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Molecules, Vol. 26, Pages 4700: The Therapeutic Potential of Celastrol in Central Nervous System Disorders: Highlights from In Vitro and In Vivo Approaches
Trabace Celastrol, the most abundant compound derived from the root of Tripterygium wilfordii, largely used in traditional Chinese medicine, has shown preclinical and clinical efficacy for a broad range of disorders, acting via numerous mechanisms, including the induction of the expression of several neuroprotective factors, the inhibition of cellular apoptosis, and the decrease of reactive oxygen species (ROS). Given the crucial implication of these pathways in the pathogenesis of Central Nervous System disorders, both in vitro and in vivo studies have focused their attention on the possible use of this compound in th...
Source: Molecules - August 3, 2021 Category: Chemistry Authors: Stefania Schiavone Maria Grazia Morgese Paolo Tucci Luigia Trabace Tags: Review Source Type: research

Reliability and validity of Six-Spot Step Test (SSST) in stroke survivors
CONCLUSIONS: The SSST was a reliable test and showed a significant correlation with FMA-LE scores, BBS scores, and TUG test times in stroke survivors.CLINICAL REHABILITATION IMPACT: The SSST can be used to assess the advanced balance control of stroke survivors.PMID:34128605 | DOI:10.23736/S1973-9087.21.06799-X
Source: European Journal of Physical and Rehabilitation Medicine - June 15, 2021 Category: Rehabilitation Authors: Tai Wa Liu Shamay S Ng Ka-Yuen Cheung Ming-Yeung Cheung Ryan N Hung Man-Fai Lam Adrian T Wong Cynthia Y Lai Mimi M Tse Source Type: research

Spectrum of neuroimaging findings in COVID-19.
Abstract An outbreak of corona virus disease 2019 (COVID-19) began in China in December 2019, and rapidly spread to become a worldwide pandemic. Neurological complications encountered in hospitalized patients include acute arterial ischemic cerebrovascular stroke, cerebral venous thrombosis, critical illness-associated cerebral microbleeds, hypertensive hemorrhagic posterior reversible encephalopathy, meningoencephalitis/flare up of infections, flare up of multiple sclerosis, acute disseminated encephalomyelitis, cerebral hemodynamic/hypoxic changes such as watershed ischemic changes and hypoxic ischemic encephalo...
Source: The British Journal of Radiology - December 13, 2020 Category: Radiology Authors: El Beltagi AH, Vattoth S, Abdelhady M, Ahmed I, Paksoy Y, Abou Kamar M, Alsoub H, Almaslamani M, Alkhal AL, Own A, Elsotouhy A Tags: Br J Radiol Source Type: research

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