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Carotid plaque hemorrhage on MRI strongly predicts recurrent ischemia and stroke
Abstract OBJECTIVES:There is a recognized need to improve selection of patients with carotid artery stenosis for carotid endarterectomy (CEA). We assessed the value of MRI defined carotid plaque hemorrhage (MRIPH) to predict recurrent ipsilateral cerebral ischemic events, and stroke in symptomatic carotid stenosis. METHODS:179 symptomatic patients with ≥50% stenosis were prospectively recruited, underwent carotid MRI and were clinically followed up until CEA, death or ischemic event. MRIPH was diagnosed if the plaque signal intensity was >150% that of the adjacent muscle. Event‐free survival analysis was done using ...
Source: Annals of Neurology - March 6, 2013 Category: Neurology Authors: Akram A. Hosseini, Neghal Kandiyil, Shane T. MacSweeney, Nishath Altaf, Dorothee P. Auer Tags: Research Article Source Type: research

Carotid artery stenting in recently symptomatic patients.
Abstract Treatment of acute stroke is time-dependent, with the best outcomes resulting from the earliest interventions. However, for patients with acute ischemic stroke due to a high-grade stenosis of the internal carotid artery, despite maximal medical treatment, an effective intervention to improve their neurologic symptoms and clinical outcome has not yet been established. There are two major concerns: first, cerebral revascularization in the acute stage remains challenging because of the possibility that hemorrhagic infarction or hyperperfusion syndrome will occur after revascularization; second, alarms about ...
Source: The Journal of Cardiovascular Surgery - January 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Setacci C, de Donato G, Setacci F, Sirignano P, Galzerano G, Borrelli MP, Cappelli A Tags: J Cardiovasc Surg (Torino) Source Type: research

Short telomere length in blood leukocytes contributes to the presence of atherothrombotic stroke and hemorrhagic stroke and risk of post-stroke death
Conclusions—Shorter telomere length may serve as a potential marker for the presence of atherothrombotic and hemorrhagic stroke and for the risk of post-stroke death.
Source: Clinical Science - January 16, 2013 Category: Biomedical Science Authors: W Zhang, Y Chen, Y Wang, P Liu, M Zhang, C Zhang, F B Hu, R Hui Source Type: research

Features of Unstable Carotid Plaque During and After the Hyperacute Period Following TIA/Stroke
Conclusion: Patients undergoing surgery ≤14 days had a significantly higher overall burden of high risk plaque features compared with those undergoing delayed CEA. However, the secondary upsurge across a range of unstable plaque features in patients undergoing CEA after ≥29 days had elapsed suggests that the relationship between recency of symptoms and plaque histology is more complex than had been anticipated in previous studies.
Source: European Journal of Vascular and Endovascular Surgery - December 26, 2012 Category: Surgery Authors: M.K. Salem, R.D. Sayers, M.J. Bown, K. West, D. Moore, T.G. Robinson, A.R. Naylor Tags: Carotid Disease Source Type: research

Features of Unstable Carotid Plaque During and After the Hyperacute Period Following TIA/Stroke.
CONCLUSION: Patients undergoing surgery ≤14 days had a significantly higher overall burden of high risk plaque features compared with those undergoing delayed CEA. However, the secondary upsurge across a range of unstable plaque features in patients undergoing CEA after ≥29 days had elapsed suggests that the relationship between recency of symptoms and plaque histology is more complex than had been anticipated in previous studies. PMID: 23270859 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - December 24, 2012 Category: Surgery Authors: Salem MK, Sayers RD, Bown MJ, West K, Moore D, Robinson TG, Naylor AR Tags: Eur J Vasc Endovasc Surg Source Type: research

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