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Condition: Heart Disease
Drug: Aspirin

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Total 179 results found since Jan 2013.

Aspirin For Primary Prevention Of Heart Attacks In Men: Eligibility Increases When Cancer Mortality Benefit Added
While aspirin has been shown to be effective in preventing heart attacks in men, it also increases the risk of gastrointestinal bleeding and possibly stroke, even at low doses. As such, national guidelines suggest that aspirin be used for prevention only in men at higher risk for cardiovascular events, so that the benefits of aspirin are greater than its adverse effects. Recent data suggest that aspirin may also be effective for reducing cancer deaths...
Source: Health News from Medical News Today - June 10, 2013 Category: Consumer Health News Tags: Heart Disease Source Type: news

The Timing Hypothesis and Hormone Replacement Therapy: A Paradigm Shift in the Primary Prevention of Coronary Heart Disease in Women. Part 2: Comparative Risks
A major misperception concerning postmenopausal hormone replacement therapy (HRT) is that the associated risks are large in magnitude and unique to HRT, but over the past 10 years, sufficient data have accumulated so that the magnitude and perspective of risks associated with the primary coronary heart disease prevention therapies of statins, aspirin, and postmenopausal HRT have become more fully defined. Review of randomized controlled trials indicates that the risks of primary prevention therapies and other medications commonly used in women's health are of similar type and magnitude, with the majority of these risks ca...
Source: Journal of the American Geriatrics Society - May 20, 2013 Category: Geriatrics Authors: Howard N. Hodis, Wendy J. Mack Tags: Updates on Aging Source Type: research

Use of antiplatelet drugs in stroke prevention: time for a rethink?
Worldwide, 15 million people suffer stroke each year from which a third die and a further third sustain severe disability, with ischaemic events accounting for ~80% of all strokes.1 The annual estimated economic burden of stroke is 64.1 billion in Europe alone.2 While recent major investments in acute stroke services have focused on thrombolysis and hospitalisation in dedicated stroke wards, we believe that primary and secondary stroke prevention should remain of utmost importance in a disease that carries such serious permanent neurological sequelae. Antiplatelet agents such as aspirin, diypridamole or clodpidogrel are ph...
Source: Postgraduate Medical Journal - May 17, 2013 Category: Journals (General) Authors: Loke, Y. K., White, J. R., Bettencourt-Silva, J. H., Potter, J. F., Myint, P. K. Tags: GI bleeding, Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Epidemiology Editorials Source Type: research

Abstract 231: Under Utilization of Aspirin for Primary Prevention Poster Session II
Conclusion: Aspirin is being under-utilized as part of primary prevention strategy. The presence of diabetes and an elderly patient often prompts a recommendation for aspirin use. A conscious effort should be made by hospital based care providers to ensure that the appropriate preventive strategies are part of their discharge medication list.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Gopalakrishnan, M., Silva-Palacios, F., Villines, D., Klein, L. Tags: Poster Session II Source Type: research

Lack of association between proton pump inhibitors and adverse events in patients taking clopidogrel and aspirin
Commentary on Douglas IJ, Evans SJ, Hingorani AD, et al.. Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs. BMJ 2012;345:e4388 Context Clopidogrel inhibits the P2Y12 platelet receptor and is used in patients with acute coronary syndromes or ischaemic stroke to prevent recurrent vascular events. Proton pump inhibitors (PPIs), however, have been shown to reduce the pharmacodynamic effect of clopidogrel upon platelet inhibition, and have been linked in retrospective studies to a higher rate of ischaemic outcomes in patients taking clopidogrel. Methods A total o...
Source: Evidence-Based Medicine - May 15, 2013 Category: Internal Medicine Authors: Waksman, R., Gaglia, M. A. Tags: Smoking and tobacco, Epidemiologic studies, Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Health education, Smoking Aetiology Source Type: research

Aspirin therapy
Periodontitis involves inflammation caused by complex interactions between plaque microorganisms and the host immune system. An imbalance in the host response causes local tissue destruction, so the ability to modulate host response pathways may help to treat periodontal disease. Aspirin exerts anti-inflammatory effects by inhibiting prostanoid synthesis. Prostaglandin-E2 (PGE2) is an important prostanoid product that participates in the pathogenesis of destructive periodontal disease. Aspirin has a powerful inhibitor effect on cyclo-oxygenase metabolites such as PGE2. Low-dose aspirin is taken by many middle-aged and elde...
Source: Dental Abstracts - May 1, 2013 Category: Dentistry Tags: Periodontal Disease Source Type: research

Who Is Taking Aspirin To Prevent Heart Attack Or Stroke? First Of Its Kind Study In Canada
A new study out of the Faculty of Medicine & Dentistry shows a large population of healthy people are taking Aspirin to prevent cardiovascular disease, despite the fact that new literature shows it isn't as beneficial as once thought. Olga Szafran and Mike Kolber, in the Department of Family Medicine at the University of Alberta, surveyed patients over the age of 50 at two clinics in Alberta. They found that more than 40 per cent of people who don't suffer from cardiovascular disease are popping pills daily to prevent a heart attack or stroke - a practice called primary prevention...
Source: Health News from Medical News Today - March 21, 2013 Category: Consumer Health News Tags: Heart Disease Source Type: news

Aspirin prophylaxis in people without prior cardiovascular disease does not lead to reductions in cardiovascular death or cancer mortality
Commentary on: Seshasai SR, Wijesuriya S, Sivakumaran R, et al.. Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials. Arch Intern Med 2012;172:209–16. Context Prophylactic antiplatelet therapy with aspirin reduces the risk of non-fatal myocardial infarction (MI), non-fatal stroke and vascular death in patients with known cardiovascular disease (CVD) and is of net benefit. The absolute reduction in recurrent events significantly exceeds the increase in major bleeding.1 However, the role of aspirin in primary prevention of CVD is not clear. According to the Antithrombot...
Source: Evidence-Based Medicine - March 19, 2013 Category: Internal Medicine Authors: Farooq, M. U., Gorelick, P. B. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Prevention, Ischaemic heart disease Online articles Source Type: research

Thromboprophylaxis in heart failure patients with sinus rhythm: aspirin and warfarin lead to similar cardiovascular outcomes
Commentary on: Homma S, Thompson JL, Pullicino PM, et al.. WARCEF Investigators. Warfarin and aspirin in patients with heart failure and sinus rhythm. N Engl J Med 2012;366:1859–69. Context Chronic heart failure (CHF) is common, affecting 1–2% of the population and 10% of people >70 years. Patients with CHF have an increased risk of thromboembolism. Those with atrial fibrillation (AF) should receive warfarin but whether CHF patients with sinus rhythm (SR), whose risk is 1.5–3.5%,1 should receive thromboprophylaxis is unclear. Previous studies, Warfarin/Aspirin Study in Heart failure (warfarin, asp...
Source: Evidence-Based Medicine - March 19, 2013 Category: Internal Medicine Authors: Witte, K. K. A., Jamil, H. A. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Diabetes, Arrhythmias Therapeutics Source Type: research

Aspirin Linked To Blinding Eye Disease
WebMD Medical News By Brenda Goodman, MA Reviewed by Laura J. Martin, MD Jan. 22, 2013 — Regular aspirin users are more likely to develop the “wet” form of age-related macular degeneration compared to people who rarely or never take the drug, a new study shows. Aspirin is one of the most widely used drugs in the world. Millions of people with heart disease take a daily low dose of aspirin in hopes of preventing heart attacks and stroke. It’s also used to ease pain. Macular degeneration is a leading cause of blindness in older adults, and it is on the rise. The “wet” form accounts for on...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 23, 2013 Category: Consumer Health News Authors: mreal197 Tags: WebMD News Source Type: news

Long-term aspirin use 'increases blindness risk'
Conclusion This cohort study has suggested that there may be a link between aspirin use and risk of developing wet AMD. The main strengths of this study are that it followed people up over a long time, collected data prospectively and carried out thorough eye examinations for AMD. This means that cases of AMD were not likely to be missed. However, it should be noted that: The study’s main weakness was that, as a cohort study, its results may be affected by confounding, although the researchers did try to take into account factors that could be having an effect. Confounding ‘by indication’ is a possibility; this is...
Source: NHS News Feed - January 22, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Medication Source Type: news

Impact of Proton Pump Inhibitor Therapy on the Efficacy of Clopidogrel in the CAPRIE and CREDO Trials Coronary Heart Disease
Conclusions In CREDO, the efficacy of clopidogrel was not significantly affected by PPI use. However, in CAPRIE, clopidogrel was beneficial to non-PPI users while apparently harmful to PPI users. Whether this negative interaction is clinically important for patients receiving clopidogrel without aspirin needs further study.
Source: JAHA:Journal of the American Heart Association - January 15, 2013 Category: Cardiology Authors: Dunn, S. P., Steinhubl, S. R., Bauer, D., Charnigo, R. J., Berger, P. B., Topol, E. J. Tags: Coronary Heart Disease Source Type: research

Health maintenance in women.
Abstract The health maintenance examination is an opportunity to focus on disease prevention and health promotion. The patient history should include screening for tobacco use, alcohol misuse, intimate partner violence, and depression. Premenopausal women should receive preconception counseling and contraception as needed, and all women planning or capable of pregnancy should take 400 to 800 mcg of folic acid per day. High-risk sexually active women should be counseled on reducing the risk of sexually transmitted infections, and screened for chlamydia, gonorrhea, and syphilis. All women should be screened for huma...
Source: American Family Physician - January 1, 2013 Category: Primary Care Authors: Riley M, Dobson M, Jones E, Kirst N Tags: Am Fam Physician Source Type: research

Peripheral artery disease and outcomes after myocardial infarction: An individual-patient meta-analysis of 28,771 patients in CAPRICORN, EPEHESUS, OPTIMAAL and VALIANT
Abstract: Objectives: To examine the prevalence of peripheral artery disease (PAD) and the relationship between PAD and cardiovascular (CV) outcomes in subjects with left ventricular systolic dysfunction, heart failure or both after acute myocardial infarction (MI).Background: PAD is associated with poorer prognosis in patients with stable and unstable coronary heart disease but whether PAD is associated with worse outcomes following substantial acute MI is unknown.Methods: Univariate and multivariate Cox proportional hazards modelling was used to compare clinical outcomes in an individual-patient meta-analysis of 4 trials...
Source: International Journal of Cardiology - November 29, 2012 Category: Cardiology Authors: Sally C. Inglis, Judith Bebchuk, Sultan A. Al-Suhaim, Jessica Case, Marc A. Pfeffer, Scott D. Solomon, Yingxin (Rachel) Hou, Bertram Pitt, Henry J. Dargie, Ian Ford, John Kjekshus, Faiez Zannad, Kenneth Dickstein, John J.V. McMurray Tags: Original Articles Source Type: research