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Cardiovascular events and risk in patients with systemic lupus erythematosus: Systematic literature review and meta-analysis
CONCLUSIONS: This meta-analysis found an increased risk of stroke, MI, CVD, and hypertension in patients with SLE compared with the general population, despite substantial heterogeneity across the included studies.PMID:36547368 | DOI:10.1177/09612033221147471
Source: Lupus - December 22, 2022 Category: Rheumatology Authors: Natalia Bello Kristin J Meyers Jennifer Workman Louise Hartley Maureen McMahon Source Type: research

Antiphospholipid syndrome-mediated acute cerebrovascular diseases and long-term outcomes
CONCLUSION: We found no differences between stroke subtypes and APS types. aPL profiles were not associated with any of the acute cerebrovascular diseases described in this cohort. CVT may be an initial thrombotic manifestation of APS with low mortality and good long-term functional outcome.PMID:35042376 | DOI:10.1177/09612033221074178
Source: Lupus - January 19, 2022 Category: Rheumatology Authors: Miguel Garc ía-Grimshaw Diego Rub én Posadas-Pinto Amado Jim énez-Ruiz Sergio Iv án Valdés-Ferrer Arturo Cadena-Fern ández Jos é Jiram Torres-Ruiz Jos é Domingo Barrientos-Guerra Margarita Amancha-Gabela Erwin Chiquete Fernando Daniel Flores-Silva Source Type: research

Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis
CONCLUSION: A weighted GRS for SLE was associated with an increased risk of several autoimmune-related phenotypes including type I diabetes but not with cardiometabolic disorders.PMID:33977795 | DOI:10.1177/09612033211014952
Source: Lupus - May 12, 2021 Category: Rheumatology Authors: Vivian K Kawai Mingjian Shi Ge Liu QiPing Feng WeiQi Wei Cecilia P Chung Theresa L Walunas Adam S Gordon James G Linneman Scott J Hebbring John B Harley Nancy J Cox Dan M Roden C Michael Stein Jonathan D Mosley Source Type: research

Autoantibodies to Annexin A2 and cerebral thrombosis: Insights from a mouse model.
CONCLUSIONS: This study supports the hypothesis that auto-antibodies to ANXA2 are an independent risk factor for cerebral thrombosis. Consequently, we propose screening for anti-ANXA2 antibodies should be more widely used and patients that exhibit the manifestations of APS should be closely monitored by physicians. PMID: 33554716 [PubMed - as supplied by publisher]
Source: Lupus - February 7, 2021 Category: Rheumatology Authors: Weiss R, Bushi D, Mindel E, Bitton A, Diesendruck Y, Gera O, Drori T, Zmira O, Aharoni SA, Agmon-Levin N, Kashi O, Benhar I, Golderman V, Orion D, Chapman J, Shavit-Stein E Tags: Lupus Source Type: research