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Zoster-associated Prothrombotic Plasma Exosomes and Increased Stroke Risk
J Infect Dis. 2022 Oct 6:jiac405. doi: 10.1093/infdis/jiac405. Online ahead of print.ABSTRACTHerpes zoster (HZ, shingles) caused by varicella zoster virus (VZV) reactivation increases stroke risk for up to one-year post-HZ. The underlying mechanisms are unclear, however, the development of stroke distant from the site of zoster (e.g. thoracic, lumbar, sacral) that can occur months after resolution of rash points to a long-lasting, virus-induced soluble factor(s) that can trigger thrombosis and/or vasculitis. Herein, we investigated the content and contributions of circulating plasma exosomes from HZ and non-HZ patient samp...
Source: Herpes - October 6, 2022 Category: Infectious Diseases Authors: Andrew N Bubak Christina Coughlan Janelle Posey Anthony J Saviola Christy S Niemeyer Serena W R Lewis Sara Bustos Lopez Adriana Solano Stephen K Tyring Cassidy Delaney Keith B Neeves Ravi Mahalingam Kirk C Hansen Maria A Nagel Source Type: research

Complications of herpes zoster in immunocompetent older adults: Incidence in vaccine and placebo groups in two large phase 3 trials.
CONCLUSIONS: HZ/su reduces the risk of HZ-associated complications in older adults (NCT01165177; NCT01165229). PMID: 29463421 [PubMed - as supplied by publisher]
Source: Vaccine - February 17, 2018 Category: Allergy & Immunology Authors: Kovac M, Lal H, Cunningham AL, Levin MJ, Johnson RW, Campora L, Volpi A, Heineman TC, ZOE-50/70 Study Group Tags: Vaccine Source Type: research