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Scientists discover a new genetic form of ALS in children
(NIH/National Institute of Neurological Disorders and Stroke) In a study of 11 medical-mystery patients, an international team of researchers led by scientists at the National Institutes of Health and the Uniformed Services University (USU) discovered a new and unique form of amyotrophic lateral sclerosis (ALS). Unlike most cases of ALS, the disease began attacking these patients during childhood, worsened more slowly than usual, and was linked to a gene, called SPTLC1, that is part of the body's fat production system.
Source: EurekAlert! - Medicine and Health - May 31, 2021 Category: International Medicine & Public Health Source Type: news

NIH researchers link cases of ALS and FTD to a Huntington's disease-associated mutation
(NIH/National Institute of Neurological Disorders and Stroke) A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease. This large, international project, which included a collaboration between the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), opens a potentially new avenue for diagnosing and treating some individuals with FTD or ALS.
Source: EurekAlert! - Medicine and Health - December 4, 2020 Category: International Medicine & Public Health Source Type: news

AcuraStem receives fast-track SBIR grant
(AcuraStem, Inc.) AcuraStem, a fast-growing and innovative biotech company located in Monrovia, California, has been awarded a 3.7 million dollar Small Business Innovation Research (SBIR) Fast-Track grant (#R44NS105156) by the National Institute of Neurological Disorders and Stroke (NINDS) to continue research for the development of a small molecule therapeutic, 'AS2015', focused on treating patients with the genetic form of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) caused by expansion repeats in the gene C9ORF72.
Source: EurekAlert! - Medicine and Health - June 18, 2018 Category: International Medicine & Public Health Source Type: news

CRISPR helps find new genetic suspects behind ALS/FTD
(NIH/National Institute of Neurological Disorders and Stroke) NIH-funded researchers used the gene editing tool CRISPR to rapidly identify genes in the human genome that might modify the severity of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) caused by mutations in a gene called C9orf72. The results of the search uncovered a new set of genes that may hasten neuron death during the disease.
Source: EurekAlert! - Medicine and Health - March 12, 2018 Category: International Medicine & Public Health Source Type: news

Scripps Florida scientist and collaborators win $7 million grant to develop new ALS treatments
(Scripps Research Institute) Professor Matthew Disney of the Department of Chemistry on the Florida campus of The Scripps Research Institute (TSRI), together with scientists from Mayo Clinic's Florida campus and Johns Hopkins School of Medicine, has been awarded $7.2 million from the National Institute of Neurological Disorders and Stroke of The National Institutes of Health to create new RNA-based treatments for the most common form of amyotrophic lateral sclerosis (ALS), as well as a type of frontotemporal dementia (FTD).
Source: EurekAlert! - Medicine and Health - June 15, 2017 Category: International Medicine & Public Health Source Type: news

Rutgers Genetics Research Center awarded $6 million federal grant
(Rutgers University) The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a five-year grant worth up to $6,034,323 to RUCDR Infinite Biologics, a unit of Rutgers' Human Genetics Institute of New Jersey. With the new grant, the Rutgers operation will take over management of the NINDS stem cell repository. RUCDR also will provide a comprehensive range of stem-cell related services to researchers throughout the world investigating diseases including Parkinson's, amyotrophic lateral sclerosis and Huntington's.
Source: EurekAlert! - Medicine and Health - October 20, 2015 Category: Global & Universal Source Type: news

Scientists create mice with a major genetic cause of ALS and FTD
(NIH/National Institute of Neurological Disorders and Stroke) Scientists at Mayo Clinic, Jacksonville, Fla., created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both of which are caused by a mutation in the a gene called C9ORF72.
Source: EurekAlert! - Medicine and Health - May 22, 2015 Category: Global & Universal Source Type: news

Experimental stroke drug also shows promise for people with Lou Gehrig's disease
(University of Southern California - Health Sciences) Keck School of Medicine of University of Southern California neuroscientists have found that early muscle impairment related to Lou Gehrig's disease, also called amyotrophic lateral sclerosis, or ALS, in mice is proportional to the degree of damage to the blood-spinal cord barrier, which protects the central nervous system from toxins. Repairing damage to and restoring the blood-spinal cord barrier's integrity with an experimental neurovascular medicine being studied in human stroke patients appears to delay disease progression.
Source: EurekAlert! - Medicine and Health - March 3, 2014 Category: Global & Universal Source Type: news