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Source: Journal of Clinical Biochemistry and Nutrition
Condition: ALS
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Total 32 results found since Jan 2013.
Edaravone, a scavenger for multiple reactive oxygen species, reacts with singlet oxygen to yield 2-oxo-3-(phenylhydrazono)-butanoic acid
In this study, we investigated the reactivity of edaravone toward 1O2 and identified its reaction products. Edaravone showed a reactivity toward 1O2 greater than those of uric acid, histidine, and tryptophan, which are believed to be 1O2 scavengers in vivo. And we confirmed that 2-oxo-3-(phenylhydrazono)-butanoic acid was formed as an oxidation product. We propose a plausible mechanism for 2-oxo-3-(phenylhydrazono)-butanoic acid production by 1O2-induced edaravone oxidation. Since 2-oxo-3-(phenylhydrazono)-butanoic acid has already been identified as a radical-initiated oxidation product, free radical-induced oxidati...
Source: Journal of Clinical Biochemistry and Nutrition - June 13, 2022 Category: Nutrition Authors: Sakiko Amekura Kyouhei Shiozawa Chihiro Kiryu Yorihiro Yamamoto Akio Fujisawa Source Type: research
