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Tranexamic acid in a mouse model of cerebral amyloid angiopathy: setting the stage for a novel stroke treatment approach
CONCLUSION: Long-term TXA treatment does not alter brain Aβ levels or impact neurologic behavior in mice predisposed to amyloid deposition and had minor effects on the levels of inflammatory mediators. This finding supports the safety of TXA and lays the foundation for TXA as a novel treatment to reduce sICH in patients with CAA.PMID:37694270 | PMC:PMC10483050 | DOI:10.1016/j.rpth.2023.102166
Source: Thrombosis and Haemostasis - September 11, 2023 Category: Hematology Authors: Zikou Liu Fiona M McCutcheon Heidi Ho Joanne Chia Yunxin Xiao Isabel Tippett Charithani B Keragala Geoffrey C Cloud Robert L Medcalf Source Type: research

Incidence and Outcomes of Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Registry-based Descriptive Trial in Kobe City
Neurol Med Chir (Tokyo). 2023 Aug 30. doi: 10.2176/jns-nmc.2023-0090. Online ahead of print.ABSTRACTThe current study aims to evaluate the incidence and results of aneurysmal subarachnoid hemorrhage (aSAH) throughout Kobe City. Based on a multicenter retrospective registry-based descriptive trial involving all 13 primary stroke centers in Kobe City, patients with aSAH treated between October 2017 and September 2019 were studied. A total of 334 patients were included, with an estimated age-adjusted incidence of 11.12 per 100,000 person-years. Curative treatment was given to 94% of patients, with endovascular treatment (51%)...
Source: Neurologia Medico-Chirurgica - August 30, 2023 Category: Neurosurgery Authors: Tsuyoshi Ohta Shirabe Matsumoto Ryu Fukumitsu Hirotoshi Imamura Hidemitsu Adachi Yoshie Hara Kohkichi Hosoda Hidehito Kimura Kazuyuki Kuwayama Takashi Mizowaki Yasuhiko Motooka Shiro Miyata Narihide Shinoda Yasushi Ueno Ikuya Yamaura Yasuhisa Yoshida Chia Source Type: research

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