Filtered By:
Source: Seminars in Thrombosis and Hemostasis
Condition: Thrombosis
This page shows you your search results in order of date.
Order by Relevance | Date
Total 49 results found since Jan 2013.
Ischemic Stroke in Cancer: Mechanisms, Biomarkers, and Implications for Treatment
Semin Thromb Hemost DOI: 10.1055/s-0043-1771270Ischemic stroke is an important cause of morbidity and mortality in cancer patients. The underlying mechanisms linking cancer and stroke are not completely understood. Long-standing and more recent evidence suggests that cancer-associated prothrombotic states, along with treatment-related vascular toxicity, such as with chemotherapy and immunotherapy, contribute to an increased risk of ischemic stroke in cancer patients. Novel biomarkers, including coagulation, platelet and endothelial markers, cell-free DNA, and extracellular vesicles are being investigated for their potentia...
Source: Seminars in Thrombosis and Hemostasis - July 28, 2023 Category: Hematology Authors: Costamagna, Gianluca Navi, Babak B. Beyeler, Morin Hottinger, Andreas F. Alberio, Lorenzo Michel, Patrik Tags: Review Article Source Type: research
Prevention of Venous Thromboembolism in Medical Patients with Thrombocytopenia or with Platelet Dysfunction: The Last 10 Years
Semin Thromb Hemost DOI: 10.1055/s-0043-1769013Current guideline recommendations for primary prophylaxis of venous thromboembolism (VTE) are based on randomized clinical trials that usually exclude subjects at a potentially high risk of bleeding complications. For this reason, no specific guideline is available for thromboprophylaxis in hospitalized patients with thrombocytopenia and/or platelet dysfunction. However, except in patients with absolute contraindications to anticoagulant drugs, antithrombotic prophylaxis should always be considered, for example, in hospitalized cancer patients with thrombocytopenia, especially...
Source: Seminars in Thrombosis and Hemostasis - May 18, 2023 Category: Hematology Authors: Tufano, Antonella Brenner, Benjamin Tags: Review Article Source Type: research
The Role of CD36/GPIV in Platelet Biology
Semin Thromb Hemost DOI: 10.1055/s-0043-1768935CD36 (also known as platelet glycoprotein IV) is expressed by a variety of different cell entities, where it possesses functions as a signaling receptor, but additionally acts as a transporter for long-chain fatty acids. This dual function of CD36 has been investigated for its relevance in immune and nonimmune cells. Although CD36 was first identified on platelets, the understanding of the role of CD36 in platelet biology remained scarce for decades. In the past few years, several discoveries have shed a new light on the CD36 signaling activity in platelets. Notably, CD36 has ...
Source: Seminars in Thrombosis and Hemostasis - May 16, 2023 Category: Hematology Authors: Bendas, Gerd Schlesinger, Martin Tags: Review Article Source Type: research
Viscoelastic Testing in the Clinical Management of Subarachnoid Hemorrhage and Intracerebral Hemorrhage
In conclusion, viscoelastic testing suggests hypercoagulation following SAH and ICH. Further investigation of the predictive value of increased clot firmness in SAH seems relevant. In ICH, the prediction of hematoma expansion and ICH as a complication to thrombolysis might be clinically relevant. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Seminars in Thrombosis and Hemostasis - September 13, 2022 Category: Hematology Authors: Hvas, Christine Lodberg Hvas, Anne-Mette Tags: Review Article Source Type: research
The Applicability of Thromboelastography in Acute Ischemic Stroke: A Literature Review
This article aims to highlight the potential use of TEG in AIS patients by reviewing available studies. We conducted a literature review, including PubMed and Cochrane library databases. The following keywords were used to find relevant studies: thromboelastography, TEG, acute ischemic stroke, stroke, coagulopathy, antiplatelet, and anticoagulant treatment. We identified 142 papers and after abstract review, we included 24 studies in this report. TEG identified a hypercoagulable state in AIS patients represented by short R, K, and greater α angle in all papers included. Modification of TEG parameters induced by intravenou...
Source: Seminars in Thrombosis and Hemostasis - September 5, 2022 Category: Hematology Authors: P îrlog, Bianca O. Grotta, James C. Tags: Review Article Source Type: research
Arterial Thrombotic Events in Hospitalized COVID-19 Patients: A Short Review and Meta-Analysis
In conclusion, we found a non-negligible proportion of ATE in patients hospitalized for COVID-19. Our results are similar to those found in hospitalized patients with influenza or with non-COVID viral pneumonia. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Seminars in Thrombosis and Hemostasis - July 6, 2022 Category: Hematology Authors: Candeloro, Matteo Schulman, Sam Tags: Review Article Source Type: research
Risk Factors for Major Adverse Cardiovascular Events and Major Adverse Limb Events after Venous Thromboembolism: A Large Prospective Cohort Study
Conclusions Risk factors for MACE and MALE after VTE included some traditional cardiovascular risk factors, patient's comorbidities, and some characteristics of VTE. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Seminars in Thrombosis and Hemostasis - June 30, 2022 Category: Hematology Authors: Noumegni, Steve Raoul Didier, Romain Mansourati, Vincent Moigne, Emmanuelle Le Mao, Raphael Le Hoffmann, Cl ément Moreuil, Claire De Tromeur, C écile Roux, Pierre-Yves Le Nasr, Bahaa Gentric, Jean-Christophe Guegan, Marie Poulhazan, Elise Lacut, Karine Tags: Review Article Source Type: research
Cerebral Venous Thrombosis
Semin Thromb Hemost DOI: 10.1055/s-0042-1742738Cerebral venous thrombosis (CVT) is a rare form of stroke that often affects younger age groups, especially reproductive age group females. CVT is a potentially fatal neurological condition that can be frequently overlooked due to the vague nature of its clinical and radiological presentation. Headache is the most common presenting symptom. However, a wide range of symptoms can be present and the symptom onset can be acute, subacute, or chronic. Neuroimaging is mandatory in cases where CVT is suspected. Both magnetic resonance venography and computed tomography venography can ...
Source: Seminars in Thrombosis and Hemostasis - February 15, 2022 Category: Hematology Authors: Aamodt, Anne Hege Skatt ør, Thor Håkon Tags: Review Article Source Type: research
Neurocoagulation from a Mechanistic Point of View in the Central Nervous System
Semin Thromb Hemost DOI: 10.1055/s-0041-1741569Coagulation mechanisms are critical for maintaining homeostasis in the central nervous system (CNS). Thrombin, an important player of the coagulation cascade, activates protease activator receptors (PARs), members of the G-protein coupled receptor family. PAR1 is located on neurons and glia. Following thrombin activation, PAR1 signals through the extracellular signal-regulated kinase pathway, causing alterations in neuronal glutamate release and astrocytic morphological changes. Similarly, the anticoagulation factor activated protein C (aPC) can cleave PAR1, following interact...
Source: Seminars in Thrombosis and Hemostasis - January 20, 2022 Category: Hematology Authors: Shavit-Stein, Efrat Berkowitz, Shani Gofrit, Shany Guly Altman, Keren Weinberg, Nitai Maggio, Nicola Tags: Review Article Source Type: research
Safety and Efficacy of Rivaroxaban for Inferior Vena Cava Thrombosis after Successful Catheter-Directed Thrombolysis
This study aimed at investigating the safety and efficacy of rivaroxaban for IVC thrombosis after CDT. The clinical data on 38 consecutive patients with IVC thrombosis (68% male; mean age, 51.5 ± 16.5), who received rivaroxaban after CDT between July 2017 and January 2020, were retrospectively analyzed in this study. Safety and efficacy of rivaroxaban (bleedings and recurrent venous thromboembolism), cumulative prevalence of post-thrombotic syndrome (PTS), primary patency, clinically driven target lesion revascularization rate, and other adverse events including all-cause mortality and vascular events (systemic emboli...
Source: Seminars in Thrombosis and Hemostasis - October 8, 2021 Category: Hematology Authors: Du, Jun Nie, Menglin Yan, Zhitong Fu, Jian Sun, Jianming Liu, Fanyun Tags: Review Article Source Type: research
Cardiovascular Mortality after Venous Thromboembolism: A Meta-Analysis of Prospective Cohort Studies
Semin Thromb Hemost DOI: 10.1055/s-0041-1733923Many studies from current literature show that cardiovascular diseases in patients with venous thromboembolism (VTE) are more frequent than in the general population without VTE. However, data summarizing the impact of cardiovascular diseases on mortality of patients with VTE are lacking. In this systematic review and meta-analysis, we aimed to determine the frequency and incidence rate of cardiovascular death in patients with VTE. MEDLINE and EMBASE were searched from January 1, 2000 to February 28, 2021. Eligible studies were observational prospective cohort studies includin...
Source: Seminars in Thrombosis and Hemostasis - October 8, 2021 Category: Hematology Authors: Noumegni, Steve Raoul Grangereau, Thomas Demir, Arzu Bressollette, Luc Couturaud, Francis Hoffmann, Cl ément Tags: Review Article Source Type: research
Arterial Thrombosis in Cancer Patients: An Update
Semin Thromb Hemost DOI: 10.1055/s-0041-1733927Cancer is associated with an increased incidence of both venous thromboembolism (VTE) and arterial thrombosis (cardiovascular events and ischemic stroke). Cancer-associated arterial thrombotic events are less well studied than VTE, but increasingly recognized, particularly in specific malignancies and in association with specific anticancer therapies. The pathogenesis of arterial thrombotic events in cancer is complex and involves generation of tumor-associated procoagulant factors and a variety of alterations in platelet function as well as in the coagulation and fibrinolytic...
Source: Seminars in Thrombosis and Hemostasis - August 31, 2021 Category: Hematology Authors: Franchini, Massimo Tufano, Antonella Casoria, Aniello Coppola, Antonio Tags: Review Article Source Type: research
ROTEM Testing for Direct Oral Anticoagulants
This article reviews the use of ROTEM in the setting of DOACs therapy, focusing on DOACs-associated bleeding and the use of this VHA for the management of reversal strategies for DOACs-associated anticoagulation. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Seminars in Thrombosis and Hemostasis - June 15, 2021 Category: Hematology Authors: Korpallov á, Barbora Samo š, Matej Bolek, Tom áš K ühnelová, Linda Škorňová, Ingrid Kubisz, Peter Sta ško, Ján Mok áň, Marián Tags: Review Article Source Type: research
Use of Glucocorticoids and Risk of Venous Thromboembolism: A Narrative Review
Semin Thromb Hemost DOI: 10.1055/s-0040-1722270Glucocorticoids are potent anti-inflammatory agents that are widely used for the treatment of many inflammatory, autoimmune, and neoplastic disorders. However, their beneficial effect is associated with several side effects, including an increased risk of cardiovascular complications, such as myocardial infarction and stroke. Whether their use also contributes to a procoagulant state, and therefore increases the risk of venous thromboembolism (VTE), is still a matter of debate. As an increased risk of venous thrombotic events is described in patients with Cushing's syndrome, w...
Source: Seminars in Thrombosis and Hemostasis - April 23, 2021 Category: Hematology Authors: Simion, Chiara Campello, Elena Bensi, Elisa Bellio, Andrea Pontarin, Anna Spiezia, Luca Simioni, Paolo Tags: Review Article Source Type: research
