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Source: Seminars in Thrombosis and Hemostasis
Condition: Thrombosis
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Total 49 results found since Jan 2013.
Fibrinolysis and Remote Ischemic Conditioning: Mechanisms and Treatment Perspectives in Stroke
In conclusion, a single RIC treatment does not affect fibrinolysis in the acute phase, whereas long-term RIC administration may increase endogenous fibrinolysis. Increased endogenous fibrinolysis is unlikely to be the mediator of the acute neuroprotective effect of RIC in stroke patients, whereas it may partly explain the reduced stroke recurrence associated with long-term RIC treatment. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Seminars in Thrombosis and Hemostasis - April 20, 2021 Category: Hematology Authors: Krag, Andreas Engel Blauenfeldt, Rolf Ankerlund Tags: Review Article Source Type: research
Direct Oral Anticoagulants Plasma Levels Measurement: Clinical Usefulness from Trials and Real-World Data
Semin Thromb Hemost 2021; 47: 150-160 DOI: 10.1055/s-0041-1723770Measurement of direct oral anticoagulants (DOACs) activity is not routinely necessary. Indeed, evaluation of DOACs plasmatic concentration is discouraged for the majority of patients, due to the lack of outcome data supporting this approach. Nevertheless, DOAC measurements may be useful in emergency situations such as serious bleeding events, need for urgent invasive procedures, and acute ischemic stroke or in managing anticoagulation in “special populations” not adequately studied in clinical trials, for example the very elderly or those at the extremes ...
Source: Seminars in Thrombosis and Hemostasis - February 26, 2021 Category: Hematology Authors: Renon, Francesca Rago, Anna Liccardo, Biagio D'Andrea, Antonello Riegler, Lucia Golino, Paolo Nigro, Gerardo Russo, Vincenzo Tags: Review Article Source Type: research
Clinical Performance of Nonvitamin K Antagonist Oral Anticoagulants in Real-World Obese Patients with Atrial Fibrillation
Semin Thromb Hemost DOI: 10.1055/s-0040-1715792The prevalence of both atrial fibrillation (AF) and obesity has steadily increased. Nonvitamin K antagonist oral anticoagulants (NOACs) have been shown to be more effective and safer than vitamin K antagonists (VKAs) for long-term stroke prevention in patients with nonvalvular AF. There are still limited data in the literature regarding performance of NOACs in obese patients with AF in the “real world.” The aim of our study was to compare the safety and effectiveness of NOACs versus well-controlled VKA therapy in obese AF patients in a “real-world” setting. Here, we ha...
Source: Seminars in Thrombosis and Hemostasis - October 26, 2020 Category: Hematology Authors: Russo, Vincenzo Bottino, Roberta Rago, Anna Papa, Andrea Antonio Liccardo, Biagio D'Onofrio, Antonio Golino, Paolo Nigro, Gerardo Tags: Review Article Source Type: research
Sulodexide versus Control and the Risk of Thrombotic and Hemorrhagic Events: Meta-Analysis of Randomized Trials
Semin Thromb Hemost DOI: 10.1055/s-0040-1716874Thrombotic cardiovascular disease (myocardial infarction [MI], stroke, and venous thromboembolism [VTE]) remains a major cause of death and disability. Sulodexide is an oral glycosaminoglycan containing heparan sulfate and dermatan sulfate. We conducted a systematic review and meta-analysis to determine the cardiovascular efficacy, and safety of sulodexide versus control in randomized controlled trials (RCTs). We searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials for RCTs reporting cardiovascular outcomes in patients receiving sulodexide versus co...
Source: Seminars in Thrombosis and Hemostasis - October 21, 2020 Category: Hematology Authors: Bikdeli, Behnood Chatterjee, Saurav Kirtane, Ajay J. Parikh, Sahil A. Andreozzi, Giuseppe M. Desai, Nihar R. Francese, Dominic P. Gibson, C Michael Piazza, Gregory Goldhaber, Samuel Z. Eikelboom, John W. Krumholz, Harlan M. Stone, Gregg W. Tags: Review Article Source Type: research
New-Onset Atrial Fibrillation in Sepsis: A Narrative Review
Semin Thromb Hemost DOI: 10.1055/s-0040-1714400Atrial fibrillation (AF) is a frequently identified arrhythmia during the course of sepsis. The aim of this narrative review is to assess the characteristics of patients with new-onset AF related to sepsis and the risk of stroke and death, to understand if there is a need for anticoagulation. We searched for studies on AF and sepsis on PubMed, the Cochrane database, and Web of Science, and 17 studies were included. The mean incidence of new-onset AF in patients with sepsis was 20.6% (14.7% in retrospective studies and 31.6% in prospective). Risk factors for new-onset AF includ...
Source: Seminars in Thrombosis and Hemostasis - September 22, 2020 Category: Hematology Authors: Aibar, Jesus Schulman, Sam Tags: Review Article Source Type: research
Red Blood Cell Distribution Width Is Associated with Collateral Flow and Final Infarct Volume in Acute Stroke with Large Artery Atherosclerosis
Semin Thromb Hemost DOI: 10.1055/s-0039-3400257 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Full text
Source: Seminars in Thrombosis and Hemostasis - December 12, 2019 Category: Hematology Authors: Hong, Lan Fang, Kun Ling, Yifeng Yang, Lumeng Cao, Wenjie Liu, Feifeng Li, Gang Parsons, Mark Cheng, Xin Dong, Qiang Tags: Letter to the Editor Source Type: research
Applications of Nanotechnology in the Diagnosis and Therapy of Stroke
Semin Thromb Hemost DOI: 10.1055/s-0039-3399568Stroke is a leading cause of death and disability worldwide. The classification of stroke subtypes is difficult but critical for the prediction of clinical course and patient management, and limited treatment options are available. There is an urgent need for improvements in both diagnosis and therapy. Strokes have rapidly evolving phases of damage involving unique compartments of the brain, which imposes severe limitations for current diagnostic and treatment procedures. The rapid development of nanotechnology in other areas of modern medicine has ignited a widespread interes...
Source: Seminars in Thrombosis and Hemostasis - December 12, 2019 Category: Hematology Authors: Landowski, Lila M. Niego, Be'eri Sutherland, Brad A. Hagemeyer, Christoph E. Howells, David W. Tags: Review Article Source Type: research
Heparin Bridging Therapy for Patients on Chronic Oral Anticoagulants in Periprocedural Settings
Semin Thromb Hemost DOI: 10.1055/s-0039-1696945Interruption of chronic anticoagulation due to the bleeding risk associated with an elective procedure may also lead to an elevated risk of thromboembolism. Periprocedural bridging with either unfractionated heparin or low-molecular weight heparin had been the mainstay of therapy for many patients receiving chronic warfarin treatment based on an estimation of a patient's thromboembolic risk. However, recent results from cohort studies and placebo-controlled randomized trials in the periprocedural use of heparin bridging for warfarin-treated patients reveal a consistent two- to...
Source: Seminars in Thrombosis and Hemostasis - December 11, 2019 Category: Hematology Authors: Nikolakopoulos, Ilias Spyropoulos, Alex C. Tags: Review Article Source Type: research
Using Artificial Intelligence to Manage Thrombosis Research, Diagnosis, and Clinical Management
Semin Thromb Hemost DOI: 10.1055/s-0039-1697949Thrombosis development in either arterial or venous system remains a major cause of death and disability worldwide. This poorly controlled in vivo clotting could result in many severe complications including myocardial infarction, venous thromboembolism, stroke, and cerebral venous thrombosis, to name a few. These conditions are collectively known as thromboembolic disorders (TEDs). Appropriate understanding of TEDs is challenging, as they are multifactorial and involve several and often different risk factors. Hence, it requires a collective effort and data from numerous rese...
Source: Seminars in Thrombosis and Hemostasis - September 27, 2019 Category: Hematology Authors: Mishra, Aastha Ashraf, Mohammad Zahid Tags: Review Article Source Type: research
Proton Pump Inhibitors and Dabigatran Therapy: Impact on Gastric Bleeding and Dabigatran Plasma Levels
This article reviews up to date data about the risk of gastric bleeding on dabigatran, the impact of PPI on the reduction of gastric bleeding, and the interaction between PPI and dabigatran leading to decreased dabigatran plasma levels. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text
Source: Seminars in Thrombosis and Hemostasis - September 18, 2019 Category: Hematology Authors: Bolek, Tom áš Samo š, Matej Škorňová, Ingrid Galajda, Peter Sta ško, Ján Kubisz, Peter Mok áň, Marián Tags: Review Article Source Type: research
Neutrophil Extracellular Traps in Arterial and Venous Thrombosis
Semin Thromb Hemost DOI: 10.1055/s-0038-1677040Thrombotic complications are still a major health risk worldwide. Our view on the pathophysiology of thrombosis has significantly changed since the discovery of neutrophil extracellular traps (NETs) and their prothrombotic characteristics. Generated by neutrophils that release their decondensed chromatin as a network of extracellular fibers, NETs promote thrombus formation by serving as a scaffold that activates platelets and coagulation. The thrombogenic involvement of NETs has been described in various settings of thrombosis, including stroke, myocardial infarction, and deep...
Source: Seminars in Thrombosis and Hemostasis - January 11, 2019 Category: Hematology Authors: Laridan, Elodie Martinod, Kimberly De Meyer, Simon F. Tags: Review Article Source Type: research
Sticky Platelet Syndrome: 35 Years of Growing Evidence
Semin Thromb Hemost DOI: 10.1055/s-0038-1676581Since the identification of antithrombin deficiency by Egeberg in 1956, ongoing research in prothrombotic defects continues to progress. Interestingly, past research has predominantly focused on coagulation factors and not on other components of the hemostatic system. The possible role of platelet function defects in the development of thrombotic events was suggested for the first time in the late 1970s, when an increased platelet adhesiveness and aggregation after epinephrine (EPI) and adenosine diphosphate (ADP) was found in a group of patients with unexplained transient isc...
Source: Seminars in Thrombosis and Hemostasis - January 10, 2019 Category: Hematology Authors: Kubisz, Peter Holly, Pavol Stasko, Jan Tags: Review Article Source Type: research
Surface Acoustic Wave-Based Microfluidic Coagulation Device for Monitoring Anticoagulant Therapy
Semin Thromb Hemost DOI: 10.1055/s-0038-1676318An universal coagulation test that reliably detects prolonged coagulation times in patients, regardless of which anticoagulant is administered, is not yet available. The authors developed a novel, miniaturized device utilizing surface acoustic waves (SAW) to detect clotting, and used it to develop a novel universal microfluidic coagulation test. Results from this assay were compared with results from standard coagulation assays to detect classical anticoagulants (unfractionated heparin, argatroban) and direct oral anticoagulants (dabigatran, rivaroxaban). The SAW-clotting time...
Source: Seminars in Thrombosis and Hemostasis - December 19, 2018 Category: Hematology Authors: Harder, Sebastian Santos, Sascha Meyer dos Krozer, Viktor Moll, Jochen Tags: Review Article Source Type: research
Feeling the Force: Measurements of Platelet Contraction and Their Diagnostic Implications
Semin Thromb Hemost DOI: 10.1055/s-0038-1676315In addition to the classical biological and biochemical framework, blood clots can also be considered as active biomaterials composed of dynamically contracting platelets, nascent polymeric fibrin that functions as a matrix scaffold, and entrapped blood cells. As platelets sense, rearrange, and apply forces to the surrounding microenvironment, they dramatically change the material properties of the nascent clot, increasing its stiffness by an order of magnitude. Hence, the mechanical properties of blood clots are intricately tied to the forces applied by individual platelets. ...
Source: Seminars in Thrombosis and Hemostasis - December 19, 2018 Category: Hematology Authors: Williams, Evelyn Kendall Oshinowo, Oluwamayokun Ravindran, Abhijit Lam, Wilbur A. Myers, David R. Tags: Review Article Source Type: research
Harms and Benefits of Using Aspirin for Primary Prevention of Cardiovascular Disease: A Narrative Overview
Semin Thromb Hemost DOI: 10.1055/s-0038-1675380Aspirin is one of the most often used drugs for prevention and treatment of a variety of thrombotic disorders. This narrative review aims to provide an overview of evidence highlighting potential benefits and relative harms of aspirin in primary prevention of cardiovascular disease. The authors summarize key findings of the ASPirin in Reducing Events in the Elderly (ASPREE) Investigator Group randomized trial and also provide a comparative overview of recent meta-analyses. Overall, all-cause mortality was largely heterogeneous, with some meta-analyses showing a modestly decrea...
Source: Seminars in Thrombosis and Hemostasis - October 22, 2018 Category: Hematology Authors: Lippi, Giuseppe Danese, Elisa Favaloro, Emmanuel J. Tags: Review Article Source Type: research
