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Progressive thrombosis of cervical and intracranial arteries related to Ponatinib treatment for Chronic Myeloid Leukemia
Ponatinib is a third-generation Tyrosine Kinase Inhibitor (TKI), approved as first-line treatment for Chronic Myeloid Leukaemia (CML) chronic phase.Here we describe a CML patient with a history of subsequent TIAs and an ischemic stroke during Ponatinib treatment. Patient was admitted for a 3-day history of sudden onset left hemiparesis due to an acute ischemic stroke. MRI showed bilaterally the almost total absence of signal in the intracranial tract of anterior circulation and low signal of cerebral posterior circulation.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: E Spina, R Renna, LA Lanterna, ML Colleoni, V Andreone Tags: Case Report Source Type: research

Clinical Course of Cerebral Venous Thrombosis in Adult Acute Lymphoblastic Leukemia
Venous thromboembolism (VTE) is a frequent complication in patients with acute lymphoblastic leukemia (ALL). A significant proportion of patients develop cerebral venous thrombosis (CVT).
Source: Journal of Stroke and Cerebrovascular Diseases - April 28, 2015 Category: Neurology Authors: Susanna M. Zuurbier, Mandy N. Lauw, Jonathan M. Coutinho, Charles B.L.M. Majoie, Bronno van der Holt, Jan J. Cornelissen, Saskia Middeldorp, Bart J. Biemond, Jan Stam Source Type: research