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Total 6126 results found since Jan 2013.

Elevated Levels of Hemoglobin A1c Are Associated With Cerebral White Matter Disease in Patients With Stroke Clinical Sciences
Conclusions— Among known risk factors, higher levels of HbA1c were associated with cerebral WMD in stroke patients. This may suggest that chronic disturbance of glycemia measured by HbA1c plays a role in the pathophysiology of WMD. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00715533.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Rozanski, M., Richter, T. B., Grittner, U., Endres, M., Fiebach, J. B., Jungehulsing, G. J. Tags: Cerebrovascular disease/stroke, Glucose intolerance, CT and MRI Clinical Sciences Source Type: research

Age- and gender-specific prevalence of risk factors in patients with first-ever ischemic stroke in china.
Conclusion. Our study showed that vascular risk factors had a specific age and gender distribution pattern in Chinese IS patients. Secondary prevention strategy should emphasize on the control of different risk factors based on patient's age and gender. PMID: 22762013 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Alteplase for Acute Ischemic Stroke: Outcomes by Clinically Important Subgroups in the Third International Stroke Trial Clinical Sciences
Conclusions— Among the types of patient in the Third International Stroke Trial, this secondary analysis did not identify any subgroups for whom treatment should be avoided. Given the limitations of the analysis, we found no clear evidence to avoid treatment in patients with prior ischemic stroke, diabetes mellitus, or hypertension. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN25765518. http://www.controlled-trials.com/ISRCTN25765518.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Lindley, R. I., Wardlaw, J. M., Whiteley, W. N., Cohen, G., Blackwell, L., Murray, G. D., Sandercock, P. A. G., on behalf of the IST-3 Collaborative Group, Trial Steering Committee, Baigent, Chadwick, Tyrrell, Lowe, Dennis, Innes, Goodare, CT and MR readi Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Patients With Ischemic Stroke and Incident Atrial Fibrillation: A Nationwide Cohort Study Clinical Sciences
Conclusions— Ischemic stroke was associated with a substantially increased risk of incident AF, particularly among individuals with higher CHADS2 or CHA2DS2-VASc scores. These risk scores seem to be simple tools for identifying patients at higher risk of incident AF after ischemic stroke.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Fauchier, L., Clementy, N., Pelade, C., Collignon, C., Nicolle, E., Lip, G. Y. H. Tags: Arrhythmias, clinical electrophysiology, drugs, Embolic stroke Clinical Sciences Source Type: research

Perceived Unmet Rehabilitation Needs 1 Year After Stroke: An Observational Study From the Swedish Stroke Register Brief Reports
Conclusions— Unfulfilled rehabilitation needs 1 year poststroke are common and associated with high age, dependency, pain, and depression. Long-term follow-up systems should, therefore, be comprehensive and address multiple domains of poststroke problems, rather than having a single-domain focus.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Ullberg, T., Zia, E., Petersson, J., Norrving, B. Tags: Quality and Outcomes, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Heart Rate Variability and Incident Stroke: The Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— Lower HRV was associated with higher risk of incident stroke among middle-aged adults with prevalent diabetes mellitus but not among people without diabetes mellitus.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Fyfe-Johnson, A. L., Muller, C. J., Alonso, A., Folsom, A. R., Gottesman, R. F., Rosamond, W. D., Whitsel, E. A., Agarwal, S. K., MacLehose, R. F. Tags: Autonomic Nervous System, Cardiovascular Disease, Diabetes, Type 2, Risk Factors, Ischemic Stroke Clinical Sciences Source Type: research

Reducing Readmissions After Stroke With a Structured Nurse Practitioner/Registered Nurse Transitional Stroke Program Clinical Sciences
Conclusions— Evaluation in a nurse practitioner–led structured clinic is a model that may reduce readmissions at 30 days for stroke patients discharged home.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Condon, C., Lycan, S., Duncan, P., Bushnell, C. Tags: Cost-Effectiveness, Health Services, Quality and Outcomes, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Ethnic Comparison of Clinical Characteristics and Ischemic Stroke Subtypes Among Young Adult Patients With Stroke in Hawaii Clinical Sciences
Background and Purpose—Native Hawaiians and other Pacific Islanders (NHOPI) with ischemic stroke have younger age of stroke onset compared with whites. However, ethnic differences in stroke subtypes in this population have been inadequately studied.Methods—Consecutive young adult patients (aged ≤55 years) who were hospitalized for ischemic stroke between 2006 and 2012 at a tertiary center in Honolulu were studied. Clinical characteristics and stroke subtypes based on pathophysiological TOAST classification (Trial of Org 10172) of NHOPI and Asians were compared with whites.Results—A total of 427 consecutive young ad...
Source: Stroke - December 22, 2016 Category: Neurology Authors: Kazuma Nakagawa, Cherisse S. Ito, Sage L. King Tags: Race and Ethnicity, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Prevalence of Fabry Disease and Outcomes in Young Canadian Patients With Cryptogenic Ischemic Cerebrovascular Events Clinical Sciences
Conclusions—In this Canadian cohort of patients with cryptogenic IS or TIA, the prevalence of Fabry was 0.3% if p.R118C variant is considered as pathogenic. This suggests that more cost-effective methods should be applied for diagnosis of Fabry rather than systematic genetic screening in this population. Overall, cryptogenic IS in young adults is associated with favorable outcomes.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Sylvain Lanthier, Gustavo Saposnik, Gerald Lebovic, Karen Pope, Daniel Selchen, David F. Moore, on behalf of the Canadian Fabry Stroke Screening Initiative Study Group Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA), Vascular Disease Original Contributions Source Type: research

Clinical and Demographic Characteristics Associated With Suboptimal Primary Stroke and Transient Ischemic Attack Prevention Clinical Sciences
Conclusions—Knowing the patient characteristics predictive of missed opportunities for stroke prevention may help primary care identify and appropriately manage these patients. Improving the management of these groups may reduce their risk and potentially prevent large number of future strokes and TIAs in the population.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Grace M. Turner, Melanie Calvert, Max G. Feltham, Ronan Ryan, Samuel Finnikin, Tom Marshall Tags: Epidemiology, Primary Prevention, Hypertension, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Lifestyle Risk Factors for Ischemic Stroke and Transient Ischemic Attack in Young Adults in the Stroke in Young Fabry Patients Study Original Contributions
Conclusions— In this large European cohort of young patients with acute ischemic cerebrovascular events, modifiable risk factors were highly prevalent, particularly in men and older patients. These data emphasize the need for vigorous primary and secondary prevention measures already in young populations targeting modifiable lifestyle vascular risk factors. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique Identifier: NCT00414583.
Source: Stroke - December 24, 2012 Category: Neurology Authors: von Sarnowski, B., Putaala, J., Grittner, U., Gaertner, B., Schminke, U., Curtze, S., Huber, R., Tanislav, C., Lichy, C., Demarin, V., Basic-Kes, V., Ringelstein, E. B., Neumann-Haefelin, T., Enzinger, C., Fazekas, F., Rothwell, P. M., Dichgans, M., Junge Tags: Risk Factors, Acute Cerebral Infarction, Primary and Secondary Stroke Prevention, Risk Factors for Stroke Original Contributions Source Type: research

Effect of High-Dose Atorvastatin on Renal Function in Subjects With Stroke or Transient Ischemic Attack in the SPARCL Trial Clinical Sciences
Conclusions— This post hoc analysis suggests that atorvastatin treatment may improve renal function in patients with prior stroke or transient ischemic attack with and without chronic kidney disease, and that atorvastatin treatment may prevent eGFR decline in patients with stroke and diabetes mellitus. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00147602.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Amarenco, P., Callahan, A., Campese, V. M., Goldstein, L. B., Hennerici, M. G., Messig, M., Sillesen, H., Welch, K. M. A., Wilson, D. J., Zivin, J. A. Tags: Lipids, Secondary prevention, Cerebrovascular disease/stroke Clinical Sciences Source Type: research

Neurorestorative Responses to Delayed Human Mesenchymal Stromal Cells Treatment of Stroke in Type 2 Diabetic Rats Basic Sciences
Conclusions—In T2DM stroke rats, delayed hMSC treatment significantly improves neurological functional outcome and increases neurorestorative effects and M2 macrophage polarization. Increasing brain platelet-derived growth factor expression may contribute to hMSC-induced neurorestoration.
Source: Stroke - October 23, 2016 Category: Neurology Authors: Yan, T., Venkat, P., Chopp, M., Zacharek, A., Ning, R., Roberts, C., Zhang, Y., Lu, M., Chen, J. Tags: Cell Therapy, Stem Cells, Diabetes, Type 2, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke Clinical Sciences
Conclusions—In this magnetic resonance imaging–verified lacunar stroke population, we identified a distinct risk factor profile in the group as a whole. However, there were differing risk factor profiles according to the presence of multiple lacunar infarcts and confluent WMH. The association of hypertension, smoking, and renal impairment with the presence of multiple lacunar infarcts and confluent WMH might reflect a diffuse small vessel arteriopathy.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Hugh S. Markus Tags: Risk Factors, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Impact of Stroke Risk Factors on Ethnic Stroke Disparities Among Midlife Mexican Americans and Non-Hispanic Whites Brief Report
Conclusions—The higher prevalence of diabetes mellitus and hypertension and stronger association of diabetes mellitus with IS among midlife Mexican Americans likely contribute to persistent midlife ethnic stroke disparities.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Raȷiv C. Patel, Brisa N. Sanchez, Lewis B. Morgenstern, Chengwei Li, Lynda D. Lisabeth Tags: Race and Ethnicity, Risk Factors, Ischemic Stroke Brief Reports Source Type: research