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Transient brain hypothermia reduces the reperfusion injury of delayed tissue plasminogen activator and extends its therapeutic time window in a focal embolic stroke model.
We examined whether short-term and mild local brain cooling can prevent hyperemia and/or adverse effects of delayed tPA in rat embolic stroke model. Male animals were subjected to embolic stroke and then randomly classified into control (saline), tPA (1mg/kg; i.v.), local hypothermia (LH), and tPA+LH. The drug was injected at 6h after ischemia. LH was conducted by direct ipsilateral (injured) hemisphere cooling at 6.5h after stroke and maintained for approximately 30minutes. Cerebral blood flow was monitored in a duration of 60minute after tPA administration and hyperemic response was measured. Infarct volume, blood-brain ...
Source: Brain Research Bulletin - July 11, 2017 Category: Neurology Authors: Zarisfi M, Allahtavakoli F, Hassanipour M, Khaksari M, Rezazadeh H, Allahtavakoli M, Taghavi MM Tags: Brain Res Bull Source Type: research