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Sildenafil Reduces the Risk of Thromboembolic Events in HeartMate II Patients with Low-Level Hemolysis and Significantly Improves the Pulmonary Circulation.
Authors: Zayat R, Ahmad U, Stoppe C, Khattab MA, Arab F, Moza A, Tewarie L, Goetzenich A, Autschbach R, Schnoering H Abstract Low-level hemolysis (LLH) after left ventricular assist device implantation contributes to thromboembolic events (TE). Free plasma hemoglobin (fHb) scavenges nitric oxide (NO), which causes endothelial dysfunction and activates platelets. fHb also interacts with von Willebrand factor (vWF). We hypothesized that improved hemodynamic and enhanced NO signaling in HeartMate II (HMII) patients with LLH taking the phosphodiesterase-5 inhibitor sildenafil may reduce the risk of TE.From 2011 to 2015...
Source: International Heart Journal - October 12, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Sildenafil Is Associated With Reduced Device Thrombosis and Ischemic Stroke Despite Low-Level Hemolysis on Heart Mate II Support Original Articles
Conclusions: Sildenafil is associated with reduced device thrombosis and ischemic stroke during ongoing LLH on Heart Mate II support.
Source: Circulation: Heart Failure - November 1, 2017 Category: Cardiology Authors: Saeed, O., Rangasamy, S., Selevany, I., Madan, S., Fertel, J., Eisenberg, R., Aljoudi, M., Patel, S. R., Shin, J., Sims, D. B., Reyes Gil, M., Goldstein, D. J., Slepian, M. J., Billett, H. H., Jorde, U. P. Tags: Cardiomyopathy, Heart Failure, Ischemic Stroke Original Articles Source Type: research