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Lack Of Tafi Increases Brain Damage And Microparticle Generation After Thrombolytic Therapy In Ischemic Stroke
Thrombin-activatable fibrinolysis inhibitor (TAFI) plays an important role in coagulation and fibrinolysis. Whereas TAFI deficiency may lead to a haemorrhagic tendency, data from TAFI knockout mice (TAFI−/−) are controversial and no differences have been reported in these animals after ischemic stroke. There are also no data regarding the role of circulating microparticles (MPs) in TAFI−/−.
Source: Thrombosis Research - June 10, 2015 Category: Hematology Authors: Orbe J, Alexandru N, Roncal C, Belzunce M, Bibiot P, Rodriguez JA, Meijers JCM, Georgescu A, Paramo JA Source Type: research

The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model
Reperfusion injury after thrombolytic therapy can have adverse neurologic effects. The free-radical scavenger edaravone is used in combination with the recombinant tissue plasminogen activator alteplase to treat acute ischemic stroke. However, basic investigations of this combination use remain inadequate. Here, we used an in vivo model to investigate the effects of edaravone on alteplase-induced thrombolysis.
Source: Thrombosis Research - April 13, 2015 Category: Hematology Authors: Tsutomu Yamashita, Takumi Sato, Kumi Sakamoto, Hiromitsu Ishii, Junichiro Yamamoto Tags: Regular article Source Type: research