• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Effects of nitro-butoxyl- and butyl-esters of non-steroidal anti-inflammatory drugs compared with parent compounds on the contractility of digital arterial smooth muscle from the fallow deer (Dama dama)
ConclusionsR-( −)-ibuprofen and R-(−)-flurbiprofen, along with the nitro-butoxyl esters of the NSAIDs examined, produce relaxation of segments of deer digital artery smooth muscle in vitro. The evidence presented suggests that their mechanism involves the release of NO or its products.
Source: Inflammopharmacology - September 16, 2021 Category: Drugs & Pharmacology Source Type: research

Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen
ConclusionsFor paracetamol versus ibuprofen, when using LSPS methods in the CPRD, it is only possible to distinguish true effects if those effects are large (hazard ratio  >  2). Due to their smaller hazard ratios, the outcomes under study cannot be differentiated from null effects (represented by negative controls) even if there were a true effect. Based on these data, we conclude that we are unable to determine whether paracetamol is associated with an increased ris k of myocardial infarction, stroke, GI bleeding, and acute renal failure compared to ibuprofen, due to residual confounding.
Source: Drug Safety - June 3, 2020 Category: Drugs & Pharmacology Source Type: research

Channeling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications
ConclusionsAlthough usingselected covariates for propensity score adjustment may not sufficiently reduce bias, large-scale propensity score matching offers a novel approach to consider to mitigate the effects of channeling bias.
Source: Drug Safety - August 5, 2017 Category: Drugs & Pharmacology Source Type: research

Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events: A Systematic Pharmacoepidemiological Review.
CONCLUSION: Further research is needed in order to devise new guidelines for safer use of NSAIDs. PMID: 27468710 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - July 26, 2016 Category: Drugs & Pharmacology Authors: Kontogiorgis C, Valikeserlis I, Hadjipavlou-Litina D, Nena E, Constantinidis TC Tags: Curr Vasc Pharmacol Source Type: research