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Introduction to the Special Issue "The Brain-Gut Axis"
Cell Mol Neurobiol. 2021 Oct 15. doi: 10.1007/s10571-021-01155-7. Online ahead of print.ABSTRACTThis special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications in variety of neurological disorders. There are intimate connections between the brain and the digestive system. Gut microbiota dysbiosis activates the intestinal immune system, enhances intestinal permeability and bacterial translocation, leading to neuroinflammation, epigen...
Source: Cellular and Molecular Neurobiology - October 15, 2021 Category: Cytology Authors: Yvette Tach é Juan M Saavedra Source Type: research

Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation
Cell Mol Neurobiol. 2021 Aug 3. doi: 10.1007/s10571-021-01134-y. Online ahead of print.ABSTRACTPrevention of the nuclear translocation of ANXA1 with Tat-NTS was recently reported to alleviate neuronal injury and protect against cerebral stroke. However, the role that Tat-NTS plays in the occurrence and development of gliomas still needs to be elucidated. Therefore, human glioblastoma (GB) cells were treated with various concentrations of Tat-NTS for 24 h, and cell proliferation, migration and invasion were assessed with CCK-8 and Transwell assays. The nuclear translocation of ANXA1 was evaluated by subcellular extraction a...
Source: Cellular and Molecular Neurobiology - August 4, 2021 Category: Cytology Authors: Zhenzhao Luo Li Liu Xing Li Weiqun Chen Zhongxin Lu Source Type: research

Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy.
In conclusion, MSCs potentially protect the cortical neurons from OGD-injury in vitro, through rescuing neurons from the cell death of parthanatos, necroptosis, and apoptosis, but not autophagy, which could provide some evidence to the mechanism explanation on stem cell treatment for ischemic stroke. PMID: 27044018 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - April 3, 2016 Category: Cytology Authors: Kong D, Zhu J, Liu Q, Jiang Y, Xu L, Luo N, Zhao Z, Zhai Q, Zhang H, Zhu M, Liu X Tags: Cell Mol Neurobiol Source Type: research

Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-κB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis.
Abstract Neural stem cell (NSC) transplantation is a promising approach to repair the damaged brain after hemorrhagic stroke; however, it is largely limited by the poor survival of donor cells. Breakdown products of the hematoma and subsequent iron overload contribute to the impairment of survival of neural cells. There is little information regarding the mechanism involved in the death of grafted cells. Furthermore, therapeutic research targeted to improving the survival of grafted neural stem cells (NSCs) is strikingly lacking. Here, we showed that iron overload induced apoptosis of C17.2 cells, a cell line orig...
Source: Cellular and Molecular Neurobiology - March 10, 2016 Category: Cytology Authors: Xie Z, Han P, Cui Z, Wang B, Zhong Z, Sun Y, Yang G, Sun Q, Bian L Tags: Cell Mol Neurobiol Source Type: research