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Introduction to the Special Issue "The Brain-Gut Axis"
Cell Mol Neurobiol. 2021 Oct 15. doi: 10.1007/s10571-021-01155-7. Online ahead of print.ABSTRACTThis special Issue presents comprehensive and state-of-the-art advances in supporting the crucial role of the bidirectional interactions between the Brain-Gut Axis in health and diseases with an emphasis on the microbiome-gut-brain axis and its implications in variety of neurological disorders. There are intimate connections between the brain and the digestive system. Gut microbiota dysbiosis activates the intestinal immune system, enhances intestinal permeability and bacterial translocation, leading to neuroinflammation, epigen...
Source: Molecular Medicine - October 15, 2021 Category: Molecular Biology Authors: Yvette Tach é Juan M Saavedra Source Type: research

NF ‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells
Mol Med Rep. 2021 Nov;24(5):814. doi: 10.3892/mmr.2021.12454. Epub 2021 Sep 24.ABSTRACTThe results of a previous study demonstrated that heat stress (HS) triggered oxidative stress, which in turn induced the apoptosis of epithelial cells. These results uncovered a novel mechanism underlying the activation of NF‑κB in primary human umbilical vein endothelial cells. The present study aimed to further investigate the role of NF‑κB/IκBα signaling pathways in the inhibition of HS‑induced reactive oxygen species (ROS) generation and cytotoxicity in endothelial cells. The results of the present study demonstrated that H...
Source: Molecular Medicine - September 24, 2021 Category: Molecular Biology Authors: Weidang Xie Wei Huang Shumin Cai Hui Chen Weijun Fu Zhongqing Chen Yanan Liu Source Type: research

Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis
CONCLUSION: This study presents that depleting SOX2 improves IS via PVT1/miR-24-3p/STAT3 axis which may broaden our knowledge about the mechanisms of SOX2/PVT1/miR-24-3p/STAT3 axis and provide a reference of therapy for IS.PMID:34521353 | DOI:10.1186/s10020-021-00346-8
Source: Molecular Medicine - September 15, 2021 Category: Molecular Biology Authors: Zhongjun Chen Tieping Fan Xusheng Zhao Zhichen Zhang Source Type: research

Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke
J Cell Mol Med. 2021 Sep 12. doi: 10.1111/jcmm.16923. Online ahead of print.ABSTRACTOridonin, a natural diterpenoid compound extracted from a Chinese herb, has been proved to exert anti-oxidative stress effects in various disease models. The aim of the present study was to investigate the protective effects of oridonin on oxidative stress-induced endothelial injury in ischaemic stroke. We found oridonin repaired blood-brain barrier (BBB) integrity presented with upregulation of tight junction proteins (TJ proteins) expression, inhibited the infiltration of periphery inflammatory cells and neuroinflammation and thereby redu...
Source: Molecular Medicine - September 13, 2021 Category: Molecular Biology Authors: Lei Li Shu-Qi Cheng Wei Guo Zhen-Yu Cai Yu-Qin Sun Xin-Xin Huang Jin Yang Juan Ji Ya-Yun Chen Yin-Feng Dong Hong Cheng Xiu-Lan Sun Source Type: research

OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF- κB signalling pathway in acute ischaemic stroke rats
CONCLUSIONS: OTULIN provides a new potential therapeutic target for EA to alleviate acute ischaemic stroke-induced brain injury and the activation of glial cells, which are related to suppression of the NF-κB signalling pathway.PMID:33836646 | DOI:10.1186/s10020-021-00297-0
Source: Molecular Medicine - April 10, 2021 Category: Molecular Biology Authors: Hongbei Xu You Wang Yong Luo Source Type: research