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Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier
We examined a possible protective effect of OX-A against LPS-induced ROS formation and microglia activation. To mimic in vitro the connection between gut and brain and to study the putative effect on the cortical microglia, we used a co-culture of Caco-2 cells and primary cortical microglia with Caco-2 cells placed at the apical side of a transwell and primary cortical microglia at the basolateral side. All treatments used to study the apical vs. basal connection were applied to the apical compartment. We used DHR (10 μM, 20 min), a cell-permeable fluorogenic probe useful for the detection of ROS formation, to dete...
Source: Frontiers in Endocrinology - April 9, 2019 Category: Endocrinology Source Type: research

Stroke volume change after digoxin loading in septic shock patients with transient left ventricular systolic dysfunction.
In conclusion, in septic shock patients with transient LV dysfunction such as TS, digoxin loading can be a feasible treatment. Further clinical study is needed. Before Digoxin LoadingAfter Digoxin LoadingpEjection Fraction (%)20.2 ± 9.422.2 ± 10.40.327Time-Velocity Integral (cm)10.8 ± 3.112.3 ± 4.60.093LVOT diameter (cm)1.82 ± 0.241.88 ± 0.260.025Stroke Volume (mL)27.6 ± 7.933.7 ± 11.90.048
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lee, D. H., Jeong, J.-H., Kang, B. H., Um, S., Son, C. Tags: Acute Critical Care Source Type: research