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Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa. 2022 Oct 6. doi: 10.1024/0301-1526/a001031. Online ahead of print.ABSTRACT Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes. It is involved in a repertoire of bi...
Source: Atherosclerosis - October 6, 2022 Category: Cardiology Authors: Marianna Danielli Roisin Clare Thomas Lauren Marie Quinn Bee Kang Tan Source Type: research

Serum cholesterol loading capacity on macrophages is linked to coronary atherosclerosis and cardiovascular event risk in rheumatoid arthritis
CONCLUSION: CLC was linked to long-term cardiovascular event risk in RA and associated with high-risk low attenuation and obstructive coronary plaque presence and burden in bDMARD non-users. Its prospective validation as a predictive biomarker may be, therefore, warranted.PMID:36113961 | DOI:10.1136/rmdopen-2022-002411
Source: Atherosclerosis - September 16, 2022 Category: Cardiology Authors: George Athanasios Karpouzas Bianca Papotti Sarah Ormseth Marcella Palumbo Elizabeth Hernandez Maria Pia Adorni Francesca Zimetti Matthew Budoff Nicoletta Ronda Source Type: research

Psoriasis a Cause of Cardiovascular Diseases: A Review Article
Cureus. 2022 Aug 8;14(8):e27767. doi: 10.7759/cureus.27767. eCollection 2022 Aug.ABSTRACTPsoriasis is a severe, chronic inflammatory disease characterized by erythematous plaques across the extensor surfaces of the skin. Psoriasis has been linked to a higher threat of vascular events like myocardial infarction and stroke. Other associated cardiovascular disorders in the case of psoriasis include building up atherosclerosis, non-ischemic dilated cardiomyopathy, and psoriatic arthritis. Individuals can use International Classification of Diseases (ICD-9) codes to identify cardiovascular disease/comorbidities and related risk...
Source: Atherosclerosis - September 15, 2022 Category: Cardiology Authors: Aditi Gupta Bhushan Madke Source Type: research

Management of Cardiovascular Disease Risk in Rheumatoid Arthritis
J Clin Med. 2022 Jun 17;11(12):3487. doi: 10.3390/jcm11123487.ABSTRACTCardiovascular diseases, including ischemic heart disease and stroke, reportedly comprise the top two causes of global mortality [...].PMID:35743556 | DOI:10.3390/jcm11123487
Source: Atherosclerosis - June 24, 2022 Category: Cardiology Authors: Patrick H Dessein Miguel A Gonzalez-Gay Source Type: research

Giant cell arteritis-related stroke in a large inception cohort: A comparative study
CONCLUSIONS: The location of stroke and assessment of ECU results and CRP level could help improve the prognosis of GCA-related stroke by bringing this condition to the clinician's attention more quickly, thus shortening diagnostic delay.PMID:35512621 | DOI:10.1016/j.semarthrit.2022.152020
Source: Atherosclerosis - May 5, 2022 Category: Cardiology Authors: Simon Parreau St éphanie Dumonteil Francisco Macian Montoro Guillaume Gondran Holy Bezanahary Sylvain Palat Kim-Heang Ly Anne-Laure Fauchais Eric Liozon Source Type: research

Oral tolerance: an updated review
Immunol Lett. 2022 Apr 5:S0165-2478(22)00041-4. doi: 10.1016/j.imlet.2022.03.007. Online ahead of print.ABSTRACTOral tolerance (OT) has classically been defined as the specific suppression of cellular and/or humoral immune responses to an antigen by prior administration of the antigen through the oral route. Multiple mechanisms have been proposed to explain the induction of OT including T cell clonal depletion and anergy when high doses of antigens are fed, and regulatory T (Treg) cell generation following oral administration of low and repeated doses of antigens. Oral antigen administration suppresses the immune response ...
Source: Atherosclerosis - April 8, 2022 Category: Cardiology Authors: Rafael M Rezende Howard L Weiner Source Type: research

Internal carotid artery occlusion related to poorly controlled rheumatoid arthritis presenting with continuous hand shaking: A case report and literature review
Medicine (Baltimore). 2022 Mar 4;101(9):e29001. doi: 10.1097/MD.0000000000029001.ABSTRACTRATIONALE: Limb-shaking syndrome is a special manifestation of transient ischemic attack, resulting from internal carotid artery (ICA) occlusion. Extra-articular manifestations of rheumatoid arthritis (RA) are likely to occur in patients with severe or active RA. RA may accelerate atherosclerotic processes through inflammation. Here, we present a case of ICA occlusion related to poorly controlled RA that presented with continuous hand shaking.PATIENT CONCERNS: A 73-year-old man with a history of poorly controlled RA developed total occ...
Source: Atherosclerosis - March 4, 2022 Category: Cardiology Authors: Ching-Fang Chien Chun-Yi Tsai Meng-Ni Wu Chiou-Lian Lai Li-Min Liou Source Type: research

Updates in the Impact of Chronic Systemic Inflammation on Vascular Inflammation by Positron Emission Tomography (PET)
Curr Cardiol Rep. 2022 Feb 16. doi: 10.1007/s11886-022-01651-2. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: In this review, we focus on the clinical and epidemiological studies pertaining to systemic and vascular inflammation by positron emission tomography (PET) in patients with chronic inflammatory conditions such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), and psoriasis to highlight the importance of chronic systemic inflammation on vascular inflammation by PET in these disease states.RECENT FINDINGS: Recent clinical and translation advancements have demonst...
Source: Atherosclerosis - February 16, 2022 Category: Cardiology Authors: Philip M Parel Alexander R Berg Christin G Hong Elizabeth M Florida Ross O'Hagan Alexander V Sorokin Nehal N Mehta Source Type: research

A journey through clinic and research
I started to study Medicine at the University of Genoa, Italy more than 20 years ago and I now realize that I was quite far from understanding what ‘Medicine’ really means. After weeks and weeks spent on books during the first year, I understood that becoming a MD not only requires the willingness to help people with health problems, but also strong motivation and dedication to learn a huge amount of notions. In Italy, as it is the case for several other countries, the University courses last 6 years, during which the MD student is fully engaged by individual study, lessons and seminars, exercises, and internships. Wit...
Source: European Heart Journal - March 29, 2021 Category: Cardiology Source Type: research

Hypertension and comorbidities in rural and urban Chinese older people: an epidemiological sub-analysis from the SAGE study.
CONCLUSIONS: Our study implies that health promotion policies targeting older people should be developed. Rural areas should be a priority, and investment in the quality of healthcare in rural areas is urgently needed. PMID: 32886761 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - September 3, 2020 Category: Cardiology Authors: Li H, Hu YJ, Lin H, Xia H, Guo Y, Wu F Tags: Am J Hypertens Source Type: research

TNF α and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis.
TNFα and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis. Am J Hypertens. 2020 Jun 05;: Authors: Lamb FS, Choi H, Miller MR, Stark RJ Abstract Hypertension and atherosclerosis, the predecessors of stroke and myocardial infarction, are chronic vascular inflammatory reactions. Tumor necrosis factor alpha (TNFα), the "master" pro-inflammatory cytokine, contributes to both the initiation and maintenance of vascular inflammation. TNFα induces reactive oxygen species (ROS) production which drives the redox reactions that constitute "ROS signaling". However, t...
Source: American Journal of Hypertension - June 4, 2020 Category: Cardiology Authors: Lamb FS, Choi H, Miller MR, Stark RJ Tags: Am J Hypertens Source Type: research

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