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Clot lysis time predicts stroke during anticoagulant therapy in patients with atrial fibrillation
ConclusionsImpaired fibrinolysis may predict thromboembolic events in AF patients receiving VKA.
Source: Canadian Journal of Cardiology - August 8, 2019 Category: Cardiology Source Type: research

Anticoagulation in Patients with Advanced Chronic Kidney Disease: Walking the Fine Line between Benefit and Harm
Publication date: Available online 11 July 2019Source: Canadian Journal of CardiologyAuthor(s): Januvi Jegatheswaran, Gregory L. Hundemer, David Massicotte-Azarniouch, Manish M. SoodAbstractChronic kidney disease affects over 3 million Canadians and is highly associated with cardiovascular diseases that require anticoagulation, such as atrial fibrillation and venous thromboembolism. Patients with chronic kidney disease are at a problematic crossroads; they are at high risk of both thrombotic conditions requiring anticoagulation and bleeding complications due to anticoagulation. The limited high-quality clinical evidence to...
Source: Canadian Journal of Cardiology - July 12, 2019 Category: Cardiology Source Type: research

Stroke Prevention, Evaluation of Bleeding Risk, and Anticoagulant Treatment Management in Atrial Fibrillation Contemporary International Guidelines
Publication date: May 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 5Author(s): Marco Proietti, Deirdre A. Lane, Giuseppe Boriani, Gregory Y.H. LipAbstractIn recent years the management of atrial fibrillation patients has progressively and substantially changed because of the introduction of new treatments and the availability of new data regarding the epidemiology and clinical management of these patients. In the past 2 years alone, there have been 7 new guidelines or guideline updates that have been published, which have introduced new recommendations and significantly revised previously published ones. Tw...
Source: Canadian Journal of Cardiology - April 27, 2019 Category: Cardiology Source Type: research

Uninterrupted New Oral Anticoagulants Compared With Uninterrupted Vitamin K Antagonists in Ablation of Atrial Fibrillation: A Meta-analysis
Conclusions Use of uninterrupted NOACs in ablation appears to be as safe and efficacious as use of uninterrupted VKAs.
Source: Canadian Journal of Cardiology - May 24, 2016 Category: Cardiology Source Type: research

Uninterrupted new oral anticoagulants compared to uninterrupted Vitamin K antagonists in ablation of atrial fibrillation. A Meta-analysis
Conclusion Use of uninterrupted NOAC in ablation appears to be as safe and efficacious as uninterrupted VKA. Teaser This meta-analysis compares uninterrupted non vitamin K antagonists (NOAC) with uninterrupted vitamin K antagonists (VKA) in ablation of atrial fibrillation. A total of 3544 patients undergoing ablation with uninterrupted anticoagulation. Overall incidence of stroke/TIA was very low 0.16%, major bleeding was 0.5% and only once case of death reported in the uninterrupted VKA arm. Uninterrupted NOAC appears as safe as uninterrupted VKA with no difference in stroke/TIA, major bleeding, minor bleeding or cardiac tamponade.
Source: Canadian Journal of Cardiology - September 26, 2015 Category: Cardiology Source Type: research