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Blood Pressure and Stroke Risk among Diabetic Patients.
Conclusions:The current study suggests a U-shaped association between blood pressure and the risk of stroke. Aggressive BP control (<110/65 mmHg) and high blood pressure (≥160/100 mmHg) are associated with an increased risk of stroke among both African American and white patients with type 2 diabetes. PMID: 23714680 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - May 28, 2013 Category: Endocrinology Authors: Zhao W, Katzmarzyk PT, Horswell R, Wang Y, Johnson J, Cefalu WT, Ryan DH, Hu G Tags: J Clin Endocrinol Metab Source Type: research

Thyroid Function within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis.
CONCLUSION: Higher levels of TSH within the reference range may decrease risk of stroke, highlighting the need for further research focusing on the clinical consequences associated with differences within the reference range of thyroid function. PMID: 27603906 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 6, 2016 Category: Endocrinology Authors: Chaker L, Baumgartner C, den Elzen WP, Collet TH, Ikram MA, Blum MR, Dehghan A, Drechsler C, Luben RN, Portegies ML, Iervasi G, Medici M, Stott DJ, Dullaart RP, Ford I, Bremner A, Newman AB, Wanner C, Sgarbi JA, Dörr M, Longstreth WT, Psaty BM, Ferrucci Tags: J Clin Endocrinol Metab Source Type: research

Regional differences in the prevalence of coronary heart disease and stroke in patients with type 2 diabetes in China.
Conclusions: There were large variations in risks of CHD, stroke and composite of both in T2DM in China with Northeast and North having the highest risks. PMID: 29982638 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - July 3, 2018 Category: Endocrinology Authors: Lyu Y, Luo Y, Li C, Guo X, Lu J, Wu H, Huo X, Gu W, Yang G, Ji L, Yang X Tags: J Clin Endocrinol Metab Source Type: research

Diabetes, myocardial infarction and stroke are distinct and duration-dependent predictors of subsequent cardiovascular events and all-cause mortality in older men.
Conclusions: In older men, increasing duration of diabetes predicts stable increases in all-cause and MI-related mortality and a progressively higher risk of stroke deaths. Prior MI was associated with increased risk of subsequent MI, and prior stroke with subsequent stroke, particularly in the 10-20 years following the first event. Diabetes is a duration-dependent risk factor for cardiovascular events which influences outcomes differently from prior vascular disease. PMID: 25548977 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 30, 2014 Category: Endocrinology Authors: Yeap BB, McCaul KA, Flicker L, Hankey GJ, Almeida OP, Golledge J, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

SGLT2 inhibitors: Effect on myocardial infarction and stroke in type 2 diabetes
J Clin Endocrinol Metab. 2023 Feb 28:dgad113. doi: 10.1210/clinem/dgad113. Online ahead of print.ABSTRACTBACKGROUND: SGLT2 inhibitors (sodium-glucose cotransporter-2 inhibitors) have recently been recommended as preferred agents for management of hyperglycemia in type 2 diabetes, primarily based on their ability to reduce a composite of major cardiovascular adverse events (3P MACE), predominantly by reducing cardiovascular death. However reduction of the individual components, myocardial infarction (MI) or stroke (fatal and non-fatal) events have not been well explored.METHODS: In this meta-analysis, we included data avail...
Source: The Journal of Clinical Endocrinology and Metabolism - March 1, 2023 Category: Endocrinology Authors: Pradip Mukhopadhyay Debmalya Sanyal Purushottam Chatterjee Kaushik Pandit Sujoy Ghosh Source Type: research

Ezetimibe-Simvastatin Therapy Reduce Recurrent Ischemic Stroke Risks in Type 2 Diabetic Patients.
CONCLUSIONS: High potency lipid-lowering therapy effectively reduces the risk of recurrent IS in diabetic patients regardless of ATOR or EZ-SIM combination therapy. PMID: 27270238 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 5, 2016 Category: Endocrinology Authors: Liu CH, Chen TH, Lin MS, Hung MJ, Chung CM, Cherng WJ, Lee TH, Lin YS Tags: J Clin Endocrinol Metab Source Type: research

The Relationship between Glucose Control & Cognitive Function in People with Diabetes after a Lacunar Stroke.
CONCLUSION: This analysis of lacunar stroke patients with diabetes demonstrates a relationship between A1C and change in cognitive scores over time. Intervention studies are needed in order to delineate if better glucose control could slow the rate of cognitive decline in this high risk population. PMID: 33481011 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - January 22, 2021 Category: Endocrinology Authors: Cukierman-Yaffe T, McClure LA, Thomas R, Bosch J, Sharma M, Gerstein HC, Benavente O Tags: J Clin Endocrinol Metab Source Type: research

Proportion of undercarboxylated osteocalcin and serum P1NP predict incidence of myocardial infarction in older men.
CONCLUSIONS: Areduced proportion of undercarboxylated osteocalcin or higherP1NPare associated with increased incidence of MI. UcOC/TOC ratio and P1NP predict risk of MI but not stroke, in a manner distinct from CTX. Further studies are needed to investigate potential mechanisms by which bone turnover markers related to metabolic risk and to collagen formation could modulate cardiovascular risk. PMID: 26308289 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 26, 2015 Category: Endocrinology Authors: Yeap BB, Alfonso H, Chubb SA, Byrnes E, Beilby JP, Ebeling PR, Allan CA, Schultz C, Hankey GJ, Golledge J, Flicker L, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study
CONCLUSION: We identified alanine as a new amino acid associated with increased risk of CAD and glutamine as a new amino acid associated with decreased risk of ischemic stroke. We also confirmed that phenylalanine and tyrosine were associated with CAD, ischemic stroke, and CVD events.PMID:34346487 | DOI:10.1210/clinem/dgab562
Source: The Journal of Clinical Endocrinology and Metabolism - August 4, 2021 Category: Endocrinology Authors: Raimo Jauhiainen Jagadish Vangipurapu Annamaria Laakso Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Source Type: research

GLP-1 Receptor Agonists and Risk of Adverse Cerebrovascular Outcomes in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
CONCLUSION: GLP-1RAs, precisely longer acting formulations, reduced ischemic cerebrovascular events in T2DM. Observed benefits were significantly higher in patients with shorter T2DM duration and higher eGFR.PMID:36800286 | DOI:10.1210/clinem/dgad076
Source: The Journal of Clinical Endocrinology and Metabolism - February 17, 2023 Category: Endocrinology Authors: Mainak Banerjee Rimesh Pal Satinath Mukhopadhyay Kirthana Nair Source Type: research

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