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Condition: Translocation
Therapy: Chemotherapy
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Total 2 results found since Jan 2013.
Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein
. Mchaourab
ATP binding cassette (ABC) transporters of the exporter class harness the energy of ATP hydrolysis in the nucleotide-binding domains (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain (TMD). Although numerous investigations have described the mechanism of ATP hydrolysis and defined the architecture of ABC exporters, a detailed structural dynamic understanding of the transduction of ATP energy to the work of substrate translocation remains elusive. Here we used double electron–electron resonance and molecular dynamics simulations to describe the ATP- and substr...
Source: Nature - March 13, 2017 Category: Research Authors: Brandy Verhalen Reza Dastvan Sundarapandian Thangapandian Yelena Peskova Hanane A. Koteiche Robert K. Nakamoto Emad Tajkhorshid Hassane S. Mchaourab Tags: Letter Source Type: research
