October 14, 2020 Category: Neurology Authors: Ashkan Mowla, Banafsheh Shakibajahromi, Shima Shahjouei, Afshin Borhani-Haghighi, Nasrin Rahimian, Humain Baharvahdat, Soheil Naderi, Fariborz Khorvash, Davar Altafi, Seyed Amir Ebrahimzadeh, Ghasem Farahmand, Alaleh Vaghefi Far, Vijay K. Sharma, Saeideh Source Type: research

Atrial fibrillation, not atrial cardiopathy, is associated with stroke: A single center retrospective study
Atrial fibrillation (AF) increases the risk of thromboembolism. Atrial cardiopathy, defined as structural left atrial enlargement (LAE), has been proposed to be a unifying risk factor for stroke, with or without atrial fibrillation (AF). We sought to understand the relative importance of LAE and AF as risk factors for stroke.
Source: Journal of the Neurological Sciences - May 14, 2019 Category: Neurology Authors: Muhammad Affan, Abhimanyu Mahajan, Sumul Modi, Lonni Schultz, Angelos Katramados, Stephan A. Mayer, Daniel Miller Source Type: research

Low-dose versus standard-dose intravenous alteplase for octogenerian acute ischemic stroke patients: A multicenter prospective cohort study
The optimal dose of alteplase for acute ischemic stroke among geriatric patients is unclear. We aimed to assess the efficacy and safety of a low-dose (0.6  mg/kg) and standard-dose (0.9 mg/kg) alteplase for varying severity of Asian geriatric stroke patients.
Source: Journal of the Neurological Sciences - January 29, 2019 Category: Neurology Authors: A-Ching Chao, Ke Han, Sheng-Feng Lin, Ruey-Tay Lin, Chih-Hung Chen, Lung Chan, Huey-Juan Lin, Yu Sun, Yung-Yang Lin, Po-Lin Chen, Shinn-Kuang Lin, Cheng-Yu Wei, Yu-Te Lin, Jiunn-Tay Lee, Han-Hwa Hu, Chyi-Huey Bai, On behalf of the Taiwan Thrombolytic Ther Source Type: research

Hyperglycemia predicts unfavorable outcomes in acute ischemic stroke patients treated with intravenous thrombolysis among a Chinese population: A prospective cohort study
In this study, we investigated whether an elevated admission serum glucose level in the 3-h time window of intravenous thrombolysis for acute ischemic stroke determined poor functional outcomes among Chinese population.
Source: Journal of the Neurological Sciences - March 16, 2018 Category: Neurology Authors: Sheng-Feng Lin, A-Ching Chao, Han-Hwa Hu, Ruey-Tay Lin, Chih-Hung Chen, Lung Chan, Huey-Juan Lin, Yu Sun, Yung-Yang Lin, Po-Lin Chen, Shinn-Kuang Lin, Ming-Hui Sun, Cheng-Yu Wei, Yu-Te Lin, Jiunn-Tay Lee, Chi-Huey Bai, Taiwan Thrombolytic Therapy for Acut Source Type: research

Outcomes after acute ischemic stroke in patients with thrombocytopenia or thrombocytosis
Thrombocytopenia may be associated with a greater risk of cerebral hemorrhage and thrombocytosis may be associated with a greater risk of cerebral thrombosis. There is a paucity of studies focused on the potential association between blood platelet count (BPC) and outcomes after acute ischemic stroke (AIS). We hypothesized that abnormal BPC is associated with poorer outcomes after AIS.
Source: Journal of the Neurological Sciences - January 23, 2016 Category: Neurology Authors: Julio C. Furlan, Jiming Fang, Frank L. Silver Source Type: research

A novel embolic middle cerebral artery occlusion model induced by thrombus formed in common carotid artery in rat
Stroke is a major cause of death and disability in the worldwide. However, treatment options to date are very limited. To meet the need for validating the novel therapeutic approaches and understanding the physiopathology of the ischemic brain injury, experimental stroke models were critical for preclinical research. However, commonly used embolic stroke models are reluctant to mimic the clinical situation and not suitable for thrombolytic timing studies. In this paper, we established a standard method for producing a rat embolic stroke model with autologous thrombus formed within common carotid artery (CCA) by constant galvanic stimulation.
Source: Journal of the Neurological Sciences - October 2, 2015 Category: Neurology Authors: Yin-Zhong Ma, Li Li, Jun-Ke Song, Zi-Ran Niu, Hai-Feng Liu, Xiang-Shan Zhou, Fu-Sheng Xie, Guan-Hua Du Source Type: research

Post-thrombolysis haemostasis changes after rt-PA treatment in acute cerebral infarct. Correlations with cardioembolic etiology and outcome
: Little is known, in man, in the post-thrombolytic molecular dynamics of haemostasis, particularly the effect of rt-PA on antifibrinolytic components such as alpha2 anti-plasmin and Factor XIII. Aims and hypothesis: The purpose of this study was to systematically determine changes in coagulation and fibrinolytic parameters after thrombolysis with rt-PA during 24hours. We also aimed to correlate these parameters with different acute ischemic stroke subtypes and global outcome. Methods: Eighty consecutive patients with cerebral infarcts treated with rt-PA had their plasma levels of fibrinogen, plasminogen, alpha2-antiplasmi...
Source: Journal of the Neurological Sciences - December 29, 2014 Category: Neurology Authors: Xuhong Sun, Julien Berthiller, Laurent Derex, Paul Trouillas, Laho Diallo, Michel Hanss Source Type: research

The ratio of d-dimer to brain natriuretic peptide may help to differentiate between cerebral infarction with and without acute aortic dissection
Conclusion: We found that the d-dimer:BNP ratio may be helpful in distinguishing between cerebral infarction with and without AAD.Highlights:
Source: Journal of the Neurological Sciences - March 20, 2014 Category: Neurology Authors: Toshiyuki Okazaki, Yoko Yamamoto, Keishi Yoda, Shinji Nagahiro Tags: Original Articles Source Type: research

Reservations against new oral anticoagulants after stroke and cerebral bleeding
Abstract: Dabigatran, rivaroxaban, and apixaban are the new oral anticoagulants (NOAC) which have been investigated in patients with atrial fibrillation (AF) for primary and secondary prevention of stroke and thromboembolism. In these trials NOAC had a similar efficacy and safety profile compared to traditional vitamin-K-antagonists such as warfarin. We advise caution in the use of NOAC in patients with stroke or cerebral hemorrhage because of the following reasons:1) Patients with cerebral bleeding were excluded from the trials. 2) Stroke within 14days and severe stroke within 6months before screening were exclusion crite...
Source: Journal of the Neurological Sciences - April 29, 2013 Category: Neurology Authors: Claudia Stöllberger, Josef Finsterer Tags: Opinion Source Type: research

Experience of pediatric stroke from a tertiary medical center in North India
Conclusion: AIS is more common than ICH in this study and 8.9% patients died. Infection is the most common cause of pediatric stroke in Northern India which is amenable to therapy and is preventable.
Source: Journal of the Neurological Sciences - December 26, 2012 Category: Neurology Authors: Jayantee Kalita, Gourav Goyal, Usha Kant Misra Tags: Original Articles Source Type: research