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'Moderate global aphasia': A generalized decline of language processing caused by glioma surgery but not stroke
Brain Lang. 2021 Dec 6;224:105057. doi: 10.1016/j.bandl.2021.105057. Online ahead of print.ABSTRACTUnlike stroke, neurosurgical removal of left-hemisphere gliomas acts upon a reorganized language network and involves brain areas rarely damaged by stroke. We addressed whether this causes the profiles of neurosurgery- and stroke-induced language impairments to be distinct. K-means clustering of language assessment data (neurosurgery cohort: N = 88, stroke cohort: N = 95) identified similar profiles in both cohorts. But critically, a cluster of individuals with specific phonological deficits was only evident in the stroke but...
Source: Brain and Language - December 9, 2021 Category: Neurology Authors: Andrey Zyryanov Ekaterina Stupina Elizaveta Gordeyeva Olga Buivolova Evdokiia Novozhilova Yulia Akinina Oleg Bronov Natalia Gronskaya Galina Gunenko Ekaterina Iskra Elena Ivanova Anton Kalinovskiy Evgenii Kliuev Dmitry Kopachev Elena Kremneva Oksana Kryuc Source Type: research

Abnormally weak functional connections get stronger in chronic stroke patients who benefit from naming therapy
We examined functional connectivity in a 38-region picture-naming network in 30 patients with chronic aphasia who did or did not receive naming therapy. Compared to healthy controls, patients had abnormally low connectivity in a subset of connections from the naming network. Linear mixed models showed that the connectivity of abnormal connections increased significantly in patients who benefited from therapy, but not in those who did not benefit from or receive therapy. Changes in responders were specific to abnormal connections and did not extend to the larger network. Thus, successful naming therapy was associated with i...
Source: Brain and Language - October 25, 2021 Category: Neurology Authors: Jeffrey P Johnson Erin L Meier Yue Pan Swathi Kiran Source Type: research

Neural bases of elements of syntax during speech production in patients with aphasia
Brain Lang. 2021 Sep 20;222:105025. doi: 10.1016/j.bandl.2021.105025. Online ahead of print.ABSTRACTThe ability to string together words into a structured arrangement capable of conveying nuanced information is key to speech production. The assessment of the neural bases for structuring sentences has been challenged by the need of experts to delineate the aberrant morphosyntactic structures in aphasic speech. Most studies have relied on focused tasks with limited ecological validity. We characterized syntactic complexity during connected speech produced by patients with chronic post-stroke aphasia. We automated this proces...
Source: Brain and Language - September 23, 2021 Category: Neurology Authors: Ezequiel Gleichgerrcht Rebecca Roth Julius Fridriksson Dirk den Ouden John Delgaizo Brielle Stark Gregory Hickok Chris Rorden Janina Wilmskoetter Argye Hillis Leonardo Bonilha Source Type: research

Behavioral and neurological effects of tDCS on speech motor recovery: A single-subject intervention study.
This report supports the possibility that tDCS may enhance both behavioral and neurological outcomes and indicates the importance of additional work in this area, although replication is required to confirm the extent and consistency of tDCS benefits on speech motor learning treatment outcomes. PMID: 32905863 [PubMed - as supplied by publisher]
Source: Brain and Language - September 5, 2020 Category: Neurology Authors: Buchwald A, Khosa N, Rimikis S, Duncan ES Tags: Brain Lang Source Type: research

Pre-treatment graph measures of a functional semantic network are associated with naming therapy outcomes in chronic aphasia.
In this study, 26 patients with chronic aphasia completed a semantic judgment fMRI task before receiving up to 12 weeks of naming treatment. Global (i.e., network-wide) and local (i.e., regional) graph theoretic measures of pre-treatment functional connectivity were analyzed to identify differences between patients who responded most and least favorably to treatment (i.e., responders and nonresponders) and determine if network measures predicted naming improvements. Responders had higher levels of global integration (i.e., average network strength and global efficiency) than nonresponders, and these measures predicted tre...
Source: Brain and Language - June 3, 2020 Category: Neurology Authors: Johnson JP, Meier EL, Pan Y, Kiran S Tags: Brain Lang Source Type: research

Effects of prosody on the cognitive and neural resources supporting sentence comprehension: A behavioral and lesion-symptom mapping study.
Abstract Non-canonical sentence comprehension impairments are well-documented in aphasia. Studies of neurotypical controls indicate that prosody can aid comprehension by facilitating attention towards critical pitch inflections and phrase boundaries. However, no studies have examined how prosody may engage specific cognitive and neural resources during non-canonical sentence comprehension in persons with left hemisphere damage. Experiment 1 examines the relationship between comprehension of non-canonical sentences spoken with typical and atypical prosody and several cognitive measures in 25 persons with chronic le...
Source: Brain and Language - February 3, 2020 Category: Neurology Authors: LaCroix AN, Blumenstein N, Tully M, Baxter LC, Rogalsky C Tags: Brain Lang Source Type: research

Continuous theta burst stimulation over right pars triangularis facilitates naming abilities in chronic post-stroke aphasia by enhancing phonological access.
CONCLUSION: CTBS of the rPTr enhances naming by facilitating phonological access during word retrieval, indicating that individuals whose naming impairment is localized to this stage of processing may be most likely to benefit from this rTMS approach. PMID: 30870740 [PubMed - as supplied by publisher]
Source: Brain and Language - March 10, 2019 Category: Neurology Authors: Harvey DY, Mass JA, Shah-Basak PP, Wurzman R, Faseyitan O, Sacchetti DL, DeLoretta L, Hamilton RH Tags: Brain Lang Source Type: research

Repetitive verbal behaviors are not always harmful signs: Compensatory plasticity within the language network in aphasia.
Abstract Repetitive verbal behaviors such as conduite d'approche (CdA) and mitigated echolalia (ME) are well-known phenomena since early descriptions of aphasia. Nevertheless, there is no substantial fresh knowledge on their clinical features, neural correlates and treatment interventions. In the present study we take advantage of three index cases of chronic fluent aphasia showing CdA, ME or both symptoms to dissect their clinical and neural signatures. Using multimodal neuroimaging (structural magnetic resonance imaging and [18]-fluorodeoxyglucose positron emission tomography during resting state), we found that...
Source: Brain and Language - January 18, 2019 Category: Neurology Authors: Torres-Prioris MJ, López-Barroso D, Roé-Vellvé N, Paredes-Pacheco J, Dávila G, Berthier ML Tags: Brain Lang Source Type: research

Critical brain regions related to post-stroke aphasia severity identified by early diffusion imaging are not the same when predicting short- and long-term outcome.
CONCLUSION: Routine clinical images can be merged with atlases of anatomical connectivity to provide new insights about the relationship between the lesion location and aphasia severity. PMID: 30179751 [PubMed - as supplied by publisher]
Source: Brain and Language - September 1, 2018 Category: Neurology Authors: Zavanone C, Samson Y, Arbizu C, Dupont S, Dormont D, Rosso C Tags: Brain Lang Source Type: research

Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study.
Abstract Research has shown that linguistic functions in the bilingual brain are subserved by similar neural circuits as in monolinguals, but with extra-activity associated with cognitive and attentional control. Although a role for the right cerebellum in multilingual language processing has recently been acknowledged, a potential role of the left cerebellum remains largely unexplored. This paper reports the clinical and fMRI findings in a strongly right-handed (late) multilingual patient who developed differential polyglot aphasia, ataxic dysarthria and a selective decrease in executive function due to an ischem...
Source: Brain and Language - September 13, 2017 Category: Neurology Authors: Mariën P, van Dun K, Van Dormael J, Vandenborre D, Keulen S, Manto M, Verhoeven J, Abutalebi J Tags: Brain Lang Source Type: research

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