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Patent foramen ovale closure reduces recurrent stroke risk in cryptogenic stroke: A systematic review and meta-analysis of randomized controlled trials.
CONCLUSION: PFO device closure in appropriately selected patients with moderate to severe right-to-left shunt and/or atrial septal aneurysm shows benefit with respect to recurrent strokes, particularly in younger patients. Further studies are essential to evaluate the impact of higher incidence of atrial fibrillation seen with the PFO closure device on long-term mortality and stroke rates. PMID: 29983901 [PubMed]
Source: World Journal of Cardiology - June 26, 2018 Category: Cardiology Authors: Anantha-Narayanan M, Anugula D, Das G Tags: World J Cardiol Source Type: research

Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated meta-analysis of randomized trials.
CONCLUSION: In certain groups of patients presenting with stroke, PFOC is beneficial in preventing future stroke compared to medical therapy. PMID: 31110604 [PubMed]
Source: World Journal of Cardiology - April 25, 2019 Category: Cardiology Authors: Dahal K, Yousuf A, Watti H, Liang B, Sharma S, Rijal J, Katikaneni P, Modi K, Tandon N, Azrin M, Lee J Tags: World J Cardiol Source Type: research

Closing patent foramen ovale in cryptogenic stroke: The underscored importance of other interatrial shunt variants.
Abstract Recent trials and metanalysis even not fully conclusive and still debated, at least suggested that mechanical device-based closure of patent foramen ovale (PFO) is more effective than medical therapy in prevent recurrence of stroke. In a proportion ranging from 20% to nearly 40% of patients in literature, PFO is associated to atrial septal aneurysm (ASA): ASA is a well-known entity often associated with additional fenestration. Additionally small atrial septal defects ("Flat ASD") can present with signs of paradoxical embolism and cannot be easily detected by transthoracic echocardiography or even by tran...
Source: World Journal of Cardiology - June 26, 2015 Category: Cardiology Authors: Rigatelli G, Rigatelli A Tags: World J Cardiol Source Type: research

Percutaneous closure of patent foramen ovale: "Closed" door after the last randomized trials?
In conclusion, our interpretation of these trials is that the use of a dedicated, specifically designed Amplatzer PFO device could possibly reduce the risk of stroke in patients with PFO and cryptogenic stroke. This consideration equally applies to patients who have no contraindications for anticoagulant or antithrombotic therapy. PMID: 24527181 [PubMed]
Source: World Journal of Cardiology - January 26, 2014 Category: Cardiology Authors: Hernandez J, Moreno R Tags: World J Cardiol Source Type: research

Large eustachian valve fostering paradoxical thromboembolism: passive bystander or serial partner in crime?
World J Cardiol. 2021 Jul 26;13(7):204-210. doi: 10.4330/wjc.v13.i7.204.ABSTRACTCatheter-based closure of patent foramen ovale (PFO) is more effective than medical therapy in the prevention of recurrent stroke[1]. It is likely that a proportion of patients evaluated for potential transcatheter PFO closure has actually different anatomical variants particularly common in the right atrium such as eustachian valve, Chiari network, Thebesian valve and Crista Terminalis. Notably, the eustachian valve may represent an increased risk factor for left circulation thromboembolism beyond that associated with PFO size and shunting. Su...
Source: World Journal of Cardiology - August 9, 2021 Category: Cardiology Authors: Eustaquio Maria Onorato Source Type: research

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