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Source: Journal of Neurosurgery
Condition: Hemorrhagic Stroke
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Total 231 results found since Jan 2013.
Interventional outcomes for patients eligible for entry into the ARUBA clinical trial: a systematic review and meta-analysis
CONCLUSIONS: Intervention for unruptured AVMs affords acceptable outcomes for appropriately selected patients. The risk of hemorrhage following intervention compared favorably to the natural history of unruptured AVMs. The included studies were retrospective and varied in treatment and AVM characteristics, thereby limiting the generalizability of their data. Future studies from prospective registries may clarify patient, nidus, and intervention selection criteria that will refine the challenging management of patients with unruptured AVMs.PMID:34740184 | DOI:10.3171/2021.7.JNS211186
Source: Journal of Neurosurgery - November 5, 2021 Category: Neurosurgery Authors: M Harrison Snyder Ching-Jen Chen Faraz Farzad Natasha Ironside Ryan T Kellogg Andrew M Southerland Min S Park Jason P Sheehan Dale Ding Source Type: research
Comparative study of on-label versus off-label treatment of intracranial aneurysms with the Pipeline embolization device
CONCLUSIONS: In real-world practice, off-label use of PED is common and can achieve similar efficacy as on-label use. However, in aggregate, off-label use was found to carry an increased rate of ischemic complications. With judicious attention to safety and individual patient characteristics, these results highlight the scale and general feasibility of off-label PED use by experts.PMID:35090133 | DOI:10.3171/2021.11.JNS212481
Source: Journal of Neurosurgery - January 28, 2022 Category: Neurosurgery Authors: Samuel J Cler David C Lauzier Arindam R Chatterjee Joshua W Osbun Christopher J Moran Akash P Kansagra Source Type: research
Activation of the NLRP3/IL-1 β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats
CONCLUSIONS: To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.PMID:35594890 | DOI:10.3171/2022.4.JNS212945
Source: Journal of Neurosurgery - May 20, 2022 Category: Neurosurgery Authors: Tadashi Yamaguchi Takeshi Miyamoto Eiji Shikata Izumi Yamaguchi Kenji Shimada Kenji Yagi Yoshiteru Tada Masaaki Korai Keiko T Kitazato Yasuhisa Kanematsu Yasushi Takagi Source Type: research
North American multicenter experience with the Flow Redirection Endoluminal Device in the treatment of intracranial aneurysms
CONCLUSIONS: As the first large-scale North American multicenter FRED experience, this study confirmed the ease of successful FRED deployment but suggested lower efficacy and a higher rate of complications than reported by previous European and South American studies on FRED and other flow-diverting devices. The authors recommend judicious use of this device until future studies can better elucidate the long-term outcomes of FRED treatment.PMID:36087324 | DOI:10.3171/2022.7.JNS221371
Source: Journal of Neurosurgery - September 10, 2022 Category: Neurosurgery Authors: MirHojjat Khorasanizadeh Max Shutran Clemens M Schirmer Mohamed M Salem Andrew J Ringer Ramesh Grandhi Alim P Mitha Michael R Levitt Brian T Jankowitz Philipp Taussky Ajith J Thomas Justin M Moore Christopher S Ogilvy Source Type: research
