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From cryptogenic to ESUS: Toward precision medicine?
Rev Neurol (Paris). 2022 May 18:S0035-3787(22)00592-6. doi: 10.1016/j.neurol.2022.01.016. Online ahead of print.ABSTRACTCryptogenic infarctions are infarctions without a defined cause, despite a complete work-up. They differ from infarctions of undetermined causes, which may involve overlapping causes or an incomplete investigation. It is also different from uncommon heritable and non-heritable causes. The term embolic stroke of undetermined source (ESUS) proposed in 2014 is defined as a non-lacunar brain infarct without proximal arterial stenosis or cardioembolic sources. The major advantage of this definition compared to...
Source: Revue Neurologique - May 21, 2022 Category: Neurology Authors: S Timsit Source Type: research

Ovarian Cancer Presenting as Cryptogenic Stroke from Patent Foramen Ovale.
Abstract A 52-year-old woman experienced severe headache, confusion, nausea, dizziness, and diplopia for three days. Magnetic resonance imaging of the brain showed multiple acute and subacute infarcts suggestive of embolic events. Dermatological examination was notable for splinter hemorrhages and macular patches on the fingernails and feet, respectively. Further diagnostic imaging of the chest and abdomen revealed pulmonary emboli and an ovarian mass with omental deposits and splenic infarcts. Fine needle aspiration cytology and surgery confirmed a diagnosis of high grade serous adenocarcinoma of the ovary with c...
Source: Clin Med Res - July 18, 2019 Category: Research Authors: Potugari BR, Priyanka P, Komanapalli SD, Mercier RJ Tags: Clin Med Res Source Type: research

Diagnostic and Management Challenges in Patients with Left Atrial Myxoma (P1.229)
Conclusions:Cardiac myxomas are rare tumors, mostly arising from the left atrium that may cause ischemic or hemorrhagic strokes, intracranial aneurysms, or myxomatous metastases.Disclosure: Dr. Orjuela has nothing to disclose. Dr. McGinley has nothing to disclose. Dr. Sweis has nothing to disclose. Dr. Prabhu has nothing to disclose. Dr. Bakhos has nothing to disclose. Dr. Biller has received personal compensation in an editorial capacity for the Journal of Stroke and Cerebrovascular Diseases, Frontier in Neurology and Up-To-Date.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Orjuela, K., McGinley, M., Sweis, R., Prabhu, V., Bakhos, M., Biller, J. Tags: Cardiac Mechanisms and Complications of Stroke Source Type: research

A Case of Multiple Recurrent Ischemic Stroke in a Patient with Cholangiocarcinoma and Initiation of Anticoagulation Therapy for Secondary Stroke Prevention (P4.342)
CONCLUSIONS: Initiation of anticoagulation therapy and the optimal medications for secondary stroke prevention in cancer associated stroke remain controversial. Further randomized prospective studies are needed to establish treatment guidelines.Disclosure: Dr. Cheng has nothing to disclose. Dr. Then has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Cheng, J. Z., Then, R. Tags: Cerebrovascular Case Reports Source Type: research

E-051 acute ischemic stroke due to tumorigenic embolism treated with mechanical thrombectomy
ConclusionIn acute stroke secondary to malignant tumorigenic embolism, mechanical thrombectomy might be a safe and effective treatment option.DisclosuresB. Bell: None. A. Saad: None. K. Layton: None. S. Shamim: None. G. Snipes: None. K. Hesselrode: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Bell, B., Saad, A., Layton, K., Shamim, S., Snipes, G., Hesselrode, K. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

Running out of brain.
We describe here two cases of young men suffering a stroke after running a marathon and who were subsequently found to have a patent foramen ovale (PFO). We have reviewed the existing literature concerning stroke in those undertaking long-distance running, and suggest why PFO may have been important etiologically in our two patients. We tentatively suggest that individuals with a PFO who engage in long distance running may be at increased risk of stroke, independent of other cerebrovascular risk factors. PMID: 24739301 [PubMed - in process]
Source: Medical Physics - April 20, 2014 Category: Physics Authors: Ganesalingam J, Jenkins IH, Vaughan J Tags: J Sports Med Phys Fitness Source Type: research

Use of Transcranial Doppler (TCD) Ultrasound in the Neurocritical Care Unit
Transcranial Doppler (TCD) is a portable device that uses a handheld 2-MHz transducer. It is most commonly used in subarachnoid hemorrhage where cerebral blood flow velocities in major intracranial blood vessels are measured to detect vasospasm in the first 2 to 3 weeks. TCD is used to detect vasospasm in traumatic brain injury and post-tumor resection, measurement of cerebral autoregulation and cerebrovascular reactivity, diagnosis of acute arterial occlusions in stroke, screening for patent foramen ovale and monitoring of emboli. It can be used to detect abnormally high intracranial pressure and for confirmation of total...
Source: Neurosurgery Clinics of North America - April 19, 2013 Category: Neurosurgery Authors: Atul Kalanuria, Paul A. Nyquist, Rocco A. Armonda, Alexander Razumovsky Source Type: research