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Biomarkers associated with bleeding risk in the setting of atrial fibrillation.
Conclusions Biomarkers were introduced in clinical practice in order to better estimate the potential risk of haemorrhage in these patients and increase the prognostic impact of clinical risk scores. In the last years this concept is gaining significant importance. PMID: 28721832 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - July 18, 2017 Category: Chemistry Authors: Sideris S, Archontakis S, Latsios G, Lazaros G, Toutouzas K, Tsiamis E, Vavuranakis M, Vlachopoulos C, Gatzoulis K, Tsioufis K, Tousoulis D Tags: Curr Med Chem Source Type: research

Non-vitamin K oral anticoagulant drugs for stroke prevention in patients with atrial fibrillation and chronic kidney disease.
Abstract Atrial fibrillation (AF) and chronic kidney disease (CKD) are disorders with increasing prevalence. The presence of CKD increases the risk of incident AF and vice versa, and the presence of AF may accelerate CKD progression. Nearly a third of patients with established CKD also have AF, whilst half of AF patients may have some degree of renal dysfunction. Both AF and CKD are associated with increased cardiovascular morbidity and mortality, including significantly increased risk of stroke or systemic embolism. Oral anticoagulant therapy (OAC), either with vitamin K antagonists or with non-vitamin K oral ant...
Source: Current Medicinal Chemistry - February 10, 2016 Category: Chemistry Authors: Potpara TS, Jokic V, Dagres N, Larsen TB, Lane DA, Hindricks G, Lip GY Tags: Curr Med Chem Source Type: research