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Impact of hypertension on mortality and cardiovascular disease burden in patients with cardiovascular risk factors from a general practice setting: the ESCARVAL-risk study
Conclusion: Our results highlight the relevance of hypertension as main risk factor for mortality and cardiovascular events in a real-life setting. Although our data support the ongoing need of cardiovascular risk factors prevention, intensified actions for primary prevention of hypertension show potential to largely reduce the burden of cardiovascular disease.
Source: Journal of Hypertension - April 29, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

The impact of patients' involvement in cooking on their mortality and morbidity: A 19-year follow-up of patients diagnosed with type 2 diabetes mellitus.
Conclusions. In patients newly diagnosed with T2DM and with a regular intake of warm main meals, infrequent involvement in cooking was associated with an increased risk of diabetes-related death and stroke for women, but not for men. General practitioners should pay special attention to managing diabetes treatment in female patients newly diagnosed with T2DM who report infrequent involvement in cooking. PMID: 25592166 [PubMed - as supplied by publisher]
Source: Primary Care - January 16, 2015 Category: Primary Care Authors: Jandorf S, Siersma V, Køster-Rasmussen R, Olivarius NF, Waldorff FB Tags: Scand J Prim Health Care Source Type: research

Clinical prediction rules in practice: review of clinical guidelines and survey of GPs.
CONCLUSION: GPs use CPRs to guide management but also to comply with local policy requirements. Future research could focus on which clinical areas clinicians would most benefit from CPRs and promoting the use of robust, externally validated CPRs. PMID: 24686888 [PubMed - in process]
Source: The British Journal of General Practice - April 1, 2014 Category: Primary Care Authors: Plüddemann A, Wallace E, Bankhead C, Keogh C, Van der Windt D, Lasserson D, Galvin R, Moschetti I, Kearley K, O'Brien K, Sanders S, Mallett S, Malanda U, Thompson M, Fahey T, Stevens R Tags: Br J Gen Pract Source Type: research

Stroke.
Abstract In 2012, about 50 000 Australians had a stroke (cerebrovascular accident (CVA)). The risk of stroke is associated with increased age, previous stroke or transient ischaemic attack, hypertension, smoking, diabetes mellitus (DM), hypercholesterolaemia and atrial fibrillation/flutter (AF). Australian general practice data from the national BEACH program between April 2000 and March 2013 inclusive (1 276 200 GP-patient encounters) were analysed to determine the patient characteristics, associated conditions and management options at those encounters where a CVA was recorded, and detect changes in the annual m...
Source: Australian Family Physician - March 1, 2014 Category: Primary Care Authors: Pollack A, Harrison C, Henderson J, Miller G Tags: Aust Fam Physician Source Type: research

Adjusting for measurement error in baseline prognostic biomarkers included in a time-to-event analysis: a joint modelling approach
Conclusion: The joint modelling of longitudinal and survival data is a valid approach to account for measurement error in the analysis of a repeatedly measured biomarker and a time-to-event. User friendly Stata software is provided.
Source: BMC Medical Research Methodology - Latest articles - December 1, 2013 Category: Research Authors: Michael CrowtherPaul LambertKeith Abrams Source Type: research

High salt levels in soluble drugs may raise heart risk
Conclusion This large case control study suggested that people who had experienced disease of the heart and blood vessels were more likely to have taken sodium-containing medicines than people without cardiovascular disease. Put in other words this can be interpreted that people who took sodium-containing medicines were at a higher risk of experiencing cardiovascular disease than people who took the same medications in formulations free of sodium. The increased risk appeared to be driven mostly by an increased risk of hypertension and to a lesser extent, non-fatal stroke. The study has some strengths including its large s...
Source: NHS News Feed - November 27, 2013 Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news

Characteristics and Future Cardiovascular Risk of Patients With Not‐At‐Goal Hypertension in General Practice in France: The AVANT'AGE Study
Although many studies focus on patients with resistant hypertension, general practitioners (GPs) are more likely to face patients in clinical practice with not‐at‐goal hypertension, whose antihypertensive treatment needs to be modified. However, information regarding such patients is limited. In the present study, 710 GPs in France each included their first 10 not‐at‐goal hypertensive patients, ie, the patients for whom they decided to modify antihypertensive treatment. The study population was composed of 7032 patients (58% men, mean age 62.4±11.5 years). Anthropometric and biologic measurements and clinical dat...
Source: The Journal of Clinical Hypertension - March 7, 2013 Category: Cardiology Authors: Yi Zhang, Hélène Lelong, Sandrine Kretz, Davide Agnoletti, Jean‐Jacques Mourad, Michel E. Safar, Jacques Blacher Tags: Original Paper Source Type: research

Mortality and Other Important Diabetes-Related Outcomes With Insulin vs Other Antihyperglycemic Therapies in Type 2 Diabetes.
Conclusions: In people with T2DM, exogenous insulin therapy was associated with an increased risk of diabetes-related complications, cancer, and all-cause mortality. Differences in baseline characteristics between treatment groups should be considered when interpreting these results. PMID: 23372169 [PubMed - in process]
Source: The Journal of Clinical Endocrinology and Metabolism - February 1, 2013 Category: Endocrinology Authors: Currie CJ, Poole CD, Evans M, Peters JR, Morgan CL Tags: J Clin Endocrinol Metab Source Type: research

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