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Source: BMC Neurology
Condition: Thrombosis

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Total 32 results found since Jan 2013.

Left atrial volumes and associated stroke subtypes
This study is a standardized review of 633 patients admitted to the stroke service of a tertiary care hospital following a standardized stroke investigation and management pathway. Stroke subtypes were characterized using the Causative Classification System, using the hospitals online radiologic archival system with CCS certified stroke investigators. Patients with two mechanisms were excluded. Results: Patients with cardioembolic stroke had a higher proportion of atrial fibrillation (p
Source: BMC Neurology - October 18, 2013 Category: Neurology Authors: Quratulain ShaikhBilal AhmedMaryam AhmedJamal MaharMasood AhmadAyesha AhmedFarzin MajeedFariha AliMaria KhanAyeesha Kamal Source Type: research

The Norwegian tenecteplase stroke trial (NOR-TEST): randomised controlled trial of tenecteplase vs. alteplase in acute ischaemic stroke
Background: Alteplase is the only approved thrombolytic agent for acute ischaemic stroke. The overall benefit from alteplase is substantial, but some evidence indicates that alteplase also has negative effects on the ischaemic brain. Tenecteplase may be more effective and less harmfull than alteplase, but large randomised controlled phase 3 trials are lacking. The Norwegian Tenecteplase Stroke Trial (NOR-TEST) aims to compare efficacy and safety of tenecteplase vs. alteplase. Methods: NOR-TEST is a multi-centre PROBE (prospective randomised, open-label, blinded endpoint) trial designed to establish superiority of tenectepl...
Source: BMC Neurology - May 15, 2014 Category: Neurology Authors: Nicola LogalloChristopher KvistadAliona NacuHalvor NaessUlrike Waje-AndreassenJörg AsmussAnne Hege AamodtChristian LundMartin KurzOle Morten RønningRolf SalvesenTitto IdiculaLars Thomassen Source Type: research

Complex interventional treatment in a patient with atrial fibrillation and stroke caused by large carotid artery thrombus: a case report
Conclusion: Emergency carotid embolectomy together with thrombectomy and local thrombolytic rt-PA treatment may be a reasonable rescue therapy for carefully selected patients with large-vessel acute stroke. Further research is needed to establish the advantages and safety of surgical thrombectomy in patients with acute embolic occlusion of the carotid artery and ineffectiveness of or contraindications for systemic thrombolytic treatment.
Source: BMC Neurology - April 24, 2015 Category: Neurology Authors: Anetta Lasek-BalTomasz UrbanekDamian ZiajaAldona Warsz-WianeckaPrzemys¿aw PuzKrzysztof Ziaja Source Type: research

Rate of deep-vein thrombosis and pulmonary embolism during the care continuum in patients with acute ischemic stroke in the United States
Conclusions: Approximately 1% of patients with AIS experienced symptomatic in-hospital and/or post-discharge DVT/PE. Although 46% received prophylaxis in-hospital, only 6% received prophylaxis in the outpatient setting. This highlights the need for sustained thromboprophylaxis prescribing across the continuum of care.
Source: BMC Neurology - February 8, 2013 Category: Neurology Authors: Alpesh AminJay LinStephen ThompsonDaniel Wiederkehr Source Type: research

Stroke caused by an inflammatory thrombus: a case report
Stroke is the leading cause of mortality and disability worldwide. Several definite risk factors have been identified for stroke, although infectious factors might also contribute to stroke episodes through in...
Source: BMC Neurology - February 16, 2017 Category: Neurology Authors: Kai Shan and Wei Guo Source Type: research

Outcomes of thrombolytic therapy in acute ischemic stroke: mothership, drip-and-ship, and ship-and-drip paradigms
Chulalongkorn Stroke Center is a comprehensive stroke center (CSC) located in Bangkok, Thailand. Our stroke network consists of different levels of spoke hospitals, ranging from community hospitals where throm...
Source: BMC Neurology - February 3, 2020 Category: Neurology Authors: Naruchorn Kijpaisalratana, Aurauma Chutinet, Wasan Akarathanawat, Pakkawan Vongvasinkul and Nijasri C. Suwanwela Tags: Research article Source Type: research

Increase in national intravenous thrombolysis rates for ischaemic stroke between 2005 and 2012: is bigger better?
Intravenous thrombolytic therapy after ischaemic stroke significantly reduces mortality and morbidity. Actual thrombolysis rates are disappointingly low in many western countries. It has been suggested that hi...
Source: BMC Neurology - April 21, 2016 Category: Neurology Authors: S. Scherf, M. Limburg, R. Wimmers, I. Middelkoop and H. Lingsma Source Type: research

Clinical and radiological factors associated with unfavorable outcome after intravenous thrombolysis in patients with mild ischemic stroke
A significant proportion of patients with mild ischemic stroke become disabled despite receiving intravenous thrombolytic therapy. The purpose of this study was to assess the clinical and radiological factors ...
Source: BMC Neurology - March 15, 2018 Category: Neurology Authors: Dae-Hyun Kim, Deok-Soo Lee, Hyun-Wook Nah and Jae-Kwan Cha Tags: Research article Source Type: research

Status of prehospital delay and intravenous thrombolysis in the management of acute ischemic stroke in Nepal
The objective of this...
Source: BMC Neurology - July 9, 2019 Category: Neurology Authors: Gaurav Nepal, Jayant Kumar Yadav, Babin Basnet, Tirtha Man Shrestha, Ghanshyam Kharel and Rajeev Ojha Tags: Research article Source Type: research

Intravenous thrombolytic therapy for acute ischemic stroke in Hubei, China: a survey of thrombolysis rate and barriers
Rates of thrombolysis in most countries are well below best practice benchmarks. We aimed to investigate thrombolysis utilization and its associated factors in acute ischemic stroke (AIS) patients in Hubei pro...
Source: BMC Neurology - August 22, 2019 Category: Neurology Authors: Yanfeng Zhou, Shijiao Yan, Xingyue Song, Yanhong Gong, Wenzhen Li, Mengdie Wang, Xiaoxv Yin, Bo Hu and Zuxun Lu Tags: Research article Source Type: research

Blood-brain barrier integrity of stroke patients presenting in an extended time window
Current guidelines limit thrombolytic treatment of stroke to those patients who present within 4.5  h to minimize the risk of hemorrhagic complications. Risk of hemorrhage increases with increasing blood-brain ...
Source: BMC Neurology - February 13, 2020 Category: Neurology Authors: Jarrhett Butler, Parisa Heidari, Sarah Blayney, Emi Hitomi, Marie Luby and Richard Leigh Tags: Research article Source Type: research

A case report of thrombolysis resistance: thrombus ultrastructure in an ischemic stroke patient
Following acute ischemic stroke (AIS), approximately half of patients do not achieve recanalization after intravenous administration of tissue plasminogen activator (rt-PA). Thrombolysis resistance is a possib...
Source: BMC Neurology - April 14, 2020 Category: Neurology Authors: Ye Li, Heying Wang, Lili Zhao, Yating Jian, Meijuan Dang, Yu Jiang, Yiheng Zhang, Lei Zhang, Huqing Wang, Ru Zhang, Mingxia Chen and Guilian Zhang Tags: Case report Source Type: research

Prediction of deep vein thrombosis by ultrasonography and D-dimer in Asian patients with ischemic stroke
Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and...
Source: BMC Neurology - June 27, 2020 Category: Neurology Authors: Sang Hee Ha, Yeon-Jung Kim, Sung Hyuk Heo, Dae-il Chang and Bum Joon Kim Tags: Research article Source Type: research

Efficacy and safety of cinepazide maleate injection in patients with acute ischemic stroke: a multicenter, randomized, double-blind, placebo-controlled trial
Ischemic stroke is a leading cause of morbidity and mortality. Thrombolytic therapy improves disability and survival rates; however, to be effective, it must be given within 4.5  h of onset. Moreover, thromboly...
Source: BMC Neurology - July 14, 2020 Category: Neurology Authors: Jun Ni, Huisheng Chen, Guofang Chen, Yong Ji, Fei Yi, Zhuobo Zhang, Yi Yang, Jin Wu, Xueli Cai, Bei Shao, Jianfeng Wang, Yafang Liu, Deqin Geng, Xinhui Qu, Xiaohong Li, Yan Wei & hellip; Tags: Research article Source Type: research

Effects of diabetes mellitus complicated by admission hyperglycemia on clot histological composition and ultrastructure in patients with acute ischemic stroke
Type 2 diabetes mellitus (T2DM) affects the occurrence and prognosis of acute ischemic stroke (AIS). However, the impact of diabetes on thrombus characteristics is unclear. The relationship between the composi...
Source: BMC Neurology - April 5, 2022 Category: Neurology Authors: Qun Gao, Peng Qi, Junjie Wang, Shen Hu, Ximeng Yang, Jingwen Fan, Ling Li, Yao Lu, Jun Lu, Juan Chen and Daming Wang Tags: Research Source Type: research