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Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition
CONCLUSIONS: Together, this study revealed the protection of VPA in ex vivo OGD-induced pathological form of neuroplasticity and in vivo PTI-induced brain damage and motor dysfunction through rescuing GABAergic deficiency and the pathological hallmarks of ischemia.PMID:37695500 | DOI:10.1007/s43440-023-00525-w
Source: Pharmacological Reports - September 11, 2023 Category: Drugs & Pharmacology Authors: Ming-Chia Chu Wei-Chang Mao Han-Fang Wu Yun-Chi Chang Ting-I Lu Chi-Wei Lee Yueh-Jung Chung Tsung-Han Hsieh Hsun-Shuo Chang Yih-Fung Chen Chia-Hsien Lin Chih-Wei Tang Hui-Ching Lin Source Type: research

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease
CONCLUSIONS: There is currently insufficient evidence to determine the effectiveness of ACEi or ARB in patients with stage 1 to 3 CKD who do not have DM. The available evidence is overall of very low certainty and high risk of bias. We have identified an area of large uncertainty for a group of patients who account for most of those diagnosed as having CKD.PMID:37466151 | DOI:10.1002/14651858.CD007751.pub3
Source: Cochrane Database of Systematic Reviews - July 19, 2023 Category: General Medicine Authors: Tess E Cooper Claris Teng David J Tunnicliffe Brydee A Cashmore Giovanni Fm Strippoli Source Type: research

Using Artificial Intelligence in Predicting Ischemic Stroke Events After Percutaneous Coronary Intervention
CONCLUSIONS: The RF model accurately predicts short- and long-term risk of IS and outperforms logistic regression analysis in patients undergoing PCI. Patients with periprocedural stroke may benefit from aggressive management to reduce the future risk of IS.PMID:37410747
Source: The Journal of Invasive Cardiology - July 6, 2023 Category: Cardiology Authors: Chieh-Ju Chao Pradyumna Agasthi Timothy Barry Chia-Chun Chiang Panwen Wang Hasan Ashraf Farouk Mookadam Amith R Seri Nithin Venepally Mohamed Allam Sai Harika Pujari Anil Sriramoju Mohamed Sleem Said Alsidawi Mackram Eleid Nirat Beohar Floyd D Fortuin Eri Source Type: research

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