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Cilostazol: a Review of Basic Mechanisms and Clinical Uses
AbstractPrimarily used in the treatment of intermittent claudication, cilostazol is a 2-oxyquinolone derivative that works through the inhibition of phosphodiesterase III and related increases in cyclic adenosine monophosphate (cAMP) levels. However, cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. It has been observed to exhibit antiplatelet, antiproliferative, vasodilatory, and ischemic-reperfusion protective properties. As such, cilostazol has been investigated for clinical use in a variety o...
Source: Cardiovascular Drugs and Therapy - April 16, 2021 Category: Cardiology Source Type: research

Abnormal haemodynamic postural response in patients with chronic heart failure
ConclusionsIn HF patients, the autonomic vasomotor response to postural stress is abnormal, more pronounced with increasing disease severity, and frequently associated with overt postural hypotension. These phenomena appear related to the cardiac condition rather than treatment.
Source: ESC Heart Failure - January 31, 2017 Category: Cardiology Authors: Anne ‐Sophie G.T. Bronzwaer, Lysander W.J. Bogert, Berend E. Westerhof, Jan J. Piek, Mat J.A.P. Daemen, Johannes J. Lieshout Tags: Original Research Article Source Type: research