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GLP-1 Receptor Agonists and Risk of Adverse Cerebrovascular Outcomes in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
CONCLUSION: GLP-1RAs, precisely longer acting formulations, reduced ischemic cerebrovascular events in T2DM. Observed benefits were significantly higher in patients with shorter T2DM duration and higher eGFR.PMID:36800286 | DOI:10.1210/clinem/dgad076
Source: The Journal of Clinical Endocrinology and Metabolism - February 17, 2023 Category: Endocrinology Authors: Mainak Banerjee Rimesh Pal Satinath Mukhopadhyay Kirthana Nair Source Type: research

C-reactive protein and racial differences in type 2 diabetes incidence: The REGARDS study
CONCLUSIONS: Higher CRP is a risk factor for incident diabetes, but the excess burden of diabetes in Black adults was only seen in those with lower CRP, suggesting that inflammation is unlikely to be the main driver of this racial disparity.PMID:35137178 | DOI:10.1210/clinem/dgac074
Source: The Journal of Clinical Endocrinology and Metabolism - February 9, 2022 Category: Endocrinology Authors: Kaitlyn M Peper Boyi Guo D Leann Long George Howard April P Carson Virginia J Howard Suzanne E Judd Neil A Zakai Andrea Cherrington Mary Cushman Timothy B Plante Source Type: research

Association between Obesity and Cardiovascular Disease in Elderly Patients with Diabetes: A Retrospective Cohort Study
CONCLUSION: Our study with elderly patients with diabetes results suggest that while BMI is an inadequate risk indicator for outcomes related to obesity, WC is a suitable alternative.PMID:34597374 | DOI:10.1210/clinem/dgab714
Source: The Journal of Clinical Endocrinology and Metabolism - October 1, 2021 Category: Endocrinology Authors: Sangmo Hong Jung Hwan Park Kyungdo Han Chang Beom Lee Dong Sun Kim Sung Hoon Yu Source Type: research

Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort
CONCLUSIONS: Pro-NT/NMN was associated with MetS and two components, dysglycemia and low HDL, likely explained by insulin resistance.PMID:34013344 | DOI:10.1210/clinem/dgab355
Source: The Journal of Clinical Endocrinology and Metabolism - May 20, 2021 Category: Endocrinology Authors: Charles D Nicoli April P Carson Timothy B Plante D Leann Long Leslie A McClure Janin Schulte Mary Cushman Source Type: research

Pioglitazone for the primary and secondary prevention of cardiovascular and renal outcomes in patients with or at high risk of type 2 diabetes mellitus: a meta-analysis.
CONCLUSIONS: Pioglitazone should be considered in patients with or at high risk of T2DM for the prevention of cardiovascular endpoints, especially in those with a history of established CVD who might benefit the most. Robust reductions in progression of renal disease are seen regardless of baseline renal function degree. PMID: 31822895 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 10, 2019 Category: Endocrinology Authors: Zhou Y, Huang Y, Ji X, Wang X, Shen L, Wang Y Tags: J Clin Endocrinol Metab Source Type: research

Regional differences in the prevalence of coronary heart disease and stroke in patients with type 2 diabetes in China.
Conclusions: There were large variations in risks of CHD, stroke and composite of both in T2DM in China with Northeast and North having the highest risks. PMID: 29982638 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - July 3, 2018 Category: Endocrinology Authors: Lyu Y, Luo Y, Li C, Guo X, Lu J, Wu H, Huo X, Gu W, Yang G, Ji L, Yang X Tags: J Clin Endocrinol Metab Source Type: research

Relative risks of contributing factors to morbidity and mortality in adults with craniopharyngioma on GH replacement.
Conclusion: Conventional factors that increase the risks of cardio/cerebrovascular diseases and DM, and risks for developing new intra-cranial tumors contribute to the excess morbidity and mortality. Additionally, lower serum IGF-I levels measured from the last sample before death was inversely associated with mortality risk in CP patients. PMID: 29029108 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 29, 2017 Category: Endocrinology Authors: Yuen KCJ, Mattsson AF, Burman P, Erfurth EM, Camacho-Hubner C, Fox JL, Verhelst J, Geffner ME, Abs R Tags: J Clin Endocrinol Metab Source Type: research

Ezetimibe-Simvastatin Therapy Reduce Recurrent Ischemic Stroke Risks in Type 2 Diabetic Patients.
CONCLUSIONS: High potency lipid-lowering therapy effectively reduces the risk of recurrent IS in diabetic patients regardless of ATOR or EZ-SIM combination therapy. PMID: 27270238 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 5, 2016 Category: Endocrinology Authors: Liu CH, Chen TH, Lin MS, Hung MJ, Chung CM, Cherng WJ, Lee TH, Lin YS Tags: J Clin Endocrinol Metab Source Type: research

Factors Associated with Cardiovascular Events in Patients with Type 2 Diabetes and Acute Myocardial Infarction.
CONCLUSIONS: Postprandial glycemia should be considered a potential target in trials to reduce CV morbidity and mortality in type 2 diabetes mellitus. PMID: 26595100 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - November 23, 2015 Category: Endocrinology Authors: Strojek K, Raz I, Jermendy G, Gitt AK, Liu R, Zhang Q, Jacober SJ, Milicevic Z Tags: J Clin Endocrinol Metab Source Type: research

Diabetes, myocardial infarction and stroke are distinct and duration-dependent predictors of subsequent cardiovascular events and all-cause mortality in older men.
Conclusions: In older men, increasing duration of diabetes predicts stable increases in all-cause and MI-related mortality and a progressively higher risk of stroke deaths. Prior MI was associated with increased risk of subsequent MI, and prior stroke with subsequent stroke, particularly in the 10-20 years following the first event. Diabetes is a duration-dependent risk factor for cardiovascular events which influences outcomes differently from prior vascular disease. PMID: 25548977 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 30, 2014 Category: Endocrinology Authors: Yeap BB, McCaul KA, Flicker L, Hankey GJ, Almeida OP, Golledge J, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

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