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Lidocaine response rate in aEEG‐confirmed neonatal seizures: Retrospective study of 413 full‐term and preterm infants
Summary ObjectiveTo investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second‐ or third‐line antiepileptic drug (AED) for neonatal seizures. MethodsFull‐term (n = 319) and preterm (n = 94) infants, who received lidocaine for neonatal seizures confirmed on amplitude‐integrated EEG (aEEG), were studied retrospectively (January 1992–December 2012). Based on aEEG findings, the response was defined as good (>4 h no seizures, no need for rescue medication); intermediate (0–2 h no seizures, but rescue medication needed after 2–4 h); or no clear response (resc...
Source: Epilepsia - December 31, 2015 Category: Neurology Authors: Lauren C. Weeke, Mona C. Toet, Linda G. M. Rooij, Floris Groenendaal, Geraldine B. Boylan, Ronit M. Pressler, Lena Hellström‐Westas, Marcel P. H. Broek, Linda S. Vries Tags: Full ‐Length Original Research Source Type: research

Neuroprotection After Major Cardiovascular Surgery
Opinion statement Neurologic injury is a common complication of major cardiovascular procedures including coronary artery bypass graft (CABG) surgery, coronary valve replacement, and aortic aneurysm surgery. However, despite ongoing research in the field of neuroprotection, there are currently few pharmacologic and interventional options to effectively protect the brain and spinal cord in the postoperative period. CSF drainage after aortic surgery currently stands as the only neuroprotective intervention that has been consistently shown to protect the spinal cord from ischemic injury, leading to significantly few...
Source: Current Treatment Options in Neurology - May 15, 2015 Category: Neurology Source Type: research