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E-132 Successful mechanical thrombectomy in an 11-year-old patient with emergent large vessel occlusion acute ischemic stroke related to congenital complete heart block and recent covid-19 infection
ConclusionsThis is a first known report of a successful mechanical thrombectomy in a pediatric patient due to a large vessel occlusion related to congenital complete heart block and recent COVID-19 infection.Disclosures J. Ansari: None. D. Mata Canadas: None. M. Ayub: None. J. Caskey: None. P. Simoncini: None. R. Riel-Romero: None. P. Sharma: None. D. Jordan: None. H. Cuellar: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ansari, J., Mata Canadas, D., Ayub, M., Caskey, J., Simoncini, P., Riel-Romero, R., Sharma, P., Jordan, D., Cuellar, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Peg tube insertion in neurodegenerative disease
Conclusion This study highlights the relatively high risk of PEG tube placement in patients with neurodegenerative disease. We present a number of points for consideration with the aim of improving the outcome in this particularly vulnerable group of patients.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Sarkar, P., Cole, A., Scolding, N., Rice, C. Tags: Dementia, Drugs: CNS (not psychiatric), Stroke, Memory disorders (psychiatry) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

MRI in amyotrophic lateral sclerosis: more than a promise
In amyotrophic lateral sclerosis, the deadliest form of motor neuron diseases, physicians observe the spread of non-painful paralysis with intact sensory function often presenting as asymmetric muscle atrophy and brisk or maintained reflexes. Using Awaji criteria to estimate upper and lower motor neuron signs in bulbar, cervical, thoracic and lumbar regions, and the highly sensitive electromyography (EMG), they diagnose amyotrophic lateral sclerosis (ALS) in a majority of the cases. The spread of symptoms is attributed to spinal motor neuron pathology, but experienced ALS neurologists will agree that a slowing of movement,...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 9, 2013 Category: Neurosurgery Authors: Grosskreutz, J. Tags: Dementia, Drugs: CNS (not psychiatric), Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke, Memory disorders (psychiatry), Psychiatry of old age Editorial commentaries Source Type: research

Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis
Conclusions Cerebrovascular injury from a variety of causes, rather than the presence of AVM or the associated embolisation procedure per se, may be a risk factor for ALS within the context of a more complex multiple-hit model of pathogenesis.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2016 Category: Neurosurgery Authors: Turner, M. R., Goldacre, R., Talbot, K., Goldacre, M. J. Tags: Open access, Genetics, Drugs: CNS (not psychiatric), Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke Neurodegeneration Source Type: research

New therapeutic option for drop foot with the ActiGait peroneal nerve stimulator – A technical note
Publication date: Available online 9 July 2015 Source:World Neurosurgery Author(s): K. Daniel Martin , Witold Polanski , Gabriele Schackert , Stephan B. Sobottka A drop foot occurs in up to 20% of stroke patients and leads to an increased risk of falls. Until recently, only a foot orthosis or surface stimulation were able to improve the gait of these patients. Recent studies have shown that direct peroneal nerve stimulation with an implantable four-channel peroneal nerve stimulator (ActiGait) allows independent electrode adjustment and leads to better functional results and an improved quality of life. The application of...
Source: World Neurosurgery - July 10, 2015 Category: Neurosurgery Source Type: research

Neurological complication related to atrial myxomas
Conclusions This case highlights both the recognised neurologic complications of atrial myxoma in a single patient and presents the characteristic angiographic findings. The diagnosis of cerebral aneurysms can be delayed up to five years1. Evaluation should therefore be considered following a histologic diagnosis of atrial myxoma.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: Baird-Gunning, J., Lalloo, S., Lueck, C. J., Das, C. Tags: Abstracts Source Type: research

Longitudinal research into alzheimer's disease, fronto-temporal dementia and other dementias
Conclusion The BNSU provides an easy method of referral of patients with dementia for their inclusion in research.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Rossor, M., Ahmed, R., Liang, Y., Douglas, J., Mahoney, C., Warren, J., Schott, J., Fox, N. Tags: Dementia, Drugs: CNS (not psychiatric), Motor neurone disease, Neuroimaging, Neuromuscular disease, Stroke, Memory disorders (psychiatry), Psychiatry of old age Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians Source Type: research

The 17 syndrome
A 58-year-old man woke from uneventful right cerebellopontine angle surgery (grade I schwannoma resection) with severe, lower motor neurone (LMN) facial diplegia and near-complete nuclear horizontal ophthalmoplegia, uncorrectable by vestibulo-ocular reflex. Vertical gaze and convergence were normal. Examination was otherwise normal, excepting right sensorineural anacusis (a short HD video will be shown). CT brain revealed expected post-operative changes. MRI wasn't possible due to a pacemaker, inserted for symptomatic bradyarrhythmias. There has been no improvement after 12 months. We attribute this presentation to infarct...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Evans, M. R., Weeks, R. Tags: Abstracts Source Type: research

A fine neuroscience vintage
I recently bumped into a cardiologist mate who had just won a silver medal for his first wild barrel ferment Chardonnay from the vineyard he started with a haematologist, their wine label aptly named Blood Brothers. He told me his approach to cultivating a fine harvest. While many factors play a role he said, the raw product and how it is nurtured, remains the key. The grape variety and how it responds to the prevailing climate at the time of harvest are the critical factors in producing a fine wine vintage. After our conversation, I was impelled to draw a parallel between his wine making and the process of extracting prac...
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 17, 2014 Category: Neurosurgery Authors: Kiernan, M. C. Tags: Genetics, Long term care, Immunology (including allergy), Dementia, Epilepsy and seizures, Motor neurone disease, Movement disorders (other than Parkinsons), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Spinal cord, Stroke, Memory Source Type: research

Female gender doubles executive dysfunction risk in ALS: a case-control study in 165 patients
Conclusions Results highlight a significant vulnerability of ALS female patients to develop cognitive dysfunctions peculiar to the disease, independently of bulbar onset. The explicative hypotheses of the data are focused on two interpretative lines not mutually exclusive: the role of gonadal hormones and gender-related brain asymmetry pre-existing to the disease. These findings, never reported before in the literature, can have important implications for models of ALS pathogenesis and for future clinical trial designs.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 13, 2015 Category: Neurosurgery Authors: Palmieri, A., Mento, G., Calvo, V., Querin, G., D'Ascenzo, C., Volpato, C., Kleinbub, J. R., Bisiacchi, P. S., Soraru, G. Tags: Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke, Memory disorders (psychiatry) Cognitive neurology Source Type: research

The frontotemporal dementias: a neuropsychiatric perspective
Professor John Hodges MD, FRCP, FRACP, F Med Sci John is Professor of Cognitive Neurology at the University of New South Wales based at the Neuroscience Research Australia where he co-directs the Frontotemporal Dementia Research Group (FRONTIER www.ftdrg.org). John qualified in Medicine from London University with honours (1975) and undertook periods of psychiatric and neurological raining in Southampton, Oxford and San Diego and obtained his MD in 1988. From 1997 to 2007 he was the MRC Professor of Behavioural Neurology with a joint appointments in the Department of Clinical Neuroscience at Addenbrooke's Hospital and the ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 13, 2015 Category: Neurosurgery Tags: Dementia, Drugs: CNS (not psychiatric), Motor neurone disease, Neuroimaging, Neuromuscular disease, Parkinson's disease, Stroke, Memory disorders (psychiatry), Psychiatry of old age, Psychotic disorders (incl schizophrenia) PRESENTATION ABSTRACTS - DAY Source Type: research

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk
Conclusions Rather than structural brain changes, increased FC may be among the earliest detectable brain abnormalities in asymptomatic carriers of ALS-causing gene mutations. With replication and significant refinement, this technique has potential in the future assessment of neuroprotective strategies.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 12, 2016 Category: Neurosurgery Authors: Menke, R. A. L., Proudfoot, M., Wuu, J., Andersen, P. M., Talbot, K., Benatar, M., Turner, M. R. Tags: Open access, Genetics, Brain stem / cerebellum, Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke, Radiology, Radiology (diagnostics) Neurodegeneration Source Type: research

Pseudo spastic gait can reveal a Stiff Leg Syndrome (SLS)
Spastic gait is classically link to a corticospinal syndrome related to upper motor neuron involvement from various causes (stroke, multiple sclerosis, cerebral tumor, motor neuron disorders…). Focal dystonia is another cause of limb stiffness. Several conditions resulting in abnormal movements, postures, or spasm that may resemble spastic gait or focal dystonia have been recognized (including disorders of the central and peripheral nervous systems as well as non-neurological conditions).
Source: Clinical Neurology and Neurosurgery - June 11, 2016 Category: Neurosurgery Authors: Coline Duwicquet, Julien Biberon, Bertrand de Toffol, Philippe Corcia Tags: Case Report Source Type: research

Natural history and the dawning of a new era for familial ALS
To date, more than 20 different genes have been discovered linked to the development of amyotrophic lateral sclerosis (ALS), with C9ORF72, TARDBP, SOD1 and FUS being the most prevalent.1 Since the discovery of the SOD1 mutation in 1993—the first gene associated with the disease—models based on this genetic mutation have made a significant contribution to understanding ALS pathogenesis. So far, more than 180 SOD1 mutations have been described, further contributing to ALS heterogeneity through expression as different clinical phenotypes. However, despite these advances in genetic understanding, ALS remains a univ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 12, 2017 Category: Neurosurgery Authors: Matamala, J. M., Kiernan, M. C. Tags: Genetics, Immunology (including allergy), Drugs: CNS (not psychiatric), Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke Editorial commentaries Source Type: research

079 Unmasking of motor neuron disease by botulinum toxin therapy
A 75 year-old male with a history of a right hemiparesis due to past h/o stroke sustained a T3 vertebral body compression fracture after a fall and was treated conservatively. Six months later, in a rehabilita- tion clinic he reported that following discharge there had been a gradual deterioration in his mobility and strength, particularly on the right side. His right upper limb had become more stiff and painful with decreased range of movements. Two months later he received Dysport injections to the right elbow flexors, right brachioradialis, soleus and right flexor carpi radialis. Four days later, he developed worsening ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Paluri, S., Hassan, M., Lambert, T. Tags: Poster Presentations Source Type: research