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Condition: Hemorrhagic Stroke
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Total 12507 results found since Jan 2013.

Primary Results of the Multicenter ARISE II Study (Analysis of Revascularization in Ischemic Stroke With EmboTrap) Major Clinical Trials
Background and Purpose—EmboTrap is a novel stent retriever designed to achieve rapid and substantial flow restoration in acute ischemic stroke secondary to large-vessel occlusions. Here, we evaluated EmboTrap’s safety and efficacy compared with established stent retrievers.Methods—ARISE II (Analysis of Revascularization in Ischemic Stroke With EmboTrap) was a single-arm, prospective, multicenter study, comparing the EmboTrap device to a composite performance goal criterion derived using a Bayesian meta-analysis from the pivotal SWIFT (Solitaire device) and TREVO 2 (Trevo device) trials. Patients at 11 US and 8 Europe...
Source: Stroke - April 23, 2018 Category: Neurology Authors: Osama O. Zaidat, Hormozd Bozorgchami, Marc Ribo, Jeffrey L. Saver, Heinrich P. Mattle, Rene Chapot, Ana Paula Narata, Olivier Francois, Ashutosh P. Jadhav, Jonathan A. Grossberg, Christian H. Riedel, Aleȷandro Tomasello, Wayne M. Clark, Hannes Nord Tags: Ischemia, Revascularization, Cerebrovascular Disease/Stroke, Ischemic Stroke Major Clinical Trial Source Type: research

Early Cerebral Vein After Endovascular Ischemic Stroke Treatment Predicts Symptomatic Reperfusion Hemorrhage Brief Report
Conclusions—ECV on postendovascular mechanical thrombectomy digital subtraction angiography is highly diagnostic of subsequent symptomatic reperfusion hemorrhage in this data set. This finding has important implications for post-treatment management of blood pressure and anticoagulation.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Samuel C.D. Cartmell, Robyn L. Ball, Rajani Kaimal, Nicholas A. Telischak, Michael P. Marks, Huy M. Do, Robert L. Dodd, Gregory W. Albers, Maarten G. Lansberg, Jeremy J. Heit Tags: Cerebrovascular Procedures, Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Induction of Cooling With a Passive Head and Neck Cooling Device: Effects on Brain Temperature After Stroke Clinical Sciences
Conclusions— Although the decrease of brain temperature after Sovika cooling device application was statistically significant, we doubt clinical relevance of this rather limited effect (–0.36°C). Moreover, the transient increases of blood pressure and ICP warrant caution.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Poli, S., Purrucker, J., Priglinger, M., Diedler, J., Sykora, M., Popp, E., Steiner, T., Veltkamp, R., Bosel, J., Rupp, A., Hacke, W., Hametner, C. Tags: Cerebrovascular disease/stroke, CPR and emergency cardiac care, Other Treatment, Emergency treatment of Stroke Clinical Sciences Source Type: research

Continuous Antihypertensive Therapy Throughout the Initial 24 Hours of Intracerebral Hemorrhage: The Stroke Acute Management With Urgent Risk-Factor Assessment and Improvement-Intracerebral Hemorrhage Study Brief Reports
Conclusions— The continuation of AHT throughout the initial 24 hours after ICH may improve outcomes.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Kobayashi, J., Koga, M., Tanaka, E., Okada, Y., Kimura, K., Yamagami, H., Okuda, S., Hasegawa, Y., Shiokawa, Y., Furui, E., Nakagawara, J., Kario, K., Okata, T., Arihiro, S., Sato, S., Nagatsuka, K., Minematsu, K., Toyoda, K., for the SAMURAI Study Invest Tags: Acute Cerebral Hemorrhage, Emergency treatment of Stroke, Other Stroke Treatment - Medical Brief Reports Source Type: research

Evaluation of a Telephone Advice System for Remote Intravenous Thrombolysis in Ischemic Stroke: Data From a United Kingdom Network Brief Reports
Conclusion— Telephone advice and teleradiology, within an organized system of care, can be an effective method of delivery of intravenous thrombolysis.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Dutta, D., Kendall, J., Holmes, C., Murphy, P., Black, T., Whiting, R., Aujla, K., Caine, S., Hellier, K., Walters, D. Tags: Emergency treatment of Stroke, Thrombolysis Brief Reports Source Type: research

Endovascular Treatment for Acute Ischemic Stroke in the Setting of Anticoagulation Brief Reports
Conclusions— Intra-arterial therapy seems to be safe in patients taking OACs; however, our study showed a nonsignificant increase in hemorrhage and mortality with a nonsignificant decrease in good outcomes in comparison with non-OAC patients. Although these nominal differences may have been related to older age and more comorbidities in the OAC group, larger studies are needed to confirm our findings given our limited sample size.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Rebello, L. C., Haussen, D. C., Belagaje, S., Anderson, A., Frankel, M., Nogueira, R. G. Tags: Anticoagulants, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Association Between Serum Phosphate Levels and Stroke Risk in Patients Undergoing Hemodialysis: The Q-Cohort Study Clinical Sciences
Conclusions— Higher serum phosphate levels were associated with an increased risk of brain hemorrhage, whereas low levels were associated with an increased risk of brain infarction in hemodialysis patients. These results suggest the importance of managing serum phosphate levels within an appropriate range in hemodialysis patients. Clinical Trial Registration— URL: http://www.umin.ac.jp/. Unique identifier: UMIN000000556.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Yamada, S., Tsuruya, K., Taniguchi, M., Tokumoto, M., Fujisaki, K., Hirakata, H., Fujimi, S., Kitazono, T. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Intracranial Hemorrhage, Ischemic Stroke Clinical Sciences Source Type: research

Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke) Clinical Sciences
Conclusions—In patients treated with r-tPA, adjunctive argatroban was not associated with increased risk of symptomatic intracerebral hemorrhage and provides evidence that a definitive effectiveness trial is indicated.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique Identifier: NCT01464788.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Andrew D. Barreto, Gary A. Ford, Loren Shen, Claudia Pedroza, Jon Tyson, Chunyan Cai, Mohammad H. Rahbar, James C. Grotta, on behalf of the ARTSS-2 Investigators Tags: Clinical Studies, Cerebrovascular Disease/Stroke, Ischemic Stroke, Thrombosis Original Contributions Source Type: research

Microbleeds, Cerebral Hemorrhage, and Functional Outcome After Stroke Thrombolysis Clinical Sciences
Background and Purpose—We assessed whether the presence, number, and distribution of cerebral microbleeds (CMBs) on pre-intravenous thrombolysis MRI scans of acute ischemic stroke patients are associated with an increased risk of intracerebral hemorrhage (ICH) or poor functional outcome.Methods—We performed an individual patient data meta-analysis, including prospective and retrospective studies of acute ischemic stroke treated with intravenous tissue-type plasminogen activator. Using multilevel mixed-effects logistic regression, we investigated associations of pre-treatment CMB presence, burden (1, 2–4, ≥5, and>10...
Source: Stroke - July 24, 2017 Category: Neurology Authors: Andreas Charidimou, Guillaume Turc, Catherine Oppenheim, Shenqiang Yan, Jan F. Scheitz, Hebun Erdur, Pascal P. Klinger–Gratz, Marwan El–Koussy, Wakoh Takahashi, Yusuke Moriya, Duncan Wilson, Chelsea S. Kidwell, Jeffrey L. Saver, Asma Sallem, S Tags: Magnetic Resonance Imaging (MRI), Prognosis, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Normobaric Hyperoxia Reduces Blood Occludin Fragments in Rats and Patients With Acute Ischemic Stroke Basic Sciences
Conclusions—Blood occludin may be a clinically viable biomarker for evaluating BBB damage during ischemia/reperfusion. NBO therapy has the potential to reduce blood occludin, protect BBB, and improve outcome in AIS patients with intravenous tPA thrombolysis.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02974283.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Shuhai Shi, Zhifeng Qi, Qingfeng Ma, Rong Pan, Graham S. Timmins, Yongmei Zhao, Wenjuan Shi, Yunzhou Zhang, Xunming Ji, Ke Jian Liu Tags: Biomarkers, Clinical Studies, Translational Studies, Blood-Brain Barrier, Ischemic Stroke Original Contributions Source Type: research

Statins and the Risk of Intracerebral Hemorrhage in Patients With Previous Ischemic Stroke or Transient Ischemic Attack Clinical Sciences
Conclusions—Statin use was not associated with an increased risk of ICH among patients with a previous history of IS/TIA.
Source: Stroke - November 27, 2017 Category: Neurology Authors: David Gaist, Larry B. Goldstein, Lucia Cea Soriano, Luis Alberto Garcia Rodriguez Tags: Secondary Prevention, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Diabetes Mellitus, Admission Glucose, and Outcomes After Stroke Thrombolysis: A Registry and Systematic Review Clinical Sciences
Conclusions— These results confirm that AGL and history of diabetes mellitus are associated with poor clinical outcome after thrombolysis. AGL may be a surrogate marker of brain infarction severity rather than a causal factor. However, randomized controlled evidences are needed to address the significance of a tight glucose control during thrombolysis on clinical outcome.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Desilles, J.-P., Meseguer, E., Labreuche, J., Lapergue, B., Sirimarco, G., Gonzalez-Valcarcel, J., Lavallee, P., Cabrejo, L., Guidoux, C., Klein, I., Amarenco, P., Mazighi, M. Tags: Acute Stroke Syndromes, Thrombolysis Clinical Sciences Source Type: research

Younger Stroke Patients With Large Pretreatment Diffusion-Weighted Imaging Lesions May Benefit From Endovascular Treatment Clinical Sciences
Conclusions— There was a growing risk for poor outcome and symptomatic intracerebral hemorrhage with increasing pretreatment DWI lesion volumes. Nevertheless, favorable outcome was achieved in every third patient with DWI lesions >70 mL after successful endovascular reperfusion, whereas after poor or failed reperfusion, outcome was favorable in only every 12th patient. Therefore, endovascular treatment might be considered in patients with large DWI lesions, especially in younger patients.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Gilgen, M. D., Klimek, D., Liesirova, K. T., Meisterernst, J., Klinger-Gratz, P. P., Schroth, G., Mordasini, P., Hsieh, K., Slotboom, J., Heldner, M. R., Broeg-Morvay, A., Mono, M.-L., Fischer, U., Mattle, H. P., Arnold, M., Gralla, J., El-Koussy, M., Jun Tags: Acute Cerebral Infarction, Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Risk Profile of Symptomatic Lacunar Stroke Versus Nonlobar Intracerebral Hemorrhage Brief Reports
Conclusions— The risk factor profile of dICH differs from that associated with LS. This might be used for disease risk stratification at individual level.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Morotti, A., Paciaroni, M., Zini, A., Silvestrelli, G., Del Zotto, E., Caso, V., DellAcqua, M. L., Simone, A. M., Lanari, A., Costa, P., Poli, L., De Giuli, V., Gamba, M., Ciccone, A., Ritelli, M., Di Castelnuovo, A., Iacoviello, L., Colombi, M., Agnelli, Tags: Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Identification of Reversible Disruption of the Human Blood-Brain Barrier Following Acute Ischemia Brief Reports
Conclusions— This study demonstrates that diffuse, mild BBB disruption in the acutely ischemic human brain is reversible with reperfusion. This study also confirms prior findings that focal severe BBB disruption confers an increased risk of hemorrhagic transformation in patients treated with intravenous tissue-type plasminogen activator.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Simpkins, A. N., Dias, C., Leigh, R., on behalf of the National Institutes of Health Natural History of Stroke Investigators, Benson, Hsia, Latour, Luby, Lynch, Merino, Nadareishvili, Warach Tags: Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research