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Conventional protein kinase Cβ‐mediated phosphorylation inhibits collapsin response‐mediated protein 2 proteolysis and alleviates ischemic injury in cultured cortical neurons and ischemic stroke‐induced mice
In this study, we explored the regulation of CRMP2 phosphorylation and proteolysis by cPKCβ, and their role in ischemic injury of oxygen–glucose deprivation (OGD)‐treated cortical neurons and brains of mice with middle cerebral artery occlusion‐induced ischemic stroke. The results demonstrated that cPKCβ‐mediated CRMP2 phosphorylation via the cPKCβ‐selective activator 12‐deoxyphorbol 13‐phenylacetate 20‐acetate (DOPPA) and inhibition of calpain‐mediated CRMP2 proteolysis by calpeptin and a fusing peptide containing TAT peptide and the calpain cleavage site of CRMP2 (TAT‐CRMP2) protected neurons again...
Source: Journal of Neurochemistry - February 11, 2016 Category: Neurology Authors: Xuan Yang, Xinxin Zhang, Yun Li, Song Han, David W. Howells, Shujuan Li, Junfa Li Tags: Original Article Source Type: research

The protective role of Isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen glucose deprivation
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 18, 2015 Category: Neurology Authors: Wenlu Li, Zhigang Chen, Min Yan, Ping He, Zhong Chen, Haibin Dai Tags: Original Article Source Type: research

Hydrogen sulfide protects blood–brain barrier integrity following cerebral ischemia
In conclusion, H2S donors protected BBB integrity following experimental stroke possibly by acting through NF‐κB inhibition to suppress neuroinflammation induction of MMP9 and NOX4‐derived free radicals. To determine H2S effects on blood–brain barrier (BBB) disruption following stroke, we used two structurally unrelated H2S donors ADT and NaHS. Both ADT and NaHS remarkably protected BBB integrity following experimental stroke. The slow‐releasing donor ADT also reduced post‐ischemic inflammation‐induced expression and activity of MMP9 and NOX4 in the ischemic brain possibly by inhibiting NF‐κB activation. ...
Source: Journal of Neurochemistry - March 27, 2014 Category: Neurology Authors: Yali Wang, Jia Jia, Guizhen Ao, Lifang Hu, Hui Liu, Yunqi Xiao, Huaping Du, Nabil J. Alkayed, Chun‐Feng Liu, Jian Cheng Tags: Original Article Source Type: research

Hydrogen sulfide protects blood‐brain barrier integrity following cerebral ischemia
In conclusion, H2S donors protected BBB integrity following experimental stroke possibly by acting through NF‐κB inhibition to suppress neuroinflammation induction of MMP9 and NOX4‐derived free radicals. This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - February 23, 2014 Category: Neurology Authors: Yali Wang, Jia Jia, Guizhen Ao, Lifang Hu, Hui Liu, Yunqi Xiao, Huaping Du, Nabil J. Alkayed, Chunfeng Liu, Jian Cheng Tags: Original Article Source Type: research

Functional up‐regulation of endopeptidase neurolysin during post‐acute and early recovery phases of experimental stroke in mouse brain
This study also documents sustained functional up‐regulation of neurolysin in frontoparietal cortical membranes for at least 7 days after stroke, which appears not to be transcriptionally or translationally regulated, but rather depends on translocation of cytosolic neurolysin to the membranes and mitochondria. Considering diversity of endogenous neurolysin substrates (neurotensin, bradykinin, angiotensins I/II, substance P, hemopressin, dynorphin A(1‐8), metorphamide, somatostatin) and the well‐documented role of these peptidergic systems in pathogenesis of stroke, resistance to ischemic injury and/or post‐stroke...
Source: Journal of Neurochemistry - November 19, 2013 Category: Neurology Authors: Mamoon Rashid, Naomi J. Wangler, Li Yang, Kaushik Shah, Thiruma V. Arumugam, Thomas J. Abbruscato, Vardan T. Karamyan Tags: Original Article Source Type: research

Functional upregulation of endopeptidase neurolysin during post‐acute and early recovery phases of experimental stroke in mouse brain
This study also documents sustained functional upregulation of neurolysin in frontoparietal cortical membranes up to 7 days after stroke, which appears not to be transcriptionally or translationally regulated, but rather depends on translocation of cytosolic neurolysin to the membranes and mitochondria. Considering diversity of endogenous neurolysin substrates (neurotensin, bradykinin, angiotensins I/II, substance P, hemopressin, dynorphin A(1‐8), metorphamide, somatostatin) and the well‐documented role of these peptidergic systems in pathogenesis of stroke, resistance to ischemic injury and/or post‐stroke brain reco...
Source: Journal of Neurochemistry - October 27, 2013 Category: Neurology Authors: Mamoon Rashid, Naomi J. Wangler, Li Yang, Kaushik Shah, Thiruma V. Arumugam, Thomas J. Abbruscato, Vardan T. Karamyan Tags: Original Article Source Type: research

The Parkinson's disease‐associated gene PINK1 protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1
This study demonstrates that PINK1 prevents ischemic damage in neurons by attenuating mitochondrial translocation of Drp1, which maintains mitochondrial function and inhibits ischemia‐induced mitochondrial fission. These novel findings implicate a pivotal role of PINK1 regulated mitochondrial dynamics in the pathology of ischemic stroke. This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - June 16, 2013 Category: Neurology Authors: Yanxin Zhao, Fangzhe Chen, Shufen Chen, Xueyuan Liu, Mei Cui, Qiang Dong Tags: Original Article Source Type: research