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Protein C Promotor Haplotypes Associated with Large-Artery Atherosclerosis Stroke in Iranian Population
AbstractIschemic stroke (IS) is a complex disease regarding its risk factors; among those factors, genetics has an important role. Protein C (PC) is an important antithrombotic enzyme which its genetic variations disrupt the normal cascade of blood coagulation, resulting in thrombosis and increases the chance of stroke. Therefore, we aimed to investigate three single-nucleotide polymorphisms (SNPs) located in the core promoter of PC in order to find their role in this condition in the Iranian population. Blood samples from IS patients (n = 249) and healthy volunteers (n = 203) were collected. Biochemical analysis was p...
Source: Journal of Molecular Neuroscience - March 6, 2021 Category: Neuroscience Source Type: research