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Comparing transesophageal Doppler corrected systolic flow time versus central venous pressure as a guide for fluid resuscitation in septic shock
Conclusion Transesophageal aortic Doppler is a simple, non-invasive tool of guiding fluid therapy in patients with severe sepsis and septic shock. FTC change was a better predictor of fluid responsiveness than CVP in septic shock. There was higher significant difference in SV after resuscitation when using FTC as guidance.
Source: Egyptian Journal of Anaesthesia - January 23, 2016 Category: Anesthesiology Source Type: research

Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients.
CONCLUSIONS: Although we have not found conclusive evidence that etomidate increases mortality or healthcare resource utilization in critically ill patients, it does seem to increase the risk of adrenal gland dysfunction and multi-organ system dysfunction by a small amount. The clinical significance of this finding is unknown. This evidence is judged to be of moderate quality, owing mainly to significant attrition bias in some of the smaller studies, and new research may influence the outcomes of our review. The applicability of these data may be limited by the fact that 42% of the patients in our review were intubated for...
Source: Cochrane Database of Systematic Reviews - January 8, 2015 Category: Journals (General) Authors: Bruder EA, Ball IM, Ridi S, Pickett W, Hohl C Tags: Cochrane Database Syst Rev Source Type: research

Improving vital organs perfusion by the respiratory pump: Physiology and clinical use.
CONCLUSION: The clinical and animal studies support the use of the intrathoracic pump to treat different clinical conditions: hemorrhagic shock, orthostatic hypotension, septic shock, and cardiac arrest. PMID: 23932268 [PubMed - as supplied by publisher]
Source: Annales Francaises d'Anesthesie et de Reanimation - August 8, 2013 Category: Anesthesiology Authors: Segal N, Yannopoulos D, Truchot J, Laribi S, Plaisance P, Convertino VA Tags: Ann Fr Anesth Reanim Source Type: research

Effect of acute endotoxemia on analog estimates of mean systemic pressure
Abstract: Dynamic estimates of mean systemic pressure based on a Guytonian analog model (Pmsa) appear accurate under baseline conditions but may not remain so during septic shock because blood volume distribution and resistances between arterial and venous beds may change. Thus, we examined the effect of acute endotoxemia on the ability of Pmsa, estimated from steady-state cardiac output, right atrial pressure, and mean arterial pressure, to reflect our previously validated instantaneous venous return measure of mean systemic pressure (Pmsi), derived from beat-to-beat measures of right ventricular stroke volume and right a...
Source: Journal of Critical Care - June 3, 2013 Category: Intensive Care Authors: Jae Myeong Lee, Olufunmilayo Ogundele, Francis Pike, Michael R. Pinsky Tags: Electronic Articles Source Type: research

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