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Roche and Alnylam report positive topline results from Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi therapeutic in development to treat hypertension in patients at high risk of cardiovascular disease
Zilebesiran met primary endpoint demonstrating greater than 15 mmHg reduction of systolic blood pressure at three months of treatment compared to placeboStudy met key secondary endpoints showing consistent and sustained reductions of systolic blood pressure at six monthsZilebesiran demonstrated an encouraging safety and tolerability profile in adult patients with mild-to-moderate hypertensionFull study results to be presented at an upcoming scientific conferenceBasel, 7 September 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Alnylam announced today that the Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi the...
Source: Roche Media News - September 7, 2023 Category: Pharmaceuticals Source Type: news

Roche enters partnership with Alnylam to co-develop and co-commercialise RNAi therapeutic zilebesiran to treat hypertension in patients with high cardiovascular risk
Partnership combines Roche ’s proven track record of successfully developing and launching innovative medicines worldwide withAlnylam ’s leadership in RNAi therapeuticsZilebesiran, a Phase 2 RNAi therapeutic, has best-in-disease potential for patients with hypertension at high risk of cardiovascular morbidity and mortality, by robustly and durably lowering blood pressureHypertension, the leading cause of cardiovascular disease, affects more than 1.2 billion adults worldwide. While several therapies exist, a significant unmet need, especially for high risk patients, remains.1Basel, 24 July 2023 - Roche (SIX: RO, ROG; OT...
Source: Roche Media News - July 24, 2023 Category: Pharmaceuticals Source Type: news

Informing Patients with Acute Stroke About their Risk of Dementia: A Survey of UK Healthcare Professionals
People who have a stroke are at an increased risk of developing dementia.1,2 According to the 2021 James Lind Alliance –Stroke Association Priority Setting Partnership, cognitive issues after stroke are a key concern of people who have a stroke.3 Identifying which patients with acute stroke are at risk of dementia could help patients and their carers to plan for the future. However, informing a patient who has jus t had a stroke about their risk of dementia may cause anxiety.
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2022 Category: Neurology Authors: Emily L. Ball, Gillian E. Mead, Eugene Y.H. Tang, Dorota Religa, Terence J. Quinn, Susan D. Shenkin Source Type: research

Food as Prevention – Rising to Nutritional Challenges
Mothers and their children gather at a community nutrition centre in the little village of Rantolava, Madagascar, to learn more about a healthy diet. Credit: Alain Rakotondravony/IPSBy Gabriele RiccardiNAPLES, Italy, Nov 25 2020 (IPS) The risks factors contributing to the dramatic rise in non-communicable diseases (NCDs) in recent decades have been known for a long time but the Covid-19 pandemic has brutally exposed our collective failure to deal with them. Reporting on the findings of the latest Global Burden of Disease Study, The Lancet warns of a “perfect storm” created by the interaction of the highly infectious C...
Source: IPS Inter Press Service - Health - November 25, 2020 Category: International Medicine & Public Health Authors: Gabriele Riccardi Tags: Development & Aid Economy & Trade Featured Food Security and Nutrition Food Sustainability Global Headlines Health Humanitarian Emergencies Inequity Poverty & SDGs TerraViva United Nations Barilla Center for Food and Nutrition Foun Source Type: news

Cells to Society: "Gold Standard" Chicago Parent Program / Research News
This study was conducted to enhance the rate of advance care planning conversations and documentation by improving knowledge, attitudes, and skills of caregivers.      Read more   Violence and Trauma ...
Source: Johns Hopkins University and Health Systems Archive - October 18, 2019 Category: Nursing Source Type: news

Study: Drinking Diet Soda Could Increase Risk Of Dementia, Stroke
BOSTON (CBS) – Diet soda has long been touted as a healthier alternative to sugary soft drinks, but a new study raises some concerning questions. According to new research published in the American Heart Association’s journal Stroke, consuming one or more artificially sweetened drinks per day may be linked to a higher risk of stroke and dementia. Those who drank one or more artificially sweetened drinks daily had a 2.89 times higher risk of dementia, and 2.96 higher risk of stroke than people who had less than one of those drinks per week. The people studied are participating in the Framingham Heart Study, which is A...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 21, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Uncategorized Diet Soda Study Source Type: news

006 pp: collaboration in museums and health research
This study reflects on the range of collaborations in two distinct but thematically linked UCL research projects which consider the role of culture in health promotion: Museums on Prescription (2014–2017), in partnership with Canterbury Christ Church University, explores the value of heritage encounters in social prescribing for lonely older adults at risk of social isolation; and Not So Grim Up North (2016–2018), in conjunction with Whitworth Art Gallery, University of Manchester and Tyne & Wear Archives & Museums, investigates the health and wellbeing impacts of museum activities for stroke survivors;...
Source: BMJ Open - March 3, 2017 Category: Journals (General) Authors: Morse, N., Lockyer, B., Camic, P., Thomson, L., Chatterjee, H. Tags: Open access Culture, Creativity and Innovation in Qualitative Research Source Type: research

Tau Imaging Among Breakthroughs Advancing the Fight against Alzheimer ' s
Worldwide,  nearly44 million  people now have Alzheimer ' s disease (AD) or related dementia, making these conditions the  top cause of disabilities in later life. The biopharma industry has invested billions of dollars into research to treat and prevent AD1, yet this work has faced many obstacles, including difficulty identifying biomarkers, tracking the disease ’s progress in the brain, and recruiting patients to trials while they are still asymptomatic. But in recent years, we’ve begun to see breakthroughs that is driving our research in new directions. Many of these accomplishments were highlighted at the Alzh...
Source: EyeForPharma - September 21, 2016 Category: Pharmaceuticals Authors: Olga Uspenskaya-Cadoz Source Type: news

An Integrated Approach for Vascular Health: A Call to Action
Publication date: Available online 6 November 2014 Source:Canadian Journal of Cardiology Author(s): Blair J. O'Neill , Shadab N. Rana , Vincent Bowman Vascular diseases such as stroke, myocardial infarction, most causes of heart failure, dementia, peripheral arterial disease, certain kidney, and many lung and eye conditions are a result of disorders in the blood vessels (large and small) throughout the entire human body. Vascular diseases are the leading cause of preventable death and disability in Canada 1 . Most vascular diseases share common risk factors (high blood pressure, diabetes, dyslipidemia and obesity), which...
Source: Canadian Journal of Cardiology - November 7, 2014 Category: Cardiology Source Type: research