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Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke
Conclusions and implicationsThe data in this study demonstrated that Nef might have therapeutic potential for ischemic stroke and may exert its protective role through mitochondrial protection. In addition, this protection might be attributed to the modulation of Nrf2 signalling.
Source: British Journal of Pharmacology - November 10, 2018 Category: Drugs & Pharmacology Authors: Chuanhong Wu, Jianxin Chen, Ruocong Yang, Feipeng Duan, Shaojing Li, Xiuping Chen Tags: RESEARCH PAPER Source Type: research

Drp‐1, a potential therapeutic target for brain ischemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 may increase the resistance of neurons of hippocampal CA3 affected by global ischemia and the tolerance conferred by IPC highlight Drp‐1 as a potential target for translocation to effective therapy for brain ischemic stroke.
Source: British Journal of Pharmacology - February 24, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research

Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia
Conclusions and ImplicationsCinnamaldehyde protects against cerebral ischaemia injury by inhibiting inflammation, partly mediated by reducing the expression of toll‐like receptor 4, tumour necrosis receptor‐associated factor 6 and the nuclear translocation of NF‐κB. Our findings suggest that cinnamaldehyde may serve as a new candidate for further development as a treatment for stroke.
Source: British Journal of Pharmacology - October 14, 2015 Category: Drugs & Pharmacology Authors: Jingru Zhao, Xiangjian Zhang, Lipeng Dong, Ya Wen, Xiufen Zheng, Cong Zhang, Rong Chen, Ye Zhang, Yaoru Li, Tingting He, Xingyuan Zhu, Litao Li Tags: RESEARCH PAPER Source Type: research

Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischemia
Conclusions and ImplicationsCinnamaldehyde protects against cerebral ischemia injury by inhibiting inflammation and, probably, this is partly mediated by reducing the expression of TLR4/TRAF6 and nuclear translocation of NF‐κB. Our findings suggest that cinnamaldehyde may serve as a new candidate for further development as a stroke treatment.
Source: British Journal of Pharmacology - August 1, 2015 Category: Drugs & Pharmacology Authors: Jingru Zhao, Xiangjian Zhang, Lipeng Dong, Ya Wen, Xiufen Zheng, Cong Zhang, Rong Chen, Ye Zhang, Yaoru Li, Tingting He, Xingyuan Zhu, Litao Li Tags: RESEARCH PAPER Source Type: research