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Fatal Adverse Events of Dabigatran Combined With Aspirin in Elderly Patients: An Analysis Using Data From VigiBase
Conclusion: The fatal adverse events associated with the combined use of dabigatran and aspirin in elderly patients were mainly serious bleeding events, which often occurred within 1 month. Most of these cases had medication errors and most of the patients had multiple diseases, medications, or other conditions at the same time that increase the risk of bleeding. It is suggested that prescription of dabigatran and aspirin in elderly patients should go along with alertness for medication errors, care for correct dose or control of other bleeding risk factors, and the combined medication time should be as short as possible ...
Source: Frontiers in Pharmacology - December 22, 2021 Category: Drugs & Pharmacology Source Type: research

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Safety and Feasibility of a Novel Transnasal Cooling Device to Induce Normothermia in Febrile Cerebrovascular Patients
ConclusionsInducing normothermia with a novel transnasal TMD appears to be safe, feasible and not associated with significant shivering. A multicenter trial testing the ability of the CoolStat to maintain normothermia for 24  h is currently underway.
Source: Neurocritical Care - July 13, 2020 Category: Neurology Source Type: research

Response by de Ridder et al to Letter Regarding Article, “PAIS 2 (Paracetamol Acetaminophen in Stroke 2) Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial” Letter to the Editor
Source: Stroke - June 26, 2017 Category: Neurology Authors: Inger R. de Ridder, Diederik W.J. Dippel, H. Bart van der Worp Tags: Pharmacology, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Letters to the Editor Source Type: research

PAIS 2 (Paracetamol Acetaminophen in Stroke 2) Clinical Sciences
Conclusions—Treatment with high-dose paracetamol seemed to be safe. The effect of high-dose paracetamol on functional outcome remains uncertain. Therefore, a large trial of early treatment with high-dose paracetamol is still needed.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR2365.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Inger R. de Ridder, Heleen M. den Hertog, H. Maarten A. van Gemert, A.H.C.M.L. (Tobien) Schreuder, Annemieke Ruitenberg, E. (Lisette) Maasland, Ritu Saxena, Jordie H. van Tuijl, Ben P.W. Jansen, Renske M. Van den Berg-Vos, Frederique Vermeij, Peter J. Kou Tags: Pharmacology, Meta Analysis, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

What Causes Hyperammonemia?
Discussion Reye’s syndrome (RS)is named for Dr. Douglas Reye who along with Drs. G. Morgan and J. Baral described encephalopathy and fatty accumulation and degeneration in children in a 1963 Lancet article. RS usually affects children but can occur at all ages. All organs can be affected but the liver and brain are primarily affected causing liver failure and encephalopathy as toxic metabolites (especially ammonia) accumulate, and intracranial hypertension and cerebral edema occurs. As the ammonia levels begin to rise (> 100 mg/dL) patients lose their appetite, have nausea and emesis and mental status changes whic...
Source: PediatricEducation.org - February 20, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Analgesia in Neurocritical Care: An International Survey and Practice Audit*
Conclusions: Opiates and acetaminophen are preferred analgesic agents, and gabapentin is a contextual third choice, in neurocritically ill patients. Other agents are rarely prescribed. The discordance in physician self-reports and objective audits suggest that pain management optimization studies are warranted.
Source: Critical Care Medicine - April 16, 2016 Category: Emergency Medicine Tags: Neurologic Critical Care Source Type: research

Medtech approvals: FDA releases August 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in August 2015: Summary of PMA Originals & Supplements Approved Originals: 2 Supplements: 70 Summary of PMA Originals Under Review Total Under Review: 57 Total Active: 28 Total On Hold: 29 Summary of PMA Supplements Under Review Total Under Review: 569 Total Active: 422 Total On Hold: 147 Summary of All PMA Submissions Originals: 5 Supplements: 90 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 70 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 229.0 FDA Time: 130...
Source: Mass Device - October 23, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Pre-Market Approval (PMA) Regulatory/Compliance Source Type: news

Fever Management Practices of Neuroscience Nurses: What Has Changed?
This study encourages the development of a stepwise approach to neuro-specific protocols for fever management. Furthermore, it shows the continuing need to promote further education and specialty training among nurses and encourage collaboration with physicians to establish best practices.
Source: Journal of Neuroscience Nursing - February 27, 2015 Category: Neuroscience Tags: Article Source Type: research

Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): Protocol for a randomized, placebo‐controlled, double‐blind clinical trial to assess the effect of high‐dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36·5°C or above
DiscussionIf high‐dose paracetamol will be proven effective, a simple, safe, and extremely cheap therapy will be available for many patients with acute stroke worldwide.
Source: International Journal of Stroke - May 22, 2013 Category: Neurology Authors: Inger R. Ridder, Frank Jan Jong, Heleen M. Hertog, Hester F. Lingsma, H. Maarten A. Gemert, A. H. C. M. L. (Tobien) Schreuder, Annemieke Ruitenberg, E. (Lisette) Maasland, Ritu Saxena, Peter Oomes, Jordie Tuijl, Peter J. Koudstaal, L. Jaap Kappelle, Ale A Tags: Protocols Source Type: research