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Source: Frontiers in Neurology
Condition: Dementia
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Total 55 results found since Jan 2013.
The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
Glutamate is the brain’s main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptors, AMPA receptors are the predominant mediator of glutamate-induced excitatory neurotransmission and dictate synaptic efficiency and plasticity by their numbers and/or properties. Therefore, they appear to be a major drug target for modulating several brain functions. Perampanel (PER) is a highly selective, noncompetitive AMPA...
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research
Prediction of long-term mortality in patients with ischemic stroke based on clinical characteristics on the first day of ICU admission: An easy-to-use nomogram
ConclusionThis proposed nomogram has good performance in predicting long-term mortality among ischemic stroke patients.
Source: Frontiers in Neurology - April 14, 2023 Category: Neurology Source Type: research
Echocardiographic correlates of MRI imaging markers of cerebral small-vessel disease in patients with atrial-fibrillation-related ischemic stroke
ConclusionIn patients with AF-related ischemic stroke, LVPW is associated with a higher risk of lacunes and CSVD burden, while RAD was associated with greater CSO-EPVS. Larger studies are required to determine these associations and to elucidate if these associations can help facilitate cognitive evaluation and brain MRI screening.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
Cerebral small-vessel disease at high altitude: A comparison of patients from plateau and plain
ConclusionPatients of CSVD residing at high altitude showed more severe WMH but less acute cerebrovascular events and lacunes in neuroimaging, comparing to patients residing at low altitude. Our findings suggest potential biphasic effect of high altitude on the occurrence and progression of CSVD.
Source: Frontiers in Neurology - March 9, 2023 Category: Neurology Source Type: research
Bioinformatic identification of potential biomarkers and therapeutic targets in carotid atherosclerosis and vascular dementia
BackgroundVascular disease is the second most common cause of dementia. The prevalence of vascular dementia (VaD) has increased over the past decade. However, there are no licensed treatments for this disease. Carotid atherosclerosis (CAS) is highly prevalent and is the main cause of ischemic stroke and VaD. We studied co-expressed genes to understand the relationships between CAS and VaD and further reveal the potential biomarkers and therapeutic targets of CAS and VaD.MethodsCAS and VaD differentially expressed genes (DEGs) were identified through bioinformatic analysis Gene Expression Omnibus (GEO) datasets GSE43292 and...
Source: Frontiers in Neurology - January 10, 2023 Category: Neurology Source Type: research
Normal left atrial diameter is associated with better performance on a cognitive screener among a cohort of ischemic stroke patients
ConclusionsIn this prospective study, among ischemic stroke patients with a LAD within the normal range, a 1 mm increase in LAD was associated with higher scores on a telephone cognitive battery, without an association found among those with a LAD >4 cm.
Source: Frontiers in Neurology - November 24, 2022 Category: Neurology Source Type: research
Self-reported cognitive and psychiatric symptoms at 3 months predict single-item measures of fatigue and daytime sleep 12 months after ischemic stroke
ConclusionSelf-reported cognitive and psychiatric symptoms at 3 months predict increased daytime sleep and fatigue at 12 months. This highlights the relevance of monitoring cognitive and psychiatric symptoms in the subacute phase post-stroke. However, future research using validated measures of self-reported symptoms are needed to further explore these relationships.
Source: Frontiers in Neurology - November 17, 2022 Category: Neurology Source Type: research
Rhythmic auditory cueing in atypical parkinsonism: A pilot study
Rhythmic auditory cueing (RAC) can improve gait parameters in neurological disorders such as Parkinson's disease and stroke. However, there is a lack of research on the effects of RAC in patients with atypical parkinsonian disorders (APD). Using a smartphone metronome application, we aimed to investigate the immediate effects of RAC in patients with clinically diagnosed APD, namely Progressive Supranuclear Palsy (PSP-Richardson Syndrome and other variants, PSP-nonRS), Corticobasal Syndrome (CBS), Multiple System Atrophy (MSA), and Dementia with Lewy Bodies (DLB). A total of 46 APD participants (25 PSP, 9 CBS, 8 MSA and 4 D...
Source: Frontiers in Neurology - October 28, 2022 Category: Neurology Source Type: research
Corrigendum: Blood pressure control and risk of post-stroke dementia among the elderly: A population-based screening study
Source: Frontiers in Neurology - October 28, 2022 Category: Neurology Source Type: research
Effects of dual-task training in patients with post-stroke cognitive impairment: A randomized controlled trial
ConclusionCMDT training in patients with PSCI improved global cognitive function, which was supported by the improved neural efficiency of associated brain areas.Clinical trial registrationhttp://www.chictr.org.cn, identifier ChiCTR2000034862.
Source: Frontiers in Neurology - October 24, 2022 Category: Neurology Source Type: research
Cognitive recovery in patients with post-stroke subjective cognitive complaints
ConclusionsAlthough post-stroke SCC contributes to persisting objective cognitive deficits, some patients presented cognitive recovery within 1 year after stroke. Patients with a high education level reporting SCC at earlier stage after stroke had poorer cognitive recovery. Male, higher baseline MoCA scores, coffee intake and thalamus lesions appear to independently predict cognitive recovery.
Source: Frontiers in Neurology - September 27, 2022 Category: Neurology Source Type: research
Bibliometric review of 1992 –2022 publications on acupuncture for cognitive impairment
ConclusionThis research provides valuable information for the study of acupuncture. Diseases focus on mild cognitive impairment (MCI), Alzheimer's disease (AD), and vascular dementia (VaD). Tauopathies with hyperphosphorylation of Tau protein as the main lesions also need to be paid attention to. The development of functional magnetic resonance imaging (fMRI) will better explain the therapeutic effect of acupuncture treatment. The effect of acupuncture on a single point is more convincing, and acupuncture on Baihui (GV20) may be needed in the future. Finally, the implementation of high-quality multicenter randomized contro...
Source: Frontiers in Neurology - September 26, 2022 Category: Neurology Source Type: research
Late-onset seizures and epilepsy: Electroclinical features suggestive of autoimmune etiology
ConclusionOur study shows that high-frequency focal seizures with autonomic manifestations should raise the suspicion of AE in the elderly with new-onset seizures. It also highlights the relevant contribution of AEEG, which might reduce the diagnostic delay and provide useful clues to recognize AE.
Source: Frontiers in Neurology - August 12, 2022 Category: Neurology Source Type: research
Blood pressure control and risk of post-stroke dementia among the elderly: A population-based screening study
ConclusionsThe crude prevalence of PSD among stroke survivors aged ≥65 years was 17.8% at community level. In addition to lower education level and older age, poorly-controlled blood pressure was also an independent risk factor for PSD among the elderly, which is amenable to intervention. Therefore, it is essential to control blood pressure to reduce PSD incidence.
Source: Frontiers in Neurology - August 9, 2022 Category: Neurology Source Type: research
Covert vascular brain injury in chronic kidney disease
This article summarizes the currently available clinical evidence linking covert vascular brain injuries with CKD.
Source: Frontiers in Neurology - July 25, 2022 Category: Neurology Source Type: research
